NFATC2

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.{{cite web | title = Entrez Gene: NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4773}}

Translocation forming an in frame fusions product between EWSR1 gene and the NFATc2 gene has been described in bone tumor with a Ewing sarcoma-like clinical appearance. The translocation breakpoint led to the loss of the controlling elements of the NFATc2 protein and the fusion of the N terminal region of the EWSR1 gene conferred constant activation of the protein.{{cite journal | vauthors = Szuhai K, Ijszenga M, de Jong D, Karseladze A, Tanke HJ, Hogendoorn PC | title = The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology | journal = Clinical Cancer Research | volume = 15 | issue = 7 | pages = 2259–68 | date = Apr 2009 | pmid = 19318479 | doi = 10.1158/1078-0432.CCR-08-2184 | doi-access = free }}

NFATC2 has been shown to interact with MEF2D,{{cite journal | vauthors = Youn HD, Chatila TA, Liu JO | title = Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis | journal = The EMBO Journal | volume = 19 | issue = 16 | pages = 4323–31 | date = Aug 2000 | pmid = 10944115 | pmc = 302027 | doi = 10.1093/emboj/19.16.4323 }} EP300,{{cite journal | vauthors = García-Rodríguez C, Rao A | title = Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP) | journal = The Journal of Experimental Medicine | volume = 187 | issue = 12 | pages = 2031–6 | date = Jun 1998 | pmid = 9625762 | pmc = 2212364 | doi = 10.1084/jem.187.12.2031 }} IRF4{{cite journal | vauthors = Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H, Glimcher LH | title = Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression | journal = The Journal of Experimental Medicine | volume = 195 | issue = 8 | pages = 1003–12 | date = Apr 2002 | pmid = 11956291 | pmc = 2193700 | doi = 10.1084/jem.20011128 }} and Protein kinase Mζ.{{cite journal | vauthors = San-Antonio B, Iñiguez MA, Fresno M | title = Protein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activity | journal = The Journal of Biological Chemistry | volume = 277 | issue = 30 | pages = 27073–80 | date = Jul 2002 | pmid = 12021260 | doi = 10.1074/jbc.M106983200 | doi-access = free }} Prostaglandin F2alpha stimulates a NFCT2 pathway stimulating growth of skeletal muscle cells.{{cite journal| author=Horsley V, Pavlath GK| title=Prostaglandin F2(alpha) stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway. | journal=J Cell Biol | year= 2003 | volume= 161 | issue= 1 | pages= 111–8 | pmid=12695501 | doi=10.1083/jcb.200208085 | pmc=2172881 }}

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• {{cite journal | vauthors = Rao A, Luo C, Hogan PG | title = Transcription factors of the NFAT family: regulation and function | journal = Annual Review of Immunology | volume = 15 | pages = 707–747 | year = 1997 | pmid = 9143705 | doi = 10.1146/annurev.immunol.15.1.707 }}
• {{cite journal | vauthors = Crabtree GR | title = Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT | journal = Cell | volume = 96 | issue = 5 | pages = 611–614 | date = Mar 1999 | pmid = 10089876 | doi = 10.1016/S0092-8674(00)80571-1 | s2cid = 8817053 | doi-access = free }}
• {{cite journal | vauthors = Horsley V, Pavlath GK | title = NFAT: ubiquitous regulator of cell differentiation and adaptation | journal = The Journal of Cell Biology | volume = 156 | issue = 5 | pages = 771–774 | date = Mar 2002 | pmid = 11877454 | pmc = 2173310 | doi = 10.1083/jcb.200111073 }}
• {{cite journal | vauthors = Aramburu J, Azzoni L, Rao A, Perussia B | title = Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding | journal = The Journal of Experimental Medicine | volume = 182 | issue = 3 | pages = 801–810 | date = Sep 1995 | pmid = 7650486 | pmc = 2192167 | doi = 10.1084/jem.182.3.801 }}
• {{cite journal | vauthors = Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD, Duprat S, Houlgatte R, Jumeau MN, Lamy B | title = [IMAGE: molecular integration of the analysis of the human genome and its expression] | journal = Comptes Rendus de l'Académie des Sciences, Série III | volume = 318 | issue = 2 | pages = 263–72 | date = Feb 1995 | pmid = 7757816 }}
• {{cite journal | vauthors = Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree GR, Francke U | title = Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp | journal = Cytogenetics and Cell Genetics | volume = 68 | issue = 3–4 | pages = 185–191 | year = 1995 | pmid = 7842733 | doi = 10.1159/000133910 }}
• {{cite book | vauthors = Ho S, Timmerman L, Northrop J, Crabtree GR | title = Mechanisms of Lymphocyte Activation and Immune Regulation V | chapter = Cloning and Characterization of NF-ATc and NF-ATp: The Cytoplasmic Components of NF-AT | series = Advances in Experimental Medicine and Biology | date = 1994 | volume = 365 | pages = 167–73 | pmid = 7887301 | doi = 10.1007/978-1-4899-0987-9_17 | isbn = 978-1-4899-0989-3 }}
• {{cite journal | vauthors = Jabado N, Le Deist F, Fisher A, Hivroz C | title = Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity | journal = European Journal of Immunology | volume = 24 | issue = 11 | pages = 2646–2652 | date = Nov 1994 | pmid = 7957556 | doi = 10.1002/eji.1830241112 | s2cid = 30435577 }}
• {{cite journal | vauthors = Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A | title = Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif | journal = Biochemical and Biophysical Research Communications | volume = 205 | issue = 1 | pages = 467–474 | date = Nov 1994 | pmid = 7999066 | doi = 10.1006/bbrc.1994.2689 }}
• {{cite journal | vauthors = Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, Curran T, Rao A | title = The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun | journal = Nature | volume = 365 | issue = 6444 | pages = 352–355 | date = Sep 1993 | pmid = 8397339 | doi = 10.1038/365352a0 | bibcode = 1993Natur.365..352J | s2cid = 4283223 }}
• {{cite journal | vauthors = Luo C, Burgeon E, Carew JA, McCaffrey PG, Badalian TM, Lane WS, Hogan PG, Rao A | title = Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes | journal = Molecular and Cellular Biology | volume = 16 | issue = 7 | pages = 3955–66 | date = Jul 1996 | pmid = 8668213 | pmc = 231392 | doi = 10.1128/mcb.16.7.3955}}
• {{cite journal | vauthors = Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT | title = Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering | journal = European Journal of Immunology | volume = 26 | issue = 9 | pages = 2181–2188 | date = Sep 1996 | pmid = 8814265 | doi = 10.1002/eji.1830260933 | s2cid = 23430217 }}
• {{cite journal | vauthors = Copeland KF, McKay PJ, Rosenthal KL | title = Suppression of the human immunodeficiency virus long terminal repeat by CD8+ T cells is dependent on the NFAT-1 element | journal = AIDS Research and Human Retroviruses | volume = 12 | issue = 2 | pages = 143–148 | date = Jan 1996 | pmid = 8834464 | doi = 10.1089/aid.1996.12.143 }}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
• {{cite journal | vauthors = Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH | title = NF-AT-Driven interleukin-4 transcription potentiated by NIP45 | journal = Science | volume = 274 | issue = 5294 | pages = 1903–1905 | date = Dec 1996 | pmid = 8943202 | doi = 10.1126/science.274.5294.1903 | bibcode = 1996Sci...274.1903H | s2cid = 29436825 }}
• {{cite journal | vauthors = Lyakh L, Ghosh P, Rice NR | title = Expression of NFAT-family proteins in normal human T cells | journal = Molecular and Cellular Biology | volume = 17 | issue = 5 | pages = 2475–84 | date = May 1997 | pmid = 9111316 | pmc = 232096 | doi = 10.1128/mcb.17.5.2475}}
• {{cite journal | vauthors = Amasaki Y, Masuda ES, Imamura R, Arai K, Arai N | title = Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets | journal = Journal of Immunology | volume = 160 | issue = 5 | pages = 2324–33 | date = Mar 1998 | doi = 10.4049/jimmunol.160.5.2324 | pmid = 9498773 | s2cid = 19932048 | doi-access = free }}
• {{cite journal | vauthors = Chen L, Glover JN, Hogan PG, Rao A, Harrison SC | title = Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA | journal = Nature | volume = 392 | issue = 6671 | pages = 42–48 | date = Mar 1998 | pmid = 9510247 | doi = 10.1038/32100 | bibcode = 1998Natur.392...42C | s2cid = 4305535 }}

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• {{MeshName|NFATC2+protein,+human}}

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{{Transcription factors|g4}}

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Category:Transcription factors

Category:Human proteins