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NKX2-2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.{{cite journal | vauthors = Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI | title = Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese | journal = Diabetes | volume = 47 | issue = 8 | pages = 1356–1358 | date = Aug 1998 | pmid = 9703340 | doi = 10.2337/diabetes.47.8.1356 }}{{cite journal | vauthors = Price M, Lazzaro D, Pohl T, Mattei MG, Rüther U, Olivo JC, Duboule D, Di Lauro R | title = Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain | journal = Neuron | volume = 8 | issue = 2 | pages = 241–255 | date = Feb 1992 | pmid = 1346742 | doi = 10.1016/0896-6273(92)90291-K | s2cid = 22766848 }}{{cite web | title = Entrez Gene: NKX2-2 NK2 transcription factor related, locus 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4821}}

Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as.{{cite journal | vauthors = Tochitani S, Hayashizaki Y | title = Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation | journal = Biochemical and Biophysical Research Communications | volume = 372 | issue = 4 | pages = 691–696 | date = Aug 2008 | pmid = 18538132 | doi = 10.1016/j.bbrc.2008.05.127 }}

In the developing spinal cord, Nkx-2.2 regulates IRX3 thereby contributing to the proper differentiation of the ventral horn neurons.{{cite journal | vauthors = Lovrics A, Gao Y, Juhász B, Bock I, Byrne HM, Dinnyés A, Kovács KA | title = Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord | journal = PLOS ONE | volume = 9 | issue = 11 | pages = e111430 | date = November 2014 | pmid = 25398016 | doi = 10.1371/journal.pone.0111430 | pmc=4232242| bibcode = 2014PLoSO...9k1430L | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Hessabi B, Schmidt I, Walther R | title = The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals | journal = Biochemical and Biophysical Research Communications | volume = 270 | issue = 3 | pages = 695–700 | date = Apr 2000 | pmid = 10772886 | doi = 10.1006/bbrc.2000.2491 }}
  • {{cite journal | vauthors = Wang CC, Brodnicki T, Copeland NG, Jenkins NA, Harvey RP | title = Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals | journal = Mammalian Genome | volume = 11 | issue = 6 | pages = 466–468 | date = Jun 2000 | pmid = 10818213 | doi = 10.1007/s003350010089 | s2cid = 29283599 }}
  • {{cite journal | vauthors = Sun T, Dong H, Wu L, Kane M, Rowitch DH, Stiles CD | title = Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex | journal = The Journal of Neuroscience | volume = 23 | issue = 29 | pages = 9547–9556 | date = Oct 2003 | pmid = 14573534 | doi = 10.1523/JNEUROSCI.23-29-09547.2003| pmc = 6740479 | doi-access = free }}
  • {{cite journal | vauthors = Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, Lessnick SL | title = Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma | journal = Cancer Cell | volume = 9 | issue = 5 | pages = 405–416 | date = May 2006 | pmid = 16697960 | doi = 10.1016/j.ccr.2006.04.004 | doi-access = free }}
  • {{cite journal | vauthors = Pauls S, Zecchin E, Tiso N, Bortolussi M, Argenton F | title = Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts | journal = Developmental Biology | volume = 304 | issue = 2 | pages = 875–890 | date = Apr 2007 | pmid = 17335795 | doi = 10.1016/j.ydbio.2007.01.024 | doi-access = free }}

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{{Transcription factors|g3}}

Category:Transcription factors

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