Nafadotride

{{Short description|Nervous system drug}}

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| Verifiedfields = changed

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| verifiedrevid = 401341708

| ImageFile=Nafadotride.svg

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| IUPACName=N-{[(2S)-1-butylpyrrolidin-2-yl]methyl}-4-cyano-1-methoxy-2-naphthamide

| OtherNames=

|Section1={{Chembox Identifiers

| CASNo_Ref = {{cascite|correct|CAS}}

| CASNo=149649-22-9

| ChEBI = 64191

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 286252

| ChemSpiderID = 2652798

| IUPHAR_ligand = 44

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = JP25MZ26IQ

| PubChem=3408722

| StdInChI=1S/C22H27N3O2/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26)

| StdInChIKey = IDZASIQMRGPBCQ-UHFFFAOYSA-N

| SMILES=CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC

| MeSHName=Nafadotride

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|Section2={{Chembox Properties

| C=22 | H=27 | N=3 | O=2

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|Section3={{Chembox Hazards

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Nafadotride is a dopamine antagonist with some selectivity for the D₃ subtype (9.6-fold preference for D₃ over D₂).Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 agonist. Nature. 1999;400:371–375.