Nicholas Lowe

Lowe graduated from University of Liverpool School of Medicine,{{cite web |title= Nicholas Charles LOWE |url=https://www.gmc-uk.org/doctors/2616292 |website=General Medical Council}} England, in 1968. In 1975, he was awarded a Research Fellowship at the Scripps Research Institute where he worked with Professor Richard Stoughton, in skin pharmacology and percutaneous absorption. His doctoral MD research thesis described mechanisms and control of excessive epidermal cell growth.

In 1975, as a professor of dermatology at University of Wisconsin, he performed research on how ultraviolet light damages the skin and contributes to skin cancers.{{cite journal|last1=Lowe|first1=NJ|last2=Stoughton|first2=RB|title=Essential fatty acid deficient hairless mouse: a model of chronic epidermal hyperproliferation.|journal=The British Journal of Dermatology|date=February 1977|volume=96|issue=2|pages=155–62|doi=10.1111/j.1365-2133.1977.tb12537.x|pmid=843450|s2cid=2486355}} He was subsequently appointed to Professor of Dermatology{{cite web |title=Spotlight on: Nicholas Lowe, MB, ChB, MD, FRCP |url=https://www.hmpgloballearningnetwork.com/site/thederm/site/cathlab/event/spotlight-nicholas-lowe-mb-chb-md-frcp-facp |website=The Dermatologist |publisher=Dermatology Learning Network}} at David Geffen School of Medicine at UCLA, Los Angeles, California, United States.

In 1980, he founded the largest psoriasis therapy centre in Southern California, the Dermatology Institute and Skin Care Center,{{cite web|title=Clinical Science Institute - Dermatology Institute & Skin Care Center|url=https://www.discc.com/clinical-science-institute/|website=www.discc.com|accessdate=21 January 2018}} where he also conducted some of the first research studies on vitamin A derivatives for psoriasis, acne and other disfiguring skin diseases. He was appointed to the Medical Advisory Board of the National Psoriasis Foundation in the US.{{citation needed|date=January 2023}}

In the 1980s, he conducted one of the first clinical research studies in psoriasis a completely new category of drugs for the treatment of psoriasis known as biologic drugs. These were drugs that were capable of targeting immunologic defects in psoriasis; new generations of these biological drugs are now used worldwide as biologic therapy for psoriasis, arthritis and related diseases.{{cite journal|last1=Lowe|first1=N J|title=Phototherapy and dithranol treatment of psoriasis.|journal=BMJ|date=28 March 1987|volume=294|issue=6575|pages=839|doi=10.1136/bmj.294.6575.839|pmid=3105768|pmc=1245892}}

In 1980, he performed research on a category of the first new sunscreens that protected from long wave ultraviolet (or UVA) and UVB. He also confirmed that UVA was responsible for skin aging, skin cancer, unwanted pigmentation and skin sagging and during this research period he also proved the protectiveness of sunscreens against UVA damage in human studies.Sunscreens: Development, Evaluation, and Regulatory Aspects. [https://books.google.com/books?id=cCBtAAAAMAAJ "M Decker"], Google Books.Physician's Guide to Sunscreens. [https://books.google.com/books?id=frKd3A7qVCoC "Dekker"], Google Books.

In the 1990s, he published research on the use of ultra-pulsed carbon dioxide lasers in dermatology,{{cite journal|last1=LOWE|first1=NICHOLAS J.|last2=LASK|first2=GARY|last3=GRIFFIN|first3=MOLLY E.|last4=MAXWELL|first4=ANNE|last5=LOWE|first5=PHILIPPA|last6=QUILADA|first6=FLORIZZA|title=Skin Resurfacing with the Ultrapulse Carbon Dioxide Laser|journal=Dermatologic Surgery|date=December 1995|volume=21|issue=12|pages=1025–1029|doi=10.1111/j.1524-4725.1995.tb00552.x|pmid=7496669|s2cid=23913846}} which were developed and used to reduce skin aging, skin sagging, wrinkling and improve disfiguring scars.{{cite journal|last1=LOWE|first1=NICHOLAS J.|last2=LASK|first2=GARY|last3=GRIFFIN|first3=MOLLY E.|title=Laser Skin Resurfacing|journal=Dermatologic Surgery|date=December 1995|volume=21|issue=12|pages=1017–1019|doi=10.1111/j.1524-4725.1995.tb00550.x|s2cid=30122352}}

Lowe was the lead investigator in the first placebo control study of Botox for reducing forehead frown lines. At this time neither the dose nor was the safety of Botox was known. Lowe described the how to measure the improvement and using muscle recording electrodes and found the correct muscles to inject Botox. Together with dermatologist Dr Alastair Carruthers, he presented their early studies on the aesthetic use of Botox at the American Academy of Dermatology symposium.{{cite web|title=In 1996 at the annual meeting of The American Academy of Dermatology in Washington, a presentation by dermatologist Dr. Nicholas Lowe showed that BOTOX® was useful for improving facial expression lines.|url=https://www.dermatlanta.com/cosmetic-dermatology/botox-cosmetic-dysport/|website=Dermatology Associates of Atlanta|date=4 June 2013 |accessdate=8 July 2015}} He has also shown that Botox injections are an effective way of reducing and controlling the sweating for long periods of time. Pivotal publications on this include a British Medical Journal paper.{{cite journal|last1=Naumann|first1=M|last2=Lowe|first2=N J|title=Botulinum toxin type A in treatment of bilateral primary axillary hyperhidrosis: randomised, parallel group, double blind, placebo controlled|journal=BMJ|date=15 September 2001|volume=323|issue=7313|pages=596–599|doi=10.1136/bmj.323.7313.596|pmid=11557704|pmc=55572}}

• 1979 and 1984 American Academy of Dermatology Gold Award for Scientific Exhibits
• 1988 Elected to American Dermatological Association{{cite web |title=Dr Nicholas James LOWE |url=https://www.imcas.com/en/profile/dr-nicholas-james-lowe |website=IMCAS}}
• 1990 President, Pacific Dermatologic Association{{cite web |title=Dr Nicholas James LOWE|url=https://www.imcas.com/en/profile/dr-nicholas-james-lowe |website=IMCAS}}
• 1999 Clinical Professor “Emeritus” for ten years’ service to the Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA{{cite web |title=Meet Dr Nicck Lowe |url=https://aestheticsinsider.co.uk/meet-our-experts/dr-nick-lowe/ |website=Aesthetics Insider}}
• 2005 Commemorative of 25th year of membership of the American Academy of Dermatology

Dr Lowe has written over 450 clinical and research papers and 19 books, sits on the editorial board of scientific journals and is a founding editor of the Journal of Cutaneous Laser Therapy.{{cite journal|last1=P Lask, Nicholas J Lowe|first1=Gary|title=Editorial|journal=Journal of Cosmetic and Laser Therapy|date=January 1999|volume=1|issue=1|pages=1–2|doi=10.1080/14628839950517020}}{{cite web |last1=Lowe |first1=Nicholas |title=Lowe |url=https://www.researchgate.net/profile/Nicholas-Lowe-2 |website=Research Gate}}

Books for the general public:

• 1993 Managing Your Psoriasis{{cite book|last1=Lowe|first1=Nicholas J.|title=Managing your psoriasis|date=1993|publisher=MasterMedia|location=New York|isbn=978-0942361841}}
• 1999 Skin Secrets: The Medical Facts Versus The Beauty Fiction{{cite book|last1=Sellar|first1=Nicholas Lowe, Polly|title=Skin secrets : the medical facts versus the beauty fiction|date=1999|publisher=Collins & Brown|location=London|isbn=1855856654}}
• 2005 Away with Wrinkles: A Top Dermatologist's Secrets for a Younger Face{{cite book|last1=Lowe|first1=Nick|title=Away with wrinkles : the essential guide to a younger-looking face|date=2005|publisher=Marlowe & Co.|location=New York|isbn=1569244588}}
• 2007 The Wrinkle Revolution: Everywoman's Guide to a Younger Looking Skin{{cite book|last1=Lowe|first1=Nick|title=The wrinkle revolution : a top dermatologist's latest secrets|date=2007|publisher=Kyle Cathie Ltd|location=London|isbn=978-1856267717|edition= Rev..}}
• 2016 Perfectly Clear, The Perfect Guide to Clear Skin{{cite book|last1=Lowe|first1=Nick|title=Perfectly Clear|date=10 March 2016 |publisher=Troubador Publishing|isbn=978-1785890833}}

Published medical books in chronological order are:

• 1984-89 Models in Dermatology, Vol. I-IV Karger Publications{{cite book |title=Models in Dermatology, Vol. 1 |publisher=Karger |isbn=978-3-8055-3945-6 |url=https://www.karger.com/Book/Home/220680}}{{cite book |title=Models in Dermatology, Vol. 2 |publisher=Karger |isbn=978-3-8055-3947-0 |url=https://www.karger.com/Book/Home/220682}}{{cite book |title=Models in Dermatology, Vol. 3 |date=1987 |publisher=Karger |isbn=978-3-8055-4239-5 |url=https://www.karger.com/Book/Home/220968}}{{cite book |title=Models in Dermatology, Vol. 4 |year=1985 |publisher=Karger |isbn=978-3-8055-4761-1 |url=https://www.karger.com/Book/Home/221490}}
• 1989 Nonsteroidal Anti-inflammatory Agents, by Karger PublicationsNonsteroidal anti-inflammatory drugs. [https://books.google.com/books?id=ItxsAAAAMAAJ "Karger"], Google Books.
• 1990 Sunscreens: Development, Evaluation and Usage, Marcel Dekker;Sunscreens: Development, Evaluation, and Regulatory Aspects. [https://books.google.com/books?id=cCBtAAAAMAAJ "M Decker"], Google Books. 2nd ed. 1996
• 1991 Sunscreens: A Physicians Guide. Marcel DekkerPhysician's Guide to Sunscreens. [https://books.google.com/books?id=frKd3A7qVCoC "Dekker"], Google Books.
• 1992 Practical Psoriasis Therapy, 2nd Edition, Mosby YearBook, New York.{{cite book|last1=Lowe|first1=Nicholas J. Lowe|title=Practical psoriasis therapy|date=1993|publisher=Mosby-Year Book|location=St. Louis|isbn=9780801671814|edition= 2nd.}}
• 1993 Managing Your Psoriasis, Master Media, New YorkManaging Your Psoriasis. [https://books.google.com/books?id=miFvqjibR9oC "Master Media"], Google Books.
• 1995 Retinoids for the Clinician, Martin Dunitz, London;2nd ed., 1997Psoriasis: Retinoids, Second Edition. [https://books.google.com/books?id=GR_qIp_jKn4C "Taylor & Francis"], Google Books.
• 2000 Lasers in Cutaneous and Costmetic Surgery, Churchill Livingstone, NY, London.{{cite book|last1=Lowe|first1=Gary P. Lask; Nicholas J.|title=Lasers in cutaneous and cosmetic surgery|date=2000|publisher=Churchill Livingstone|location=Philadelphia [u.a.]|isbn=9780443076398|edition= 1st}}
• 2001 Facial Rejuvenation: Combination Minimally Invasive Treatments, Martin Dunitz, London{{cite book|last1=al.]|first1=Nicholas J. Lowe ... [et|title=Textbook of facial rejuvenation : the minimally invasive combination approach|date=2001|publisher=Martin Dunitz|location=London|isbn=9781841840956|edition= Repr.}}
• 2003 Botox: Aesthetic ConditionsBotox: Aesthetic Conditions. [https://books.google.com/books?id=BoWDkgEACAAJ "Taylor & Francis"], Google Books.
• 2003 Psoriasis - A Patient Guide, Martin Dunitz, London 3rd edition. Highly commended, BMA Medical Book Competition 2004Psoriasis: A Patient's Guide, Third Edition. [https://books.google.com/books?id=rUNQ0-9L7uMC "Taylor & Francis"], Google Books.

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Category:1944 births

Category:Living people

Category:British dermatologists

Category:University of California, Los Angeles faculty

Category:Alumni of the University of Liverpool

Category:University of Wisconsin–Madison faculty

Category:Fellows of the Royal College of Physicians