Nicola Pohl

{{short description|American chemist}}

{{Infobox scientist

| name = Nicola Lucia B. Pohl

| workplaces = Iowa State University
Indiana University Bloomington
Stanford University

| alma_mater = University of Wisconsin–Madison (PhD)
Radcliffe College (MA)

| thesis_title = Synthesis of carbohydrate-based ligands for the selectins and galectins

| thesis_url = http://www.worldcat.org/oclc/39496143

| thesis_year = 1997

| doctoral_advisor = Laura L. Kiessling

}}

Nicola Lucia B. Pohl is an American chemist who is the Joan & Marvin Carmack Chair at Indiana University Bloomington. She also serves as Associate Dean of Natural and Mathematical Sciences. Her research considers new approaches to make and analyse sugars. In 2020 she was elected a Fellow of the American Association for the Advancement of Science.

Early life and education

Pohl earned her master's degree in at Radcliffe College. She graduated in 1991 having majored in English and American literature. Her graduate dissertation considered the works of Flannery O'Connor and Walker Percy.{{Cite thesis|title=Disease as a metaphor for sin and guilt in the works of Flannery O'Connor and Walker Percy|url=https://www.worldcat.org/oclc/76976445|date=1991|language=English|first=Nicola L|last=Pohl|oclc=76976445 }} After completing her master's, Pohl started a doctoral research programme in chemistry at the University of Wisconsin–Madison. She has said that she was inspired by her Harvard chemistry professor, Dudley R. Herschbach.{{Cite web|title=Inside Iowa State|url=https://archive.inside.iastate.edu/2004/0812/pohl.shtml|access-date=2020-11-26|website=archive.inside.iastate.edu}} Her doctoral research involved the synthesis of carbohydrate-based ligands under the supervision of Laura L. Kiessling. She joined Stanford University as a National Institutes of Health postdoctoral fellow in the research group of Chaitan Khosla.

Research and career

In 2000 Pohl joined the faculty at Iowa State University.{{Cite journal|date=2012-08-20|title=Nicola Pohl|journal=Chemical & Engineering News Archive|volume=90|issue=34|pages=46|doi=10.1021/cen-09034-cover8|issn=0009-2347|doi-access=free|last1=Carmen Drahl }} She spent twelve years in Iowa, eventually being made Wilkinson Professor of Chemistry and Biomedical Engineering.{{Cite web|last=|first=|date=|title=Nicola Pohl, PhD|url=https://www.nanovaccine.iastate.edu/researchers/nicola-pohl-phd/|archive-url=|archive-date=|access-date=2020-11-26|website=www.nanovaccine.iastate.edu}} In 2008 she founded LuCELLa Biosciences, a spin-out company who specialise in the custom synthesis of carbohydrates. Pohl joined Indiana University Bloomington in 2012, where she was made the Professor and Joan & Marvin Carmack Chair.

Pohl is interested in the synthesis and characterisation of sugars in an effort to better understand their role in biological function. By better understanding the interactions of carbohydrates, Pohl believes that she will be able to rationally design vaccinations and other therapies. She demonstrated an oligosaccharide synthesis process that involved automated solution-phase methods. The automation process involves the use of fluorocarbon tags that can be used to pattern the surfaces of tagged molecules to form carbohydrate microarrays. Pohl spent 2019 as a Fulbright Program scholar at the University of Natural Resources and Life Sciences, Vienna.{{Cite web|title=Nicola Pohl {{!}} Fulbright Scholar Program|url=https://www.cies.org/grantee/nicola-pohl|access-date=2020-11-26|website=www.cies.org}}

Awards and honours

  • 2004 National Science Foundation CAREER Award
  • 2010 American Chemical Society Horace S. Isbell Award{{Cite web|title=News Expert Profile|url=https://news.iu.edu/iu-experts/profile/index.html|access-date=2020-11-26|website=News at IU|language=en}}
  • 2017 Elected Edward, Frances, and Shirley B. Daniels Fellow at Harvard University{{Citation|title=Morris, Norma Frances, (born 17 April 1935), Research Fellow, University College London, since 1995|date=2007-12-01|url=http://dx.doi.org/10.1093/ww/9780199540884.013.28189|work=Who's Who|publisher=Oxford University Press|doi=10.1093/ww/9780199540884.013.28189 |access-date=2020-11-26|url-access=subscription}}
  • 2017 International Fluorous Technology Award{{citation needed|date=November 2020}}
  • 2017 Silicon Valley Chemist Harry and Carol Mosher Award{{Cite web|last=|first=|date=2018|title=Bridging the Gap for Biotherapeutics Development: Joining Automated Oligosaccharide to Automated Peptide Synthesis|url=http://www.svacs.org/newsletter/news1803.pdf|archive-url=|archive-date=|access-date=|website=SVACS}}
  • 2018 American Chemical Society Melville L. Wolfram Award{{citation needed|date=November 2020}}
  • 2019 Fulbright Program Scholar
  • 2020 Elected a Fellow of the American Association for the Advancement of Science{{Cite web|title=AAAS Announces Leading Scientists Elected as 2020 Fellows {{!}} American Association for the Advancement of Science|url=https://www.aaas.org/news/aaas-announces-leading-scientists-elected-2020-fellows|access-date=2020-11-26|website=www.aaas.org|language=en}}

Selected publications

  • {{Cite journal|last1=Kiessling|first1=Laura L.|last2=Pohl|first2=Nicola L.|date=1996-02-01|title=Strength in numbers: non-natural polyvalent carbohydrate derivatives|journal=Chemistry & Biology|language=en|volume=3|issue=2|pages=71–77|doi=10.1016/S1074-5521(96)90280-X|pmid=8807830 |issn=1074-5521|doi-access=free}}
  • {{Cite journal|last1=Ko|first1=Kwang-Seuk|last2=Jaipuri|first2=Firoz A.|last3=Pohl|first3=Nicola L.|date=2005-09-28|title=Fluorous-Based Carbohydrate Microarrays|url=https://doi.org/10.1021/ja054811k|journal=Journal of the American Chemical Society|volume=127|issue=38|pages=13162–13163|doi=10.1021/ja054811k|pmid=16173741 |issn=0002-7863|url-access=subscription}}
  • {{Cite journal|last1=Wacker|first1=Michael|last2=Feldman|first2=Mario F.|last3=Callewaert|first3=Nico|last4=Kowarik|first4=Michael|last5=Clarke|first5=Bradley R.|last6=Pohl|first6=Nicola L.|last7=Hernandez|first7=Marcela|last8=Vines|first8=Enrique D.|last9=Valvano|first9=Miguel A.|last10=Whitfield|first10=Chris|last11=Aebi|first11=Markus|date=2006-05-02|title=Substrate specificity of bacterial oligosaccharyltransferase suggests a common transfer mechanism for the bacterial and eukaryotic systems|journal=Proceedings of the National Academy of Sciences|language=en|volume=103|issue=18|pages=7088–7093|pmc=1459022|doi=10.1073/pnas.0509207103|issn=0027-8424|pmid=16641107|doi-access=free}}

References