Once in a Lifetime

• Once in a Lifetime (1932 film), based on the play by Kaufman and Hart, starring Jack Oakie
• Once in a Lifetime, a 1984 TV special by Talking Heads, also known as "Talking Heads vs. Television"
• Once in a Lifetime (1994 film), a TV film based on a novel by Danielle Steele (see below)
• Once in a Lifetime, a 1995 Hong Kong film starring Sean Lau
• Once in a Lifetime (2000 film) (Livet är en schlager), a Swedish film
• Once in a Lifetime (2014 film), a French film
• Once in a Lifetime: The Extraordinary Story of the New York Cosmos, a 2006 documentary
• "Once in a Lifetime" (Ally McBeal), a 1998 TV episode
• "Once in a Lifetime" (Eureka), a 2006 TV episode

• Once in a Lifetime (Blutengel album), 2013
• Once in a Lifetime (David Meece album), 1993
• Once in a Lifetime (Runrig album), 1988
• Once in a Lifetime (Talking Heads album), a box set by Talking Heads
• Once in a Lifetime: The Best of Talking Heads, a compilation album by Talking Heads
• Once in a Lifetime Original Soundtrack, a soundtrack album from the 2006 documentary
• Once in a Lifetime, a 2010 compilation album by Sodagreen

• "Once in a Lifetime" (Keith Urban song), 2006
• "Once in a Lifetime" (Talking Heads song), 1980
• "To nie ja!", a song by Edyta Górniak, released in English as "Once in a Lifetime", 1994
• "Once in a Lifetime", the Estonian entry in the Eurovision Song Contest 2000
• "Once in a Lifetime", a song by 12 Stones from Anthem for the Underdog
• "Once in a Lifetime", a song by All Time Low
• "Once in a Lifetime", a song by Bananarama from Wow!
• "Once in a Lifetime", a song by Beyoncé Knowles from Cadillac Records: Music from the Motion Picture
• "Once in a Lifetime", a song by Chicago from Chicago 17
• "Once in a Lifetime", a song by Craig David from Born to Do It
• "Once in a Lifetime", a song by Dragonforce from Sonic Firestorm
• "Once in a Lifetime", a song by Flo Rida from My House
• "Once in a Lifetime", a song by Full Intention
• "Once in a Lifetime", a song by Gregorian from Sadisfaction
• "Once in a Lifetime", a song by Kansas from In the Spirit of Things
• "Once in a Lifetime", a song by Michael Bolton from the 1994 film Only You
• "Once in a Lifetime", a song by Monica from Still Standing
• "Once in a Lifetime", a song by Oleta Adams from Moving On
• "Once in a Lifetime", a song by One Direction from Four
• "Once in a Lifetime", a song by Wolfsheim from Spectators
• "Once in a Lifetime", a song from the stage musical Stop the World – I Want to Get Off
• "Once in a Lifetime Love", a song by Clay Walker

• Once in a Lifetime (play), a 1930 comedy by George S. Kaufman and Moss Hart
• Once in a Lifetime, a 1982 novel by Danielle Steel
• Once in a Lifetime, a performance DVD by Howard Morrison
• Once in a Lifetime, the tagline for the wrestling match between The Rock and John Cena at WrestleMania XXVIII

• Once in a LIVEtime, a 1998 live album by Dream Theater
• Twice in a Lifetime (disambiguation)

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