PAPSS1

{{Short description|Protein-coding gene in the species Homo sapiens}}

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an enzyme that in humans is encoded by the PAPSS1 gene.{{cite journal | vauthors = Girard JP, Baekkevold ES, Amalric F | title = Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase | journal = FASEB Journal | volume = 12 | issue = 7 | pages = 603–612 | date = May 1998 | pmid = 9576487 | doi = 10.1096/fasebj.12.7.603 | s2cid = 19530341 | doi-access = free }}{{cite journal | vauthors = Faiyaz ul Haque M, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH | display-authors = 6 | title = Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse | journal = Nature Genetics | volume = 20 | issue = 2 | pages = 157–162 | date = October 1998 | pmid = 9771708 | doi = 10.1038/2458 | s2cid = 13108930 }}{{cite web | title = Entrez Gene: PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9061}}

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM]{{cite web | title = Entrez Gene: PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9061}}

References

{{cite journal | vauthors = Venkatachalam KV | title = Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency | journal = IUBMB Life | volume = 55 | issue = 1 | pages = 1–11 | date = January 2003 | pmid = 12716056 | doi = 10.1080/1521654031000072148 | s2cid = 37733913 | doi-access = free }}
{{cite journal | vauthors = Yanagisawa K, Sakakibara Y, Suiko M, Takami Y, Nakayama T, Nakajima H, Takayanagi K, Natori Y, Liu MC | display-authors = 6 | title = cDNA cloning, expression, and characterization of the human bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase enzyme | journal = Bioscience, Biotechnology, and Biochemistry | volume = 62 | issue = 5 | pages = 1037–1040 | date = May 1998 | pmid = 9648242 | doi = 10.1271/bbb.62.1037 | doi-access = free }}
{{cite journal | vauthors = Venkatachalam KV, Akita H, Strott CA | title = Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains | journal = The Journal of Biological Chemistry | volume = 273 | issue = 30 | pages = 19311–19320 | date = July 1998 | pmid = 9668121 | doi = 10.1074/jbc.273.30.19311 | doi-access = free }}
{{cite journal | vauthors = Kurima K, Warman ML, Krishnan S, Domowicz M, Krueger RC, Deyrup A, Schwartz NB | title = A member of a family of sulfate-activating enzymes causes murine brachymorphism | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8681–8685 | date = July 1998 | pmid = 9671738 | pmc = 21136 | doi = 10.1073/pnas.95.15.8681 | doi-access = free | bibcode = 1998PNAS...95.8681K }}
{{cite journal | vauthors = Venkatachalam KV, Fuda H, Koonin EV, Strott CA | title = Site-selected mutagenesis of a conserved nucleotide binding HXGH motif located in the ATP sulfurylase domain of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase | journal = The Journal of Biological Chemistry | volume = 274 | issue = 5 | pages = 2601–2604 | date = January 1999 | pmid = 9915785 | doi = 10.1074/jbc.274.5.2601 | doi-access = free }}
{{cite journal | vauthors = Besset S, Vincourt JB, Amalric F, Girard JP | title = Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells | journal = FASEB Journal | volume = 14 | issue = 2 | pages = 345–354 | date = February 2000 | pmid = 10657990 | doi = 10.1096/fasebj.14.2.345 | s2cid = 9024784 | doi-access = free }}
{{cite journal | vauthors = Xu ZH, Otterness DM, Freimuth RR, Carlini EJ, Wood TC, Mitchell S, Moon E, Kim UJ, Xu JP, Siciliano MJ, Weinshilboum RM | display-authors = 6 | title = Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization | journal = Biochemical and Biophysical Research Communications | volume = 268 | issue = 2 | pages = 437–444 | date = February 2000 | pmid = 10679223 | doi = 10.1006/bbrc.2000.2123 }}
{{cite journal | vauthors = Fuda H, Shimizu C, Lee YC, Akita H, Strott CA | title = Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms | journal = The Biochemical Journal | volume = 365 | issue = Pt 2 | pages = 497–504 | date = July 2002 | pmid = 11931637 | pmc = 1222679 | doi = 10.1042/BJ20020044 }}
{{cite journal | vauthors = Harjes S, Scheidig A, Bayer P | title = Expression, purification and crystallization of human 3'-phosphoadenosine-5'-phosphosulfate synthetase 1 | journal = Acta Crystallographica. Section D, Biological Crystallography | volume = 60 | issue = Pt 2 | pages = 350–352 | date = February 2004 | pmid = 14747722 | doi = 10.1107/S0907444903027628 }}
{{cite journal | vauthors = Lansdon EB, Fisher AJ, Segel IH | title = Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains | journal = Biochemistry | volume = 43 | issue = 14 | pages = 4356–4365 | date = April 2004 | pmid = 15065880 | doi = 10.1021/bi049827m }}
{{cite journal | vauthors = Harjes S, Bayer P, Scheidig AJ | title = The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate binding | journal = Journal of Molecular Biology | volume = 347 | issue = 3 | pages = 623–635 | date = April 2005 | pmid = 15755455 | doi = 10.1016/j.jmb.2005.01.005 }}
{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | display-authors = 6 | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–968 | date = September 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 | hdl-access = free | s2cid = 8235923 | hdl = 11858/00-001M-0000-0010-8592-0 }}
{{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | display-authors = 6 | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
{{cite journal | vauthors = Sekulic N, Konrad M, Lavie A | title = Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation | journal = The Journal of Biological Chemistry | volume = 282 | issue = 30 | pages = 22112–22121 | date = July 2007 | pmid = 17540769 | doi = 10.1074/jbc.M701713200 | hdl-access = free | doi-access = free | hdl = 11858/00-001M-0000-0012-E08D-D }}

PAPSS1

References

Further reading