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PCBP1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.{{cite journal | vauthors = Tommerup N, Leffers H | title = Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A | journal = Genomics | volume = 32 | issue = 2 | pages = 297–8 |date=May 1997 | pmid = 8833161 | doi = 10.1006/geno.1996.0121 }}

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP2 and HNRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.

It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.{{cite web | title = Entrez Gene: PCBP1 poly(rC) binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5093}}

References

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Further reading

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  • {{cite journal | vauthors=Kiledjian M, Wang X, Liebhaber SA |title=Identification of two KH domain proteins in the alpha-globin mRNP stability complex. |journal=EMBO J. |volume=14 |issue= 17 |pages= 4357–64 |year= 1995 |pmid= 7556077 |doi= 10.1002/j.1460-2075.1995.tb00110.x| pmc=394520 }}
  • {{cite journal | vauthors=Leffers H, Dejgaard K, Celis JE |title=Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains. |journal=Eur. J. Biochem. |volume=230 |issue= 2 |pages= 447–53 |year= 1995 |pmid= 7607214 |doi=10.1111/j.1432-1033.1995.tb20581.x }}
  • {{cite journal | vauthors=Aasheim HC, Loukianova T, Deggerdal A, Smeland EB |title=Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K. |journal=Nucleic Acids Res. |volume=22 |issue= 6 |pages= 959–64 |year= 1994 |pmid= 8152927 |doi=10.1093/nar/22.6.959 | pmc=307915 }}
  • {{cite journal |vauthors=Blyn LB, Swiderek KM, Richards O, etal |title=Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 20 |pages= 11115–20 |year= 1996 |pmid= 8855318 |doi=10.1073/pnas.93.20.11115 | pmc=38293 |bibcode=1996PNAS...9311115B |doi-access=free }}
  • {{cite journal | vauthors=Kiledjian M, DeMaria CT, Brewer G, Novick K |title=Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex. |journal=Mol. Cell. Biol. |volume=17 |issue= 8 |pages= 4870–6 |year= 1997 |pmid= 9234743 |doi= 10.1128/MCB.17.8.4870| pmc=232339 }}
  • {{cite journal | vauthors=Wang Z, Day N, Trifillis P, Kiledjian M |title=An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4552–60 |year= 1999 |pmid= 10373504 |doi= 10.1128/MCB.19.7.4552| pmc=84253 }}
  • {{cite journal | vauthors=Makeyev AV, Chkheidze AN, Liebhaber SA |title=A set of highly conserved RNA-binding proteins, alphaCP-1 and alphaCP-2, implicated in mRNA stabilization, are coexpressed from an intronless gene and its intron-containing paralog. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24849–57 |year= 1999 |pmid= 10455157 |doi=10.1074/jbc.274.35.24849 |doi-access=free }}
  • {{cite journal | vauthors=Makeyev AV, Liebhaber SA |title=Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins. |journal=Genomics |volume=67 |issue= 3 |pages= 301–16 |year= 2000 |pmid= 10936052 |doi= 10.1006/geno.2000.6244 }}
  • {{cite journal |vauthors=Suzuki H, Fukunishi Y, Kagawa I, etal |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 | pmc=311163 }}
  • {{cite journal |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |s2cid=14132033 |doi-access=free |bibcode=2002CBio...12....1A }}
  • {{cite journal |vauthors=Yeap BB, Voon DC, Vivian JP, etal |title=Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27183–92 |year= 2002 |pmid= 12011088 |doi= 10.1074/jbc.M202883200 |doi-access= free }}
  • {{cite journal | vauthors=Walter BL, Parsley TB, Ehrenfeld E, Semler BL |title=Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. |journal=J. Virol. |volume=76 |issue= 23 |pages= 12008–22 |year= 2002 |pmid= 12414943 |doi=10.1128/JVI.76.23.12008-12022.2002 | pmc=136902 }}
  • {{cite journal |vauthors=Giles KM, Daly JM, Beveridge DJ, etal |title=The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 2937–46 |year= 2003 |pmid= 12431987 |doi= 10.1074/jbc.M208439200 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Pickering BM, Mitchell SA, Evans JR, Willis AE |title=Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo. |journal=Nucleic Acids Res. |volume=31 |issue= 2 |pages= 639–46 |year= 2003 |pmid= 12527772 |doi=10.1093/nar/gkg146 | pmc=140511 }}
  • {{cite journal |vauthors=Pillai MR, Chacko P, Kesari LA, etal |title=Expression of folate receptors and heterogeneous nuclear ribonucleoprotein E1 in women with human papillomavirus mediated transformation of cervical tissue to cancer. |journal=J. Clin. Pathol. |volume=56 |issue= 8 |pages= 569–74 |year= 2003 |pmid= 12890803 |doi=10.1136/jcp.56.8.569 | pmc=1770025 }}
  • {{cite journal |vauthors=Adams DJ, Beveridge DJ, van der Weyden L, etal |title=HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44894–903 |year= 2004 |pmid= 12933794 |doi= 10.1074/jbc.M307782200 |doi-access= free }}
  • {{cite journal |vauthors=Evans JR, Mitchell SA, Spriggs KA, etal |title=Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo. |journal=Oncogene |volume=22 |issue= 39 |pages= 8012–20 |year= 2003 |pmid= 12970749 |doi= 10.1038/sj.onc.1206645 |s2cid=24731120 |doi-access= }}
  • {{cite journal | vauthors=Chkheidze AN, Liebhaber SA |title=A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 23 |pages= 8405–15 |year= 2003 |pmid= 14612387 |doi=10.1128/MCB.23.23.8405-8415.2003 | pmc=262676 }}

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