PCK1

This enzyme is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.

{{GlycolysisGluconeogenesis_WP534|highlight=PCK1}}

• PEPCK

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• {{cite journal | vauthors=Beale EG, Hammer RE, Antoine B, Forest C |title=Disregulated glyceroneogenesis: PCK1 as a candidate diabetes and obesity gene. |journal=Trends Endocrinol. Metab. |volume=15 |issue= 3 |pages= 129–35 |year= 2004 |pmid= 15046742 |doi= 10.1016/j.tem.2004.02.006 |title-link=glyceroneogenesis |s2cid=9194909 }}
• {{cite journal | vauthors=Pilz AJ, Willer E, Povey S, Abbott CM |title=The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2. |journal=Ann. Hum. Genet. |volume=56 |issue= Pt 4 |pages= 289–93 |year= 1993 |pmid= 1492743 |doi=10.1111/j.1469-1809.1992.tb01155.x |s2cid=23586336 }}
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• {{cite journal | vauthors=Jurado LA, Song S, Roesler WJ, Park EA |title=Conserved amino acids within CCAAT enhancer-binding proteins (C/EBP(alpha) and beta) regulate phosphoenolpyruvate carboxykinase (PEPCK) gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27606–12 |year= 2002 |pmid= 11997389 |doi= 10.1074/jbc.M201429200 |doi-access= free }}
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• {{cite journal |vauthors=Chakravarty K, Wu SY, Chiang CM, etal |title=SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15385–95 |year= 2004 |pmid= 14744869 |doi= 10.1074/jbc.M309905200 |doi-access= free }}
• {{cite journal |vauthors=Cao H, van der Veer E, Ban MR, etal |title=Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 2 |pages= 898–903 |year= 2004 |pmid= 14764811 |doi=10.1210/jc.2003-031361 |doi-access=free }}
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• {{cite journal | vauthors=Hajarnis S, Schroeder JM, Curthoys NP |title=3'-Untranslated region of phosphoenolpyruvate carboxykinase mRNA contains multiple instability elements that bind AUF1. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28272–80 |year= 2005 |pmid= 15951444 |doi= 10.1074/jbc.M501204200 |doi-access= free }}

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