Login
Login

PEA15

{{cs1 config|name-list-style=vanc}}

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.{{cite journal | vauthors = Hwang S, Kuo WL, Cochran JF, Guzman RC, Tsukamoto T, Bandyopadhyay G, Myambo K, Collins CC | title = Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers | journal = Genomics | volume = 42 | issue = 3 | pages = 540–2 | date = September 1997 | pmid = 9205133 | doi = 10.1006/geno.1997.4768 }}{{cite web | title = Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8682}}

PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.

PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.{{cite journal | vauthors = Böck BC, Tagscherer KE, Fassl A, Krämer A, Oehme I, Zentgraf HW, Keith M, Roth W | title = The PEA-15 protein regulates autophagy via activation of JNK | journal = J. Biol. Chem. | volume = 285 | issue = 28 | pages = 21644–54 | date = July 2010 | pmid = 20452983 | pmc = 2898427 | doi = 10.1074/jbc.M109.096628 | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=20452983 | doi-access = free }}

Interactions

PEA15 has been shown to interact with:

  • Caspase 8,{{cite journal | vauthors = Kitsberg D, Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, Pan G, Rolli M, Glowinski J, Chneiweiss H | title = Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis | journal = J. Neurosci. | volume = 19 | issue = 19 | pages = 8244–51 | date = October 1999 | pmid = 10493725 | doi = 10.1523/JNEUROSCI.19-19-08244.1999 | pmc = 6783010}}{{cite journal | vauthors = Condorelli G, Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F | title = PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis | journal = Oncogene | volume = 18 | issue = 31 | pages = 4409–15 | date = August 1999 | pmid = 10442631 | doi = 10.1038/sj.onc.1202831 | s2cid = 20510429 }}
  • FADD, and
  • MAPK1,{{cite journal | vauthors = Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H | title = PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase | journal = Dev. Cell | volume = 1 | issue = 2 | pages = 239–50 | date = August 2001 | pmid = 11702783 | doi = 10.1016/s1534-5807(01)00035-1| doi-access = free }}
  • Phospholipase D1,{{cite journal | vauthors = Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA | title = Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 35224–32 | date = November 2000 | pmid = 10926929 | doi = 10.1074/jbc.M003329200 | doi-access = free}} and
  • RPS6KA3.{{cite journal | vauthors = Vaidyanathan H, Ramos JW | title = RSK2 activity is regulated by its interaction with PEA-15 | journal = J. Biol. Chem. | volume = 278 | issue = 34 | pages = 32367–72 | date = August 2003 | pmid = 12796492 | doi = 10.1074/jbc.M303988200 | doi-access = free }}

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors = Araujo H, Danziger N, Cordier J, Glowinski J, Chneiweiss H | title = Characterization of PEA-15, a major substrate for protein kinase C in astrocytes | journal = J. Biol. Chem. | volume = 268 | issue = 8 | pages = 5911–20 | year = 1993 | doi = 10.1016/S0021-9258(18)53407-4 | pmid = 8449955 | doi-access = free }}
  • {{cite journal | vauthors = Estellés A, Yokoyama M, Nothias F, Vincent JD, Glowinski J, Vernier P, Chneiweiss H | title = The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human | journal = J. Biol. Chem. | volume = 271 | issue = 25 | pages = 14800–6 | year = 1996 | pmid = 8662970 | doi = 10.1074/jbc.271.25.14800 | doi-access = free }}
  • {{cite journal | vauthors = Condorelli G, Vigliotta G, Iavarone C, Caruso M, Tocchetti CG, Andreozzi F, Cafieri A, Tecce MF, Formisano P, Beguinot L, Beguinot F | title = PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus | journal = EMBO J. | volume = 17 | issue = 14 | pages = 3858–66 | year = 1998 | pmid = 9670003 | pmc = 1170721 | doi = 10.1093/emboj/17.14.3858 }}
  • {{cite journal | vauthors = Kubes M, Cordier J, Glowinski J, Girault JA, Chneiweiss H | title = Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro | journal = J. Neurochem. | volume = 71 | issue = 3 | pages = 1307–14 | year = 1998 | pmid = 9721757 | doi = 10.1046/j.1471-4159.1998.71031307.x | doi-access = free }}
  • {{cite journal | vauthors = Condorelli G, Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F | title = PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis | journal = Oncogene | volume = 18 | issue = 31 | pages = 4409–15 | year = 1999 | pmid = 10442631 | doi = 10.1038/sj.onc.1202831 | s2cid = 20510429 }}
  • {{cite journal | vauthors = Kitsberg D, Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, Pan G, Rolli M, Glowinski J, Chneiweiss H | title = Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis | journal = J. Neurosci. | volume = 19 | issue = 19 | pages = 8244–51 | year = 1999 | pmid = 10493725 | doi = 10.1523/JNEUROSCI.19-19-08244.1999 | pmc = 6783010}}
  • {{cite journal | vauthors = Wolford JK, Bogardus C, Ossowski V, Prochazka M | title = Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians | journal = Gene | volume = 241 | issue = 1 | pages = 143–8 | year = 2000 | pmid = 10607908 | doi = 10.1016/S0378-1119(99)00455-2 | url = https://zenodo.org/record/1260057 }}
  • {{cite journal | vauthors = Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA | title = Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 35224–32 | year = 2001 | pmid = 10926929 | doi = 10.1074/jbc.M003329200 | doi-access = free}}
  • {{cite journal | vauthors = Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H | title = PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase | journal = Dev. Cell | volume = 1 | issue = 2 | pages = 239–50 | year = 2001 | pmid = 11702783 | doi = 10.1016/S1534-5807(01)00035-1 | doi-access = free }}
  • {{cite journal | vauthors = Condorelli G, Trencia A, Vigliotta G, Perfetti A, Goglia U, Cassese A, Musti AM, Miele C, Santopietro S, Formisano P, Beguinot F | title = Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function | journal = J. Biol. Chem. | volume = 277 | issue = 13 | pages = 11013–8 | year = 2002 | pmid = 11790785 | doi = 10.1074/jbc.M110934200 | doi-access = free }}
  • {{cite journal | vauthors = Xiao C, Yang BF, Asadi N, Beguinot F, Hao C | title = Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells | journal = J. Biol. Chem. | volume = 277 | issue = 28 | pages = 25020–5 | year = 2002 | pmid = 11976344 | doi = 10.1074/jbc.M202946200 | doi-access = free }}
  • {{cite journal | vauthors = Vaidyanathan H, Ramos JW | title = RSK2 activity is regulated by its interaction with PEA-15 | journal = J. Biol. Chem. | volume = 278 | issue = 34 | pages = 32367–72 | year = 2003 | pmid = 12796492 | doi = 10.1074/jbc.M303988200 | doi-access = free }}
  • {{cite journal | vauthors = Trencia A, Perfetti A, Cassese A, Vigliotta G, Miele C, Oriente F, Santopietro S, Giacco F, Condorelli G, Formisano P, Beguinot F | title = Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action | journal = Mol. Cell. Biol. | volume = 23 | issue = 13 | pages = 4511–21 | year = 2003 | pmid = 12808093 | pmc = 164852 | doi = 10.1128/MCB.23.13.4511-4521.2003 }}
  • {{cite journal | vauthors = Trencia A, Fiory F, Maitan MA, Vito P, Barbagallo AP, Perfetti A, Miele C, Ungaro P, Oriente F, Cilenti L, Zervos AS, Formisano P, Beguinot F | title = Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15 | journal = J. Biol. Chem. | volume = 279 | issue = 45 | pages = 46566–72 | year = 2004 | pmid = 15328349 | doi = 10.1074/jbc.M406317200 | doi-access = free }}
  • {{cite journal | vauthors = Gaumont-Leclerc MF, Mukhopadhyay UK, Goumard S, Ferbeyre G | title = PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence | journal = J. Biol. Chem. | volume = 279 | issue = 45 | pages = 46802–9 | year = 2004 | pmid = 15331596 | doi = 10.1074/jbc.M403893200 | doi-access = free }}
  • {{cite journal | vauthors = Renganathan H, Vaidyanathan H, Knapinska A, Ramos JW | title = Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD | journal = Biochem. J. | volume = 390 | issue = Pt 3 | pages = 729–35 | year = 2006 | pmid = 15916534 | pmc = 1199667 | doi = 10.1042/BJ20050378 }}

{{refend}}

{{PDB Gallery|geneid=8682}}

{{gene-1-stub}}