RPS6KA3

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.

Mutations in this gene have been associated with Coffin–Lowry syndrome (CLS).{{cite journal | vauthors = Jacquot S, Zeniou M, Touraine R, Hanauer A | title = X-linked Coffin-Lowry syndrome (CLS, MIM 303600, RPS6KA3 gene, protein product known under various names: pp90(rsk2), RSK2, ISPK, MAPKAP1) | journal = European Journal of Human Genetics | volume = 10 | issue = 1 | pages = 2–5 | date = January 2002 | pmid = 11896450 | doi = 10.1038/sj.ejhg.5200738 | doi-access = free }}

RPS6KA3 has been shown to interact with CREB-binding protein,{{cite journal | vauthors = Merienne K, Pannetier S, Harel-Bellan A, Sassone-Corsi P | title = Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities | journal = Molecular and Cellular Biology | volume = 21 | issue = 20 | pages = 7089–96 | date = October 2001 | pmid = 11564891 | pmc = 99884 | doi = 10.1128/MCB.21.20.7089-7096.2001 }} MAPK1{{cite journal | vauthors = Zhao Y, Bjorbaek C, Moller DE | title = Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases | journal = The Journal of Biological Chemistry | volume = 271 | issue = 47 | pages = 29773–9 | date = November 1996 | pmid = 8939914 | doi = 10.1074/jbc.271.47.29773 | doi-access =free }}{{cite journal | vauthors = Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW | title = Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo | journal = The Journal of Biological Chemistry | volume = 274 | issue = 5 | pages = 2893–8 | date = January 1999 | pmid = 9915826 | doi = 10.1074/jbc.274.5.2893 | doi-access = free }} and PEA15.{{cite journal | vauthors = Vaidyanathan H, Ramos JW | title = RSK2 activity is regulated by its interaction with PEA-15 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 34 | pages = 32367–72 | date = August 2003 | pmid = 12796492 | doi = 10.1074/jbc.M303988200 | doi-access = free }}

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{{Refend}}

• [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cls GeneReviews/NCBI/NIH/UW entry on Coffin–Lowry syndrome]

{{Serine/threonine-specific protein kinases}}

{{Enzymes}}

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Category:EC 2.7.11