PIGH
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene.{{cite journal |vauthors=Ware RE, Howard TA, Kamitani T, Change HM, Yeh ET, Seldin MF | title = Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria | journal = Blood | volume = 83 | issue = 12 | pages = 3753–7 |date=Jul 1994 | doi = 10.1182/blood.V83.12.3753.3753 | pmid = 8204896 | doi-access = free }}{{cite web | title = Entrez Gene: PIGH phosphatidylinositol glycan anchor biosynthesis, class H| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5283}} The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.{{cite web|title=AceView: Homo sapiens gene PIGH|url=https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=PIGH&submit=Go|work=AceView|publisher=National Library of Medicine|access-date=24 April 2011}}
This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.
Interactions
PIGH has been shown to interact with PIGQ.{{cite journal |last=Watanabe |first=R |author2=Inoue N |author3=Westfall B |author4=Taron C H |author5=Orlean P |author6=Takeda J |author7=Kinoshita T |date=Feb 1998 |title=The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1 |journal=EMBO J. |volume=17 |issue=4 |pages=877–85 |location = ENGLAND| issn = 0261-4189| pmid = 9463366 |doi = 10.1093/emboj/17.4.877 |pmc=1170437 }}
References
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Further reading
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- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Watanabe R, Inoue N, Westfall B, etal |title=The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1 |journal=EMBO J. |volume=17 |issue= 4 |pages= 877–85 |year= 1998 |pmid= 9463366 |doi= 10.1093/emboj/17.4.877 | pmc=1170437 }}
- {{cite journal |vauthors=Watanabe R, Kinoshita T, Masaki R, etal |title=PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 26868–75 |year= 1996 |pmid= 8900170 |doi=10.1074/jbc.271.43.26868 |doi-access=free }}
- {{cite journal |vauthors=Kamitani T, Chang HM, Rollins C, etal |title=Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 20733–6 |year= 1993 |doi=10.1016/S0021-9258(19)36842-5 |pmid= 8407896 |doi-access=free }}
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