PJA1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.{{cite journal | vauthors = Yu P, Chen Y, Tagle DA, Cai T | title = PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain | journal = Genomics | volume = 79 | issue = 6 | pages = 869–74 | date = June 2002 | pmid = 12036302 | doi = 10.1006/geno.2002.6770 | url = https://zenodo.org/record/1229812 }}{{cite web | title = Entrez Gene: PJA1 praja 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64219}}
Interactions
PJA1 has been shown to interact with UBE2D2 and MAGED1.{{cite journal | vauthors = Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K | title = A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 25 | pages = 22541–6 | date = June 2002 | pmid = 11959851 | doi = 10.1074/jbc.M109728200 | doi-access = free }}
References
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Further reading
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- {{cite journal | vauthors = Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, Mezey E, Pavan WJ, Mishra B | display-authors = 6 | title = Praja1, a novel gene encoding a RING-H2 motif in mouse development | journal = Oncogene | volume = 15 | issue = 19 | pages = 2361–8 | date = November 1997 | pmid = 9393880 | doi = 10.1038/sj.onc.1201405 | doi-access = free }}
- {{cite journal | vauthors = Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM | title = Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 12 | pages = 8945–51 | date = March 2000 | pmid = 10722742 | doi = 10.1074/jbc.275.12.8945 | doi-access = free }}
- {{cite journal | vauthors = Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K | title = A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 25 | pages = 22541–6 | date = June 2002 | pmid = 11959851 | doi = 10.1074/jbc.M109728200 | doi-access = free }}
- {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | display-authors = 6 | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
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