UBE2D2

Modifying proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s; ubiquitin-conjugating enzymes, or E2s; and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene, and they encode distinct isoforms.

UBE2D2 has been shown to interact with:

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• Baculoviral IAP repeat-containing protein 3,{{cite journal | vauthors = Mace PD, Linke K, Feltham R, Schumacher FR, Smith CA, Vaux DL, Silke J, Day CL | title = Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment | journal = The Journal of Biological Chemistry | volume = 283 | issue = 46 | pages = 31633–40 | date = Nov 2008 | pmid = 18784070 | doi = 10.1074/jbc.M804753200 | doi-access = free }}
• NEDD4,
• PJA1,{{cite journal | vauthors = Yu P, Chen Y, Tagle DA, Cai T | title = PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain | journal = Genomics | volume = 79 | issue = 6 | pages = 869–74 | date = Jun 2002 | pmid = 12036302 | doi = 10.1006/geno.2002.6770 | url = https://zenodo.org/record/1229812 }}
• PJA2, and
• UBE3A.{{cite journal | vauthors = Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M | title = Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes | journal = Genes to Cells | volume = 3 | issue = 11 | pages = 751–63 | date = Nov 1998 | pmid = 9990509 | doi = 10.1046/j.1365-2443.1998.00227.x| s2cid = 1653536 }}{{cite journal | vauthors = Hatakeyama S, Jensen JP, Weissman AM | title = Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases | journal = The Journal of Biological Chemistry | volume = 272 | issue = 24 | pages = 15085–92 | date = Jun 1997 | pmid = 9182527 | doi = 10.1074/jbc.272.24.15085| doi-access = free }}

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{{Reflist}}

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• {{cite journal | vauthors = Rolfe M, Beer-Romero P, Glass S, Eckstein J, Berdo I, Theodoras A, Pagano M, Draetta G | title = Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 8 | pages = 3264–8 | date = Apr 1995 | pmid = 7724550 | pmc = 42146 | doi = 10.1073/pnas.92.8.3264 | bibcode = 1995PNAS...92.3264R | doi-access = free }}
• {{cite journal | vauthors = Scheffner M, Huibregtse JM, Howley PM | title = Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 19 | pages = 8797–801 | date = Sep 1994 | pmid = 8090726 | pmc = 44693 | doi = 10.1073/pnas.91.19.8797 | bibcode = 1994PNAS...91.8797S | doi-access = free }}
• {{cite journal | vauthors = Hatakeyama S, Jensen JP, Weissman AM | title = Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases | journal = The Journal of Biological Chemistry | volume = 272 | issue = 24 | pages = 15085–92 | date = Jun 1997 | pmid = 9182527 | doi = 10.1074/jbc.272.24.15085 | doi-access = free }}
• {{cite journal | vauthors = Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M | title = Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes | journal = Genes to Cells | volume = 3 | issue = 11 | pages = 751–63 | date = Nov 1998 | pmid = 9990509 | doi = 10.1046/j.1365-2443.1998.00227.x | s2cid = 1653536 }}
• {{cite journal | vauthors = Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A | title = Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha | journal = The Journal of Biological Chemistry | volume = 274 | issue = 21 | pages = 14823–30 | date = May 1999 | pmid = 10329681 | doi = 10.1074/jbc.274.21.14823 | doi-access = free }}
• {{cite journal | vauthors = Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC | title = The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase | journal = Science | volume = 286 | issue = 5438 | pages = 309–12 | date = Oct 1999 | pmid = 10514377 | doi = 10.1126/science.286.5438.309 }}
• {{cite journal | vauthors = Tongaonkar P, Chen L, Lambertson D, Ko B, Madura K | title = Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome | journal = Molecular and Cellular Biology | volume = 20 | issue = 13 | pages = 4691–8 | date = Jul 2000 | pmid = 10848595 | pmc = 85887 | doi = 10.1128/MCB.20.13.4691-4698.2000 }}
• {{cite journal | vauthors = Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, Glass S, Parsons T, Copeland RA, Auger KR, Benfield P, Brizuela L, Rolfe M | title = SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4 | journal = Oncogene | volume = 19 | issue = 31 | pages = 3529–36 | date = Jul 2000 | pmid = 10918611 | doi = 10.1038/sj.onc.1203647 | s2cid = 24267499 | doi-access = }}
• {{cite journal | vauthors = Fang S, Ferrone M, Yang C, Jensen JP, Tiwari S, Weissman AM | title = The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 25 | pages = 14422–7 | date = Dec 2001 | pmid = 11724934 | pmc = 64697 | doi = 10.1073/pnas.251401598 | bibcode = 2001PNAS...9814422F | doi-access = free }}
• {{cite journal | vauthors = Yu P, Chen Y, Tagle DA, Cai T | title = PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain | journal = Genomics | volume = 79 | issue = 6 | pages = 869–74 | date = Jun 2002 | pmid = 12036302 | doi = 10.1006/geno.2002.6770 | url = https://zenodo.org/record/1229812 }}
• {{cite journal | vauthors = Xia Y, Pao GM, Chen HW, Verma IM, Hunter T | title = Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein | journal = The Journal of Biological Chemistry | volume = 278 | issue = 7 | pages = 5255–63 | date = Feb 2003 | pmid = 12431996 | doi = 10.1074/jbc.M204591200 | doi-access = free }}
• {{cite journal | vauthors = Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA | title = The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 24 | pages = 21930–7 | date = Jun 2003 | pmid = 12670957 | doi = 10.1074/jbc.M301157200 | doi-access = free }}
• {{cite journal | vauthors = Xu L, Yang L, Moitra PK, Hashimoto K, Rallabhandi P, Kaul S, Meroni G, Jensen JP, Weissman AM, D'Arpa P | title = BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta | journal = Experimental Cell Research | volume = 288 | issue = 1 | pages = 84–93 | date = Aug 2003 | pmid = 12878161 | doi = 10.1016/S0014-4827(03)00187-3 }}
• {{cite journal | vauthors = Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A | title = The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase | journal = British Journal of Cancer | volume = 89 | issue = 8 | pages = 1538–44 | date = Oct 2003 | pmid = 14562029 | pmc = 2394340 | doi = 10.1038/sj.bjc.6601301 }}
• {{cite journal | vauthors = Shimura H, Schwartz D, Gygi SP, Kosik KS | title = CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4869–76 | date = Feb 2004 | pmid = 14612456 | doi = 10.1074/jbc.M305838200 | doi-access =free }}
• {{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | date = Jan 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }}
• {{cite journal | vauthors = Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT | title = An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair | journal = Journal of Molecular Biology | volume = 337 | issue = 1 | pages = 157–65 | date = Mar 2004 | pmid = 15001359 | doi = 10.1016/j.jmb.2004.01.031 }}

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{{Ubiquitin-conjugating enzymes}}

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