POLR1C
{{short description|Protein-coding gene in the species Homo sapiens}}
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{{Infobox_gene}}
DNA-directed RNA polymerases I and III subunit RPAC1 is a protein that in humans is encoded by the POLR1C gene.{{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Research | volume = 10 | issue = 10 | pages = 1546–60 | date = Oct 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}{{cite journal | vauthors = Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T | title = A kinetic framework for a mammalian RNA polymerase in vivo | journal = Science | volume = 298 | issue = 5598 | pages = 1623–6 | date = Nov 2002 | pmid = 12446911 | doi = 10.1126/science.1076164 | bibcode = 2002Sci...298.1623D | s2cid = 36392120 }}{{cite web | title = Entrez Gene: POLR1C polymerase (RNA) I polypeptide C, 30kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9533}}
Interactions
POLR1C has been shown to interact with CD3EAP,{{cite journal | vauthors = Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M | title = Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription | journal = Molecular and Cellular Biology | volume = 24 | issue = 14 | pages = 6338–49 | date = Jul 2004 | pmid = 15226435 | pmc = 434256 | doi = 10.1128/MCB.24.14.6338-6349.2004 }} POLR1E{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}{{cite journal | vauthors = Seither P, Zatsepina O, Hoffmann M, Grummt I | title = Constitutive and strong association of PAF53 with RNA polymerase I | journal = Chromosoma | volume = 106 | issue = 4 | pages = 216–25 | date = Sep 1997 | pmid = 9254723 | doi = 10.1007/s004120050242 | s2cid = 23487728 }} and POLR1D.{{cite journal | vauthors = Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M | title = Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III | journal = The Journal of Biological Chemistry | volume = 271 | issue = 51 | pages = 32881–5 | date = Dec 1996 | pmid = 8955128 | doi = 10.1074/jbc.271.51.32881 | doi-access = free }}{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
References
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Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M | title = Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III | journal = The Journal of Biological Chemistry | volume = 271 | issue = 51 | pages = 32881–5 | date = Dec 1996 | pmid = 8955128 | doi = 10.1074/jbc.271.51.32881 | doi-access = free }}
- {{cite journal | vauthors = Seither P, Zatsepina O, Hoffmann M, Grummt I | title = Constitutive and strong association of PAF53 with RNA polymerase I | journal = Chromosoma | volume = 106 | issue = 4 | pages = 216–25 | date = Sep 1997 | pmid = 9254723 | doi = 10.1007/s004120050242 | s2cid = 23487728 }}
- {{cite journal | vauthors = Dammann R, Pfeifer GP | title = Cloning and characterization of the human RNA polymerase I subunit hRPA40 | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1396 | issue = 2 | pages = 153–7 | date = Mar 1998 | pmid = 9540830 | doi = 10.1016/s0167-4781(97)00206-6 }}
- {{cite journal | vauthors = Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z | title = Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 14 | pages = 8175–80 | date = Jul 1998 | pmid = 9653160 | pmc = 20949 | doi = 10.1073/pnas.95.14.8175 | bibcode = 1998PNAS...95.8175M | doi-access = free }}
- {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | s2cid = 14132033 | doi-access = free | bibcode = 2002CBio...12....1A }}
- {{cite journal | vauthors = Shiratori M, Suzuki T, Itoh C, Goto M, Furuichi Y, Matsumoto T | title = WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex | journal = Oncogene | volume = 21 | issue = 16 | pages = 2447–54 | date = Apr 2002 | pmid = 11971179 | doi = 10.1038/sj.onc.1205334 | doi-access = free }}
- {{cite journal | vauthors = Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N | title = Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits | journal = Molecular and Cellular Biology | volume = 22 | issue = 22 | pages = 8044–55 | date = Nov 2002 | pmid = 12391170 | pmc = 134740 | doi = 10.1128/MCB.22.22.8044-8055.2002 | url = http://repository.cshl.edu/28722/1/Kobayashi%20Myers%20Hernandez%20Molecular%20and%20Cellular%20Biology%202002.pdf }}
- {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = Feb 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 | s2cid = 11683986 }}
- {{cite journal | vauthors = Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M | title = Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription | journal = Molecular and Cellular Biology | volume = 24 | issue = 14 | pages = 6338–49 | date = Jul 2004 | pmid = 15226435 | pmc = 434256 | doi = 10.1128/MCB.24.14.6338-6349.2004 }}
- {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = Jan 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
- {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | bibcode = 2005Natur.433...77A | s2cid = 4344740 }}
- {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
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