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PPP1CB

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.{{cite journal |vauthors=Barker HM, Brewis ND, Street AJ, Spurr NK, Cohen PT | title = Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB) | journal = Biochim Biophys Acta | volume = 1220 | issue = 2 | pages = 212–8 | date=March 1994| pmid = 8312365 | doi =10.1016/0167-4889(94)90138-4 }}

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.{{cite web | title = Entrez Gene: PPP1CB protein phosphatase 1, catalytic subunit, beta isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5500}}

Interactions

PPP1CB has been shown to interact with PPP1R15A,{{cite journal |last=Wu |first=Daniel Y |author2=Tkachuck Douglas C |author3=Roberson Rachel S |author4=Schubach William H |date=August 2002|title=The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity |journal=J. Biol. Chem. |volume=277 |issue=31 |pages=27706–15 | issn = 0021-9258| pmid = 12016208 |doi = 10.1074/jbc.M200955200 |doi-access=free }}{{cite journal |last=Connor |first=J H |author2=Weiser D C |author3=Li S |author4=Hallenbeck J M |author5=Shenolikar S |date=October 2001|title=Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 |journal=Mol. Cell. Biol. |volume=21 |issue=20 |pages=6841–50 | issn = 0270-7306| pmid = 11564868 |doi = 10.1128/MCB.21.20.6841-6850.2001 |pmc=99861 }} Nucleolin,{{cite journal |last=Morimoto |first=Hiroyuki |author2=Okamura Hirohiko |author3=Haneji Tatsuji |date=September 2002|title=Interaction of protein phosphatase 1 delta with nucleolin in human osteoblastic cells |journal=J. Histochem. Cytochem. |volume=50 |issue=9 |pages=1187–93 | issn = 0022-1554| pmid = 12185196 |doi=10.1177/002215540205000905 |doi-access=free }} SMARCB1 and PPP1R9B.{{cite journal |last=Hsieh-Wilson |first=L C |author2=Allen P B |author3=Watanabe T |author4=Nairn A C |author5=Greengard P |date=April 1999|title=Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1 |journal=Biochemistry |volume=38 |issue=14 |pages=4365–73 | issn = 0006-2960| pmid = 10194355 |doi = 10.1021/bi982900m }}

References

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Further reading

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  • {{cite journal |vauthors=Prochazka M, Mochizuki H, Baier LJ, etal |title=Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians |journal=Diabetologia |volume=38 |issue= 4 |pages= 461–6 |year= 1995 |pmid= 7796987 |doi=10.1007/BF00410284 |doi-access=free }}
  • {{cite journal |vauthors=Saadat M, Kakinoki Y, Mizuno Y, etal |title=Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization |journal=Jpn. J. Genet. |volume=69 |issue= 6 |pages= 697–700 |year= 1995 |pmid= 7857673 |doi=10.1266/jjg.69.697 |doi-access=free }}
  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal |vauthors=Kawabe T, Muslin AJ, Korsmeyer SJ |title=HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint |journal=Nature |volume=385 |issue= 6615 |pages= 454–8 |year= 1997 |pmid= 9009195 |doi= 10.1038/385454a0 |bibcode=1997Natur.385..454K |s2cid=608633 }}
  • {{cite journal |vauthors=Fujioka M, Takahashi N, Odai H, etal |title=A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping |journal=Genomics |volume=49 |issue= 1 |pages= 59–68 |year= 1998 |pmid= 9570949 |doi= 10.1006/geno.1998.5222 }}
  • {{cite journal |vauthors=Verin AD, Csortos C, Durbin SD, etal |title=Characterization of the protein phosphatase 1 catalytic subunit in endothelium: involvement in contractile responses |journal=J. Cell. Biochem. |volume=79 |issue= 1 |pages= 113–25 |year= 2000 |pmid= 10906760 |doi=10.1002/1097-4644(2000)79:1<113::AID-JCB110>3.0.CO;2-9 |s2cid=42857803 }}
  • {{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
  • {{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
  • {{cite journal |vauthors=Tan I, Ng CH, Lim L, Leung T |title=Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21209–16 |year= 2001 |pmid= 11399775 |doi= 10.1074/jbc.M102615200 |doi-access= free }}
  • {{cite journal |vauthors=Fresu M, Bianchi M, Parsons JT, Villa-Moruzzi E |title=Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase |journal=Biochem. J. |volume=358 |issue= Pt 2 |pages= 407–14 |year= 2001 |pmid= 11513739 |doi=10.1042/0264-6021:3580407 | pmc=1222073 }}
  • {{cite journal |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |s2cid=14132033 |doi-access=free |bibcode=2002CBio...12....1A }}
  • {{cite journal |vauthors=Bharucha DC, Zhou M, Nekhai S, etal |title=A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat |journal=Virology |volume=296 |issue= 1 |pages= 6–16 |year= 2002 |pmid= 12036313 |doi= 10.1006/viro.2002.1438 |doi-access= free }}
  • {{cite journal |vauthors=Ceulemans H, Vulsteke V, De Maeyer M, etal |title=Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1 |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47331–7 |year= 2003 |pmid= 12226088 |doi= 10.1074/jbc.M206838200 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |s2cid=23783563 }}
  • {{cite journal |vauthors=Galey D, Becker K, Haughey N, etal |title=Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 358–71 |year= 2003 |pmid= 12775419 |doi=10.1080/13550280390201119 |s2cid=22016092 }}
  • {{cite journal |vauthors=Ammosova T, Jerebtsova M, Beullens M, etal |title=Nuclear protein phosphatase-1 regulates HIV-1 transcription |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32189–94 |year= 2003 |pmid= 12788939 |doi= 10.1074/jbc.M300521200 |doi-access= free }}
  • {{cite journal |vauthors=Llorian M, Beullens M, Andrés I, etal |title=SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1 |journal=Biochem. J. |volume=378 |issue= Pt 1 |pages= 229–38 |year= 2004 |pmid= 14640981 |doi= 10.1042/BJ20030950 | pmc=1223944 }}
  • {{cite journal |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |s2cid=11683986 }}

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