PPP1CC
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.{{cite web | title = Entrez Gene: PPP1CC Protein phosphatase 1, catalytic subunit, gamma isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5501| accessdate = }}
Interactions
PPP1CC has been shown to interact with PPP1R15A,{{cite journal |last=Wu |first=Daniel Y |author2=Tkachuck Douglas C |author3=Roberson Rachel S |author4=Schubach William H |date=Aug 2002 |title=The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity |journal=J. Biol. Chem. |volume=277 |issue=31 |pages=27706–15 |location = United States| issn = 0021-9258| pmid = 12016208 |doi = 10.1074/jbc.M200955200 |doi-access=free }}{{cite journal |last=Connor |first=J H |author2=Weiser D C |author3=Li S |author4=Hallenbeck J M |author5=Shenolikar S |date=Oct 2001 |title=Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 |journal=Mol. Cell. Biol. |volume=21 |issue=20 |pages=6841–50 |location = United States| issn = 0270-7306| pmid = 11564868 |doi = 10.1128/MCB.21.20.6841-6850.2001 |pmc=99861 }} SMARCB1, TLX1{{cite journal |last=Kawabe |first=T |author2=Muslin A J |author3=Korsmeyer S J |date=Jan 1997 |title=HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint |journal=Nature |volume=385 |issue=6615 |pages=454–8 |location = ENGLAND| issn = 0028-0836| pmid = 9009195 |doi = 10.1038/385454a0 | bibcode =1997Natur.385..454K |s2cid=608633 }} and PPP1R9B.{{cite journal |last=Hsieh-Wilson |first=L C |author2=Allen P B |author3=Watanabe T |author4=Nairn A C |author5=Greengard P |date=Apr 1999 |title=Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1 |journal=Biochemistry |volume=38 |issue=14 |pages=4365–73 |location = UNITED STATES| issn = 0006-2960| pmid = 10194355 |doi = 10.1021/bi982900m }}{{cite journal |doi=10.1074/jbc.274.28.19894 |last=Smith |first=F D |author2=Oxford G S |author3=Milgram S L |date=Jul 1999 |title=Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein |journal=J. Biol. Chem. |volume=274 |issue=28 |pages=19894–900 |location = UNITED STATES| issn = 0021-9258| pmid = 10391935 |doi-access=free }}
References
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Further reading
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- {{cite journal |vauthors=Van Eynde A, Wera S, Beullens M, etal |title=Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing. |journal=J. Biol. Chem. |volume=270 |issue= 47 |pages= 28068–74 |year= 1996 |pmid= 7499293 |doi=10.1074/jbc.270.47.28068 |doi-access=free }}
- {{cite journal |vauthors=Egloff MP, Cohen PT, Reinemer P, Barford D |title=Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate. |journal=J. Mol. Biol. |volume=254 |issue= 5 |pages= 942–59 |year= 1996 |pmid= 7500362 |doi= 10.1006/jmbi.1995.0667 }}
- {{cite journal |vauthors=MacKintosh RW, Dalby KN, Campbell DG, etal |title=The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. |journal=FEBS Lett. |volume=371 |issue= 3 |pages= 236–40 |year= 1995 |pmid= 7556599 |doi=10.1016/0014-5793(95)00888-G |s2cid=42021604 |doi-access=free }}
- {{cite journal |vauthors=Norman SA, Mott DM |title=Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA. |journal=Mamm. Genome |volume=5 |issue= 1 |pages= 41–5 |year= 1994 |pmid= 8111128 |doi=10.1007/BF00360567 |s2cid=21566111 |url=https://zenodo.org/record/1232415 }}
- {{cite journal |vauthors=Barker HM, Craig SP, Spurr NK, Cohen PT |title=Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2. |journal=Biochim. Biophys. Acta |volume=1178 |issue= 2 |pages= 228–33 |year= 1993 |pmid= 8394140 |doi=10.1016/0167-4889(93)90014-G }}
- {{cite journal |vauthors=Helps NR, Barker HM, Elledge SJ, Cohen PT |title=Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53. |journal=FEBS Lett. |volume=377 |issue= 3 |pages= 295–300 |year= 1996 |pmid= 8549741 |doi= 10.1016/0014-5793(95)01347-4 |s2cid=3010008 |doi-access=free }}
- {{cite journal |vauthors=Saadat M, Nomoto K, Mizuno Y, etal |title=Assignment of the gene encoding type 1 gamma protein phosphatase catalytic subunit (PPP1CC) on human, rat, and mouse chromosomes. |journal=Jpn. J. Hum. Genet. |volume=41 |issue= 1 |pages= 159–65 |year= 1996 |pmid= 8914631 |doi=10.1007/BF01892623 |doi-access=free }}
- {{cite journal |vauthors=Armstrong CG, Browne GJ, Cohen P, Cohen PT |title=PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1. |journal=FEBS Lett. |volume=418 |issue= 1–2 |pages= 210–4 |year= 1998 |pmid= 9414128 |doi=10.1016/S0014-5793(97)01385-9 |s2cid=21169749 }}
- {{cite journal |vauthors=Andreassen PR, Lacroix FB, Villa-Moruzzi E, Margolis RL |title=Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cells. |journal=J. Cell Biol. |volume=141 |issue= 5 |pages= 1207–15 |year= 1998 |pmid= 9606212 |doi=10.1083/jcb.141.5.1207 | pmc=2137188 }}
- {{cite journal |vauthors=Ajuh PM, Browne GJ, Hawkes NA, etal |title=Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex. |journal=Nucleic Acids Res. |volume=28 |issue= 3 |pages= 678–86 |year= 2000 |pmid= 10637318 |doi=10.1093/nar/28.3.678 | pmc=102561 }}
- {{cite journal |vauthors=Yang J, Hurley TD, DePaoli-Roach AA |title=Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22635–44 |year= 2000 |pmid= 10807923 |doi= 10.1074/jbc.M003082200 |doi-access= free }}
- {{cite journal |vauthors=Katayama H, Zhou H, Li Q, etal |title=Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46219–24 |year= 2002 |pmid= 11551964 |doi= 10.1074/jbc.M107540200 |doi-access= free }}
- {{cite journal |vauthors=Patel KG, Liu C, Cameron PL, Cameron RS |title=Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1. |journal=J. Neurosci. |volume=21 |issue= 20 |pages= 7954–68 |year= 2001 |pmid= 11588169 |doi= 10.1523/JNEUROSCI.21-20-07954.2001|doi-access=free |pmc=6763852 }}
- {{cite journal |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |s2cid=14132033 |doi-access=free |bibcode=2002CBio...12....1A }}
- {{cite journal |vauthors=Jones JA, Hannun YA |title=Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15530–8 |year= 2002 |pmid= 11856740 |doi= 10.1074/jbc.M111555200 |doi-access= free }}
- {{cite journal |vauthors=Wu DY, Tkachuck DC, Roberson RS, Schubach WH |title=The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27706–15 |year= 2002 |pmid= 12016208 |doi= 10.1074/jbc.M200955200 |doi-access= free }}
- {{cite journal |vauthors=Bharucha DC, Zhou M, Nekhai S, etal |title=A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat. |journal=Virology |volume=296 |issue= 1 |pages= 6–16 |year= 2002 |pmid= 12036313 |doi= 10.1006/viro.2002.1438 |doi-access= free }}
- {{cite journal |vauthors=Tan SL, Tareen SU, Melville MW, etal |title=The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36109–17 |year= 2002 |pmid= 12138106 |doi= 10.1074/jbc.M205109200 |doi-access= free }}
- {{cite journal |vauthors=Eto M, Elliott E, Prickett TD, Brautigan DL |title=Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44013–20 |year= 2003 |pmid= 12221103 |doi= 10.1074/jbc.M208035200 |doi-access= free }}
- {{cite journal |vauthors=Ceulemans H, Vulsteke V, De Maeyer M, etal |title=Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47331–7 |year= 2003 |pmid= 12226088 |doi= 10.1074/jbc.M206838200 |doi-access= free }}
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