PPP2CB

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.{{cite web | title = Entrez Gene: PPP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5516}}

PPP2CB has been shown to interact with TLX1,{{cite journal | vauthors = Kawabe T, Muslin AJ, Korsmeyer SJ | title = HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint | journal = Nature | volume = 385 | issue = 6615 | pages = 454–8 | date = Jan 1997 | pmid = 9009195 | doi = 10.1038/385454a0 | bibcode = 1997Natur.385..454K | s2cid = 608633 }} PPP2R1B{{cite journal | vauthors = Zhou J, Pham HT, Ruediger R, Walter G | title = Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution | journal = The Biochemical Journal | volume = 369 | issue = Pt 2 | pages = 387–98 | date = Jan 2003 | pmid = 12370081 | pmc = 1223084 | doi = 10.1042/BJ20021244 }} and PPP2R1A.{{cite journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Molecular & Cellular Proteomics | volume = 8 | issue = 1 | pages = 157–71 | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 | doi-access = free }}

• PPP2CA

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• {{cite journal | vauthors = Zolnierowicz S | title = Type 2A protein phosphatase, the complex regulator of numerous signaling pathways | journal = Biochemical Pharmacology | volume = 60 | issue = 8 | pages = 1225–35 | date = Oct 2000 | pmid = 11007961 | doi = 10.1016/S0006-2952(00)00424-X }}
• {{cite journal | vauthors = Goedert M, Cohen ES, Jakes R, Cohen P | title = p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected] | journal = FEBS Letters | volume = 312 | issue = 1 | pages = 95–9 | date = Nov 1992 | pmid = 1330687 | doi = 10.1016/0014-5793(92)81418-L | s2cid = 34940651 | doi-access = free }}
• {{cite journal | vauthors = Khew-Goodall Y, Mayer RE, Maurer F, Stone SR, Hemmings BA | title = Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes | journal = Biochemistry | volume = 30 | issue = 1 | pages = 89–97 | date = Jan 1991 | pmid = 1846293 | doi = 10.1021/bi00215a014 }}
• {{cite journal | vauthors = Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM | title = Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A | journal = Cell | volume = 60 | issue = 1 | pages = 167–76 | date = Jan 1990 | pmid = 2153055 | doi = 10.1016/0092-8674(90)90726-U | s2cid = 2007706 }}
• {{cite journal | vauthors = Virshup DM, Kauffman MG, Kelly TJ | title = Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A | journal = The EMBO Journal | volume = 8 | issue = 12 | pages = 3891–8 | date = Dec 1989 | pmid = 2555176 | pmc = 402079 | doi = 10.1002/j.1460-2075.1989.tb08568.x}}
• {{cite journal | vauthors = Arino J, Woon CW, Brautigan DL, Miller TB, Johnson GL | title = Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 12 | pages = 4252–6 | date = Jun 1988 | pmid = 2837763 | pmc = 280405 | doi = 10.1073/pnas.85.12.4252 | bibcode = 1988PNAS...85.4252A | doi-access = free }}
• {{cite journal | vauthors = Hemmings BA, Wernet W, Mayer R, Maurer F, Hofsteenge J, Stone SR | title = The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit | journal = Nucleic Acids Research | volume = 16 | issue = 23 | pages = 11366 | date = Dec 1988 | pmid = 2849765 | pmc = 339017 | doi = 10.1093/nar/16.23.11366 }}
• {{cite journal | vauthors = Favre B, Zolnierowicz S, Turowski P, Hemmings BA | title = The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo | journal = The Journal of Biological Chemistry | volume = 269 | issue = 23 | pages = 16311–7 | date = Jun 1994 | doi = 10.1016/S0021-9258(17)34009-7 | pmid = 8206937 | doi-access = free }}
• {{cite journal | vauthors = Keranen LM, Dutil EM, Newton AC | title = Protein kinase C is regulated in vivo by three functionally distinct phosphorylations | journal = Current Biology | volume = 5 | issue = 12 | pages = 1394–1403 | date = Dec 1995 | pmid = 8749392 | doi = 10.1016/S0960-9822(95)00277-6 | s2cid = 15610228 | doi-access = free | bibcode = 1995CBio....5.1394K }}
• {{cite journal | vauthors = Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R | title = Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr | journal = FEBS Letters | volume = 401 | issue = 2–3 | pages = 197–201 | date = Jan 1997 | pmid = 9013886 | doi = 10.1016/S0014-5793(96)01470-6 | s2cid = 23293768 | doi-access = free }}
• {{cite journal | vauthors = Nagase T, Murakami T, Nozaki H, Inoue R, Nishito Y, Tanabe O, Usui H, Takeda M | title = Tissue and subcellular distributions, and characterization of rat brain protein phosphatase 2A containing a 72-kDa delta/B" subunit | journal = Journal of Biochemistry | volume = 122 | issue = 1 | pages = 178–87 | date = Jul 1997 | pmid = 9276686 | doi = 10.1093/oxfordjournals.jbchem.a021726 }}
• {{cite journal | vauthors = Ruediger R, Brewis N, Ohst K, Walter G | title = Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production | journal = Virology | volume = 238 | issue = 2 | pages = 432–43 | date = Nov 1997 | pmid = 9400615 | doi = 10.1006/viro.1997.8873 | doi-access = free }}
• {{cite journal | vauthors = Hsu W, Zeng L, Costantini F | title = Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain | journal = The Journal of Biological Chemistry | volume = 274 | issue = 6 | pages = 3439–45 | date = Feb 1999 | pmid = 9920888 | doi = 10.1074/jbc.274.6.3439 | doi-access = free }}
• {{cite journal | vauthors = Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC | title = A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A | journal = The Journal of Biological Chemistry | volume = 274 | issue = 20 | pages = 14382–91 | date = May 1999 | pmid = 10318862 | pmc = 3503312 | doi = 10.1074/jbc.274.20.14382 | doi-access = free }}
• {{cite journal | vauthors = De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J | title = Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue | journal = Biochemistry | volume = 38 | issue = 50 | pages = 16539–47 | date = Dec 1999 | pmid = 10600115 | doi = 10.1021/bi991646a }}
• {{cite journal | vauthors = Götz J, Probst A, Mistl C, Nitsch RM, Ehler E | title = Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development | journal = Mechanisms of Development | volume = 93 | issue = 1–2 | pages = 83–93 | date = May 2000 | pmid = 10781942 | doi = 10.1016/S0925-4773(00)00267-7 | s2cid = 496289 | doi-access = free }}
• {{cite journal | vauthors = Lüss H, Klein-Wiele O, Bokník P, Herzig S, Knapp J, Linck B, Müller FU, Scheld HH, Schmid C, Schmitz W, Neumann J | title = Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart | journal = Journal of Molecular and Cellular Cardiology | volume = 32 | issue = 12 | pages = 2349–59 | date = Dec 2000 | pmid = 11113010 | doi = 10.1006/jmcc.2000.1265 }}

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