Plantar wart

Their colors are typically similar to that of the nearby skin. Small, black dots may occur on their surfaces. One or more may occur in an area. They may result in pain with pressure such that walking may be difficult.

Veruca right foot detail.jpg|A plantar wart: striae (fingerprints) go around the lesion.

File:Plantarwartscluster.jpg|Mosaic wart cluster

File:Wart-IMG 1676.JPG|Young plantar warts

File:30 year old plantar wart.jpg|30-year-old plantar wart

File:Painful plantar warts.jpg|Deep, painful plantar warts

File:Plantar wart at heel.jpg|Deep plantar wart on heel

Plantar warts are benign epithelial tumors generally caused by infection by human papillomavirus types 1, 2, 4, 60, or 63,{{EMedicine|MED|1037|Human Papillomavirus}} but also by types 57,{{cite journal |vauthors=Egawa K, Kitasato H, Honda Y, Kawai S, Mizushima Y, Ono T | title = Human papillomavirus 57 identified in a plantar epidermoid cyst | journal = Br. J. Dermatol. | volume = 138 | issue = 3 | pages = 510–4 | year = 1998 | pmid = 9580810 | doi = 10.1046/j.1365-2133.1998.02135.x | s2cid = 19998825 }} 65,{{cite web |url=http://pave.niaid.nih.gov/lanl-archives/compendium/94PDF/1/sm1g.pdf |title=Human Papillomaviruses Compendium |access-date=2013-02-05 |publisher=Los Alamos National Laboratory }} 66,{{cite journal |vauthors=Davis MD, Gostout BS, McGovern RM, Persing DH, Schut RL, Pittelkow MR | title = Large plantar wart caused by human papillomavirus-66 and resolution by topical cidofovir therapy | journal = J. Am. Acad. Dermatol. | volume = 43 | issue = 2 Pt 2 | pages = 340–3 | year = 2000 | pmid = 10901717 | doi = 10.1067/mjd.2000.100534 }} and 156.{{cite journal |vauthors=Chouhy D, Bolatti EM, Piccirilli G, Sánchez A, Fernandez Bussy R, Giri AA | title = Identification of human papillomavirus type 156, the prototype of a new human gammapapillomavirus species, by a generic and highly sensitive PCR strategy for long DNA fragments | journal = J. Gen. Virol. | volume = 94 | issue = Pt 3 | pages = 524–33 | year = 2013 | pmid = 23136368 | doi = 10.1099/vir.0.048157-0 | doi-access = free | hdl = 11336/4852 | hdl-access = free }} These types are classified as clinical (visible symptoms). The virus attacks compromised skin through direct contact, possibly entering through tiny cuts and abrasions in the stratum corneum (outermost layer of skin). After infection, warts may not become visible for several weeks or months. Because of pressure on the sole of the foot or finger, the wart is pushed inward and a layer of hard skin may form over the wart. A plantar wart can be painful if left untreated.{{EMedicine|EMERG|641|Warts, Plantar}}

Warts may spread through autoinoculation, by infecting nearby skin, or by contaminated walking surfaces. They may fuse or develop into clusters called mosaic warts.

A plantar wart is a small lesion that appears on the surface of the skin and typically resembles a cauliflower, with tiny black petechiae (tiny hemorrhages under the skin) in the center. Pinpoint bleeding may occur when these are scratched. Plantar warts occur on the soles of feet and toes. They may be painful when standing or walking.{{cn|date=May 2021}}

Plantar warts are often similar to calluses or corns, but can be differentiated by close observation of skin striations. Feet are covered in friction ridges, which are akin to fingerprints of the feet. Friction ridges are disrupted by plantar warts; if the lesion is not a plantar wart, the striations continue across the top layer of the skin. Plantar warts tend to be painful on application of pressure from either side of the lesion rather than direct pressure, unlike corns (which tend to be painful on direct pressure, instead).{{cn|date=May 2021}}

HPV is spread by direct and indirect contact from an infected host. Avoiding direct contact with contaminated surfaces such as communal changing rooms and shower floors and benches, avoiding sharing of shoes and socks and avoiding contact with warts on other parts of the body and on the bodies of others may help reduce the spread of infection. Infection is less common among adults than children.{{cite web |url=http://www.hipusa.com/webmd/encyclopedia/plantar_warts/index.html |title=Understanding Plantar Warts |access-date=2007-12-07 |publisher=Health Plan of New York }}

As all warts are contagious, precautions should be taken to avoid spreading them. Recommendations include:

• Cover them with an adhesive bandage while swimming
• Wear latex swimming socks
• Wear flip-flops when using communal showers
• Do not share towels.{{cite web |title=Clinical Knowledge Summaries: Previous version – Warts (including verrucas) |url=http://www.cks.nhs.uk/clinical_knowledge/clinical_topics/previous_version/warts_and_verrucae.pdf |publisher=National Health Service |access-date=2010-12-05 |page=2 |date=January 2007 |url-status=dead |archive-url=https://web.archive.org/web/20110601150216/http://www.cks.nhs.uk/clinical_knowledge/clinical_topics/previous_version/warts_and_verrucae.pdf |archive-date=2011-06-01 }}

Plantar warts are not prevented by inoculation with HPV vaccines because the warts are caused by different strains of HPV. Gardasil protects against strains 6, 11, 16, and 18, and Cervarix protects against 16 and 18, whereas plantar warts are caused by strains 1, 2, 4, and 63.{{dubious|date=September 2020}}

{{further|Wart#Treatment}}

Image:Wart cryotherapy.jpg]]

A number of treatments have been found to be effective.{{cite journal |vauthors=Bacelieri R, Johnson SM |title = Cutaneous warts: an evidence-based approach to therapy |journal = Am Fam Physician |volume = 72 |issue = 4 |pages = 647–52 |year = 2005 |pmid = 16127954 |url = http://www.aafp.org/afp/20050815/647.html}} A 2012 review of different treatments for skin warts in otherwise healthy people concluded modest benefit from salicylic acid, and cryotherapy appears similar to salicylic acid.{{cite journal |last1=Kwok |first1=Chun Shing |last2=Gibbs |first2=Sam |last3=Bennett |first3=Cathy |last4=Holland |first4=Richard |last5=Abbott |first5=Rachel |title=Topical treatments for cutaneous warts |journal=Cochrane Database of Systematic Reviews |date=12 September 2012 |volume=2020 |issue=9 |pages=CD001781 |doi=10.1002/14651858.CD001781.pub3 |pmid=22972052 |pmc=8101088 }}

Salicylic acid, the treatment of warts by keratolysis, involves the peeling away of dead surface skin cells with keratolytic chemicals such as salicylic acid or trichloroacetic acid. These are available in over-the-counter products, but in higher concentrations may need to be prescribed by a physician. A 12-week daily treatment with salicylic acid has been shown to lead to a complete clearance of warts in 10–15% of the cases.{{cite journal |last1=Cockayne |first1=S |last2=Curran |first2=M |last3=Denby |first3=G |last4=Hashmi |first4=F |last5=Hewitt |first5=C |last6=Hicks |first6=K |last7=Jayakody |first7=S |last8=Kang’ombe |first8=A |last9=McIntosh |first9=C |last10=McLarnon |first10=N |last11=Stamuli |first11=E |last12=Thomas |first12=K |last13=Turner |first13=G |last14=Torgerson |first14=D |last15=Watt |first15=I |author16=EVerT team |title=EVerT: cryotherapy versus salicylic acid for the treatment of verrucae – a randomised controlled trial |journal=Health Technology Assessment |date=September 2011 |volume=15 |issue=32 |pages=1–170 |doi=10.3310/hta15320 |pmid=21899812 |doi-access=free }}

Formic acid, topical, is a common treatment for plantar warts, which works by being applied over a period of time, causing the body to reject the wart.{{cite journal |last1=Bhat |first1=RM |last2=Vidya |first2=K |last3=Kamath |first3=G |title=Topical formic acid puncture technique for the treatment of common warts |journal=International Journal of Dermatology |date=June 2001 |volume=40 |issue=6 |pages=415–9 |pmid=11589750 |doi=10.1046/j.1365-4362.2001.01242.x |s2cid=42351889 }}

Fluorouracil cream, a chemotherapy agent sometimes used to treat skin cancer, can be used on particularly resistant warts, by blocking viral DNA and RNA production and repair.

Bleomycin, a more potent chemotherapy drug, can be injected into deep warts, destroying the viral DNA or RNA. Bleomycin is notably not US FDA approved for this purpose. Possible side effects include necrosis of the digits, nail loss, and Raynaud syndrome. The usual treatment is one or two injections.{{cite journal |last1=Soni |first1=Prasoon |last2=Khandelwal |first2=Kanika |last3=Aara |first3=Naushin |last4=Ghiya |first4=Bhikam C |last5=Mehta |first5=Rajesh D |last6=Bumb |first6=Ram A |title=Efficacy of Intralesional Bleomycin in Palmo-plantar and Periungual Warts |journal=Journal of Cutaneous and Aesthetic Surgery |date=2011 |volume=4 |issue=3 |pages=188–191 |doi=10.4103/0974-2077.91250 |pmid=22279384 |pmc=3263129 |doi-access=free }}Champion, R. H., et al. (1998). Rook's Textbook of Dermatology. Blackwell Science, p. 1044, {{ISBN|0-632-06429-3}}

Immunotherapy, as intralesional injection of antigens (mumps, candida or trichophytin antigens USP), is a wart treatment that may trigger a host immune response to the wart virus, resulting in wart resolution. It is now recommended as a second-line therapy.{{cite journal |vauthors=Bacelieri R, Johnson SM |title = Cutaneous warts: An evidence-based approach to therapy |journal = American Family Physician |volume = 72 |issue = 4 |pages = 647–652 |year = 2005 |pmid = 16127954 |url = http://www.aafp.org/afp/2005/0815/p647.html }}

File:Plantar wart papilloma.jpg

Liquid nitrogen and similar cryosurgery methods are common surgical treatments, which act by freezing the external cell structure of the warts, destroying the live tissue.{{cn|date=May 2021}}

Electrodesiccation and surgical excision may produce scarring.{{cn|date=May 2021}}

Laser surgery is generally a last resort treatment, as it is expensive and painful, but may be necessary for large, hard-to-cure warts.[http://www.webmd.com/skin-problems-and-treatments/laser-surgery-for-warts "Laser Surgery for Warts"], webmd.com

Cauterization may be effective as a prolonged treatment. As a short-term treatment, cauterization of the base with anesthetic can be effective, but this method risks scarring or keloids. Subsequent surgical removal, if necessary, also risks keloids and/or recurrence in the operative scar.{{cite book |title=Evidence-based Medicine Guidelines |last=Kunnamo |first=Ilkka |year=2005 |publisher=John Wiley and Sons |isbn=978-0-470-01184-3 |pages=422 |url=https://books.google.com/books?id=frYEiHYtOv0C&pg=PA422 }}

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{{Reflist}}

{{Medical resources

| ICD10 = B07

| ICD9 = {{ICD9|078.12}}

}}

• [http://www.mayoclinic.com/health/plantar-warts/DS00509 Plantar warts] at the Mayo Clinic website
• [https://www.merckmanuals.com/home/skin-disorders/viral-skin-infections/warts?query=Warts Warts] at Merck Manual

{{Viral cutaneous conditions}}

{{Human papillomavirus}}

{{DEFAULTSORT:Plantar Wart}}

Category:Virus-related cutaneous conditions

Category:Foot diseases

Category:Papillomavirus-associated diseases

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