RABEP1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the RABEP1 gene.{{cite journal | vauthors = Stenmark H, Vitale G, Ullrich O, Zerial M | title = Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion | journal = Cell | volume = 83 | issue = 3 | pages = 423–32 | date = Nov 1995 | pmid = 8521472 | doi = 10.1016/0092-8674(95)90120-5 | doi-access = free }}{{cite web | title = Entrez Gene: RABEP1 rabaptin, RAB GTPase binding effector protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9135}} It belongs to rabaptin protein family.

Interactions

RABEP1 has been shown to interact with:

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  • AP1G1,{{cite journal | vauthors = Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S | title = Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain | journal = Nature Structural Biology | volume = 9 | issue = 7 | pages = 527–31 | date = Jul 2002 | pmid = 12042876 | doi = 10.1038/nsb808 | s2cid = 42630285 }}
  • GGA1,
  • GGA2,{{cite journal | vauthors = Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS | title = Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex | journal = The EMBO Journal | volume = 22 | issue = 1 | pages = 78–88 | date = Jan 2003 | pmid = 12505986 | pmc = 140067 | doi = 10.1093/emboj/cdg015 }}
  • RAB4A,{{cite journal | vauthors = Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M | title = Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5 | journal = The EMBO Journal | volume = 17 | issue = 7 | pages = 1941–51 | date = Apr 1998 | pmid = 9524117 | pmc = 1170540 | doi = 10.1093/emboj/17.7.1941 }} and
  • RAB5A.{{cite journal | vauthors = Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS | title = The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis | journal = The Journal of Biological Chemistry | volume = 272 | issue = 10 | pages = 6097–100 | date = Mar 1997 | pmid = 9045618 | doi = 10.1074/jbc.272.10.6097| doi-access = free | hdl = 20.500.12613/9244 | hdl-access = free }}{{cite journal | vauthors = Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T | title = Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER | journal = FEBS Letters | volume = 508 | issue = 2 | pages = 201–9 | date = Nov 2001 | pmid = 11718716 | doi = 10.1016/s0014-5793(01)02993-3| s2cid = 21545088 | doi-access = free }}

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References

{{Reflist}}

Further reading

{{Refbegin | 2}}

  • {{cite journal | vauthors = Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS | title = The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis | journal = The Journal of Biological Chemistry | volume = 272 | issue = 10 | pages = 6097–100 | date = Mar 1997 | pmid = 9045618 | doi = 10.1074/jbc.272.10.6097 | doi-access = free | hdl = 20.500.12613/9244 | hdl-access = free }}
  • {{cite journal | vauthors = Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M | title = Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5 | journal = The EMBO Journal | volume = 17 | issue = 7 | pages = 1941–51 | date = Apr 1998 | pmid = 9524117 | pmc = 1170540 | doi = 10.1093/emboj/17.7.1941 }}
  • {{cite journal | vauthors = Neve RL, Coopersmith R, McPhie DL, Santeufemio C, Pratt KG, Murphy CJ, Lynn SD | title = The neuronal growth-associated protein GAP-43 interacts with rabaptin-5 and participates in endocytosis | journal = The Journal of Neuroscience | volume = 18 | issue = 19 | pages = 7757–67 | date = Oct 1998 | pmid = 9742146 | pmc = 6793001 | doi = 10.1523/JNEUROSCI.18-19-07757.1998| doi-access = free }}
  • {{cite journal | vauthors = Swanton E, Bishop N, Woodman P | title = Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis | journal = The Journal of Biological Chemistry | volume = 274 | issue = 53 | pages = 37583–90 | date = Dec 1999 | pmid = 10608812 | doi = 10.1074/jbc.274.53.37583 | doi-access = free }}
  • {{cite journal | vauthors = Nagelkerken B, Van Anken E, Van Raak M, Gerez L, Mohrmann K, Van Uden N, Holthuizen J, Pelkmans L, Van Der Sluijs P | title = Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles | journal = The Biochemical Journal | volume = 346 | issue = 3 | pages = 593–601 | date = Mar 2000 | pmid = 10698684 | pmc = 1220890 | doi = 10.1042/0264-6021:3460593 }}
  • {{cite journal | vauthors = Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS | title = A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome | journal = The Journal of Cell Biology | volume = 149 | issue = 1 | pages = 67–80 | date = Apr 2000 | pmid = 10747088 | pmc = 2175106 | doi = 10.1083/jcb.149.1.67 }}
  • {{cite journal | vauthors = Korobko IV, Korobko EV, Kiselev SL | title = The MAK-V protein kinase regulates endocytosis in mouse | journal = Molecular & General Genetics | volume = 264 | issue = 4 | pages = 411–8 | date = Nov 2000 | pmid = 11129044 | doi = 10.1007/s004380000293 | s2cid = 21231710 }}
  • {{cite journal | vauthors = Zhu Y, Doray B, Poussu A, Lehto VP, Kornfeld S | title = Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor | journal = Science | volume = 292 | issue = 5522 | pages = 1716–8 | date = Jun 2001 | pmid = 11387476 | doi = 10.1126/science.1060896 | bibcode = 2001Sci...292.1716Z | s2cid = 9453730 }}
  • {{cite journal | vauthors = Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T | title = Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER | journal = FEBS Letters | volume = 508 | issue = 2 | pages = 201–9 | date = Nov 2001 | pmid = 11718716 | doi = 10.1016/S0014-5793(01)02993-3 | s2cid = 21545088 | doi-access = free }}
  • {{cite journal | vauthors = de Renzis S, Sönnichsen B, Zerial M | title = Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes | journal = Nature Cell Biology | volume = 4 | issue = 2 | pages = 124–33 | date = Feb 2002 | pmid = 11788822 | doi = 10.1038/ncb744 | s2cid = 6596498 }}
  • {{cite journal | vauthors = Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS | title = Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex | journal = The EMBO Journal | volume = 22 | issue = 1 | pages = 78–88 | date = Jan 2003 | pmid = 12505986 | pmc = 140067 | doi = 10.1093/emboj/cdg015 }}
  • {{cite journal | vauthors = Mattera R, Puertollano R, Smith WJ, Bonifacino JS | title = The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites | journal = The Journal of Biological Chemistry | volume = 279 | issue = 30 | pages = 31409–18 | date = Jul 2004 | pmid = 15143060 | doi = 10.1074/jbc.M402183200 | doi-access = free }}
  • {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = Aug 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 | doi-access = free | bibcode = 2004CBio...14.1436J }}
  • {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
  • {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}

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{{PDB Gallery|geneid=9135}}

{{Gene-17-stub}}