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RCAN3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

RCAN3 is a gene that in humans encodes the Calcipressin-3 protein.

File:PDB 1wey EBI.jpg

Calcipressin-3 is a protein that in humans is encoded by the RCAN3 gene and is a member of the Calcipressin family of proteins.{{cite journal | vauthors = Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M | title = A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2) | journal = Genomics | volume = 64 | issue = 3 | pages = 252–63 |date=May 2000 | pmid = 10756093 | doi = 10.1006/geno.2000.6127 }}{{cite web | title = Entrez Gene: DSCR1L2 Down syndrome critical region gene 1-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11123}}

Expression

RCAN3 is highly expressed in the Cerebellar Hemisphere, Prostrate, and the Mucosa of the esophagus.{{Cite web|title=Gene Expression in 53 tissues from GTEx RNA-seq of 8555 samples (570 donors) (RCAN3)|url=https://genome.ucsc.edu/cgi-bin/hgc?hgsid=844015689_QInaYNiyMoaPWGAgiraQV5YwF3sH&c=chr1&l=24502835&r=24541040&o=24502896&t=24533254&g=gtexGene&i=RCAN3|access-date=2020-06-11|website=genome.ucsc.edu}}


Orthologs

RCAN3 was present in the common ancestor of all animals. As a result, orthologs are present in other species, including mice (Rcan3), chickens (RCAN3), and zebrafish (rcan3).{{Cite web|title=RCAN3 Gene - GeneCards {{!}} RCAN3 Protein {{!}} RCAN3 Antibody|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=RCAN3#orthologs|access-date=2020-06-11|website=www.genecards.org}}

Clinical Significance

Calcipressin-3, along with the other two Calcipressin proteins have been identified as possible contributing factors to Down Syndrome in humans.{{Cite web|title=InterPro|url=https://www.ebi.ac.uk/interpro/entry/InterPro/IPR034923/|access-date=2020-06-11|website=www.ebi.ac.uk}}

Summary box

N/A

See also

References

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Further reading

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  • {{cite journal |vauthors=Facchin F, Canaider S, Vitale L, etal |title=Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms. |journal=Gene |volume=407 |issue= 1–2 |pages= 159–68 |year= 2008 |pmid= 18022329 |doi= 10.1016/j.gene.2007.10.006 }}
  • {{cite journal | vauthors=Mulero MC, Aubareda A, Schlüter A, Pérez-Riba M |title=RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression. |journal=Biochim. Biophys. Acta |volume=1773 |issue= 3 |pages= 330–41 |year= 2007 |pmid= 17270291 |doi= 10.1016/j.bbamcr.2006.12.007 |doi-access= free }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
  • {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}
  • {{cite journal |vauthors=Canaider S, Facchin F, Griffoni C, etal |title=Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3). |journal=Gene |volume=372 |pages= 128–36 |year= 2006 |pmid= 16516408 |doi= 10.1016/j.gene.2005.12.029 |hdl=11586/196835 |hdl-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}

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