RTI-32

{{Short description|Chemical compound}}

{{Drugbox

| verifiedrevid = 401640840

| IUPAC_name = Methyl (1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate

| image = Phenyltropane 11f.svg

| tradename =

| CAS_number = 130342-81-3

| ATC_prefix =

| ATC_suffix =

| PubChem = 125416

| ChemSpiderID = 111596

| ChEMBL = 1947089

| C=17 | H=23 | N=1 | O=2

| smiles = CC1=CC=C(C=C1)[C@H]2C[C@@H]3CC[C@H]([C@H]2C(=O)OC)N3C

| StdInChI = 1S/C17H23NO2/c1-11-4-6-12(7-5-11)14-10-13-8-9-15(18(13)2)16(14)17(19)20-3/h4-7,13-16H,8-10H2,1-3H3/t13-,14+,15+,16-/m0/s1

| StdInChIKey = MMKZDDDDODERSJ-JJXSEGSLSA-N

}}

(–)-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-4229-32, tolpane) is a phenyltropane-based cocaine analogue that has similar properties in vitro to related drugs such as RTI-31.{{cite journal | vauthors = Remy P, Doder M, Lees A, Turjanski N, Brooks D | title = Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system | journal = Brain | volume = 128 | issue = Pt 6 | pages = 1314–22 | date = June 2005 | pmid = 15716302 | doi = 10.1093/brain/awh445 | doi-access = free }}{{cite journal | vauthors = Xu L, Izenwasser S, Katz JL, Kopajtic T, Klein-Stevens C, Zhu N, Lomenzo SA, Winfield L, Trudell ML | display-authors = 6 | title = Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters | journal = Journal of Medicinal Chemistry | volume = 45 | issue = 6 | pages = 1203–10 | date = March 2002 | pmid = 11881989 | doi = 10.1021/jm010453u }}

| Compound

Comparison of Data

class="wikitable"
DAT	DA	NET	NA	SERT	5HT	ED50
Troparil	23	49.8	550	37.2	178	173	0.34
RTI-32	1.7	7.02	36	8.42	23	19.4	0.31
RTI-31	1.1	3.68	22	5.86	4.0	5.0	0.13
3'4'-xylyl	0.43	unknown	44	unknown	2.42	unknown