Rickettsia#Spotted fever group

The classification of Rickettsia into three groups (spotted fever, typhus, and scrub typhus) was initially based on serology. This grouping has since been confirmed by DNA sequencing. All three of these groups include human pathogens. The scrub typhus group has been reclassified as a related new genus, Orientia, but they still are in the order Rickettsiales and accordingly still are grouped with the rest of the rickettsial diseases.{{citation needed|date=April 2022}}

Rickettsias are more widespread than previously believed and are known to be associated with arthropods, leeches, and protists. Divisions have also been identified in the spotted fever group and this group should probably be divided into two clades.{{cite journal | vauthors = Gillespie JJ, Beier MS, Rahman MS, Ammerman NC, Shallom JM, Purkayastha A, Sobral BS, Azad AF | display-authors = 6 | title = Plasmids and rickettsial evolution: insight from Rickettsia felis | journal = PLOS ONE | volume = 2 | issue = 3 | pages = e266 | date = March 2007 | pmid = 17342200 | pmc = 1800911 | doi = 10.1371/journal.pone.0000266 | bibcode = 2007PLoSO...2..266G | doi-access = free }} {{open access}}. Arthropod-inhabiting rickettsiae are generally associated with reproductive manipulation (such as parthenogenesis) to persist in host lineage.

In March 2010, Swedish researchers reported a case of bacterial meningitis in a woman caused by Rickettsia helvetica previously thought to be harmless.[https://www.cdc.gov/eid/content/16/3/490.htm "Rickettsia helvetica in Patient with Meningitis, Sweden, 2006" Emerging Infectious Diseases, Volume 16, Number 3 – March 2010]

:* Rickettsia rickettsii (Western Hemisphere)

:: Rocky Mountain spotted fever

:* Rickettsia akari (USA, former Soviet Union)

:: Rickettsialpox

:* Rickettsia conorii (Mediterranean countries, Africa, Southwest Asia, India)

:: Boutonneuse fever

:* Rickettsia sibirica (Siberia, Mongolia, northern China)

:: Siberian tick typhus or North Asian tick typhus

:* Rickettsia australis (Australia)

:: Australian tick typhus

:* Rickettsia felis (North and South America, Southern Europe, Australia)

:: Flea-borne spotted fever

:* Rickettsia japonica (Japan)

:: Oriental spotted fever

:* Rickettsia africae (South Africa)

:: African tick bite fever

:* Rickettsia hoogstraalii (Croatia, Spain and Georgia USA)Duh, D., V. Punda-Polic, T. Avsic-Zupanc, D. Bouyer, D.H. Walker, V.L. Popov, M. Jelovsek, M. Gracner, T. Trilar, N. Bradaric, T.J. Kurtti and J. Strus. (2010) Rickettsia hoogstraalii sp. nov., isolated from hard- and soft-bodied ticks. International Journal of Systematic and Evolutionary Microbiology, 60, 977–984; [https://archive.today/20120710185809/http://ijs.sgmjournals.org/cgi/content/abstract/60/4/977], accessed 16 July 2010.

:: Unknown pathogenicity

:* Rickettsia prowazekii (worldwide)

:: Epidemic typhus, recrudescent typhus, and sporadic typhus

:* Rickettsia typhi (worldwide)

:: Murine typhus (endemic typhus)

:* The causative agent of scrub typhus formerly known as R. tsutsugamushi has been reclassified into the genus Orientia.{{Rickettsialesphylogeny}}

Plant diseases have been associated with these Rickettsia-like organisms (RLOs):{{Cite book|vauthors=Smith IM, Dunez J, Lelliot RA, Phillips DH, Archer SA | title = European Handbook of Plant Diseases. | publisher = Blackwell Scientific Publications| year = 1988 | isbn = 978-0-632-01222-0}}

:* Beet latent rosette RLO

:* Citrus greening bacterium possibly this citrus greening disease

:* Clover leaf RLO

:* Grapevine infectious necrosis RLO

:* Grapevine Pierce's RLO

:* Grapevine yellows RLO

:* Witch's broom disease on Larix spp.

:* Peach phony RLO

:* Papaya Bunchy Top Disease[https://www.apsnet.org/publications/phytopathology/backissues/Documents/1996Abstracts/Phyto_86_102.htm Davis, M. J. 1996]

Infection occurs in nonhuman mammals; for example, species of Rickettsia have been found to afflict the South American guanaco, Lama guanacoeC. Michael Hogan. 2008. [http://globaltwitcher.auderis.se/artspec_information.asp?thingid=42654 Guanaco: Lama guanicoe, GlobalTwitcher.com, ed. N. Strömberg] {{webarchive |url=https://web.archive.org/web/20110304004355/http://globaltwitcher.auderis.se/artspec_information.asp?thingid=42654 |date=4 March 2011 }} potentially marsupialsVilcins IE, Old JM, Deane EM (2009). Molecular detection of Rickettsia, Coxiella and Rickettsiella in three Australian native tick species. Experimental and Applied Acarology. 49(3), 229-242. DOI: 10.1007/s10493-009-9260-4Vilcins IE, Old JM, Deane EM (2008). Detection of a spotted fever group Rickettsia in the tick Ixodes tasmani collected from koalas (Phascolarctos cinereus) in Port Macquarie, N.S.W. Journal of Medical Entomology. 45(4), 745-750. DOI: 10.1016/j.vetpar.2009.02.015 and reptiles.Vilcins I, Fournier P, Old JM, Deane EM (2009). Evidence for the presence of Francisella and spotted fever group Rickettsia DNA in the Tick Amblyomma fimbriatum (Acari: Ixodidae), Northern Territory, Australia. Journal of Medical Entomology. 46(4), 926-933. doi: 10.1186/s13071-015-0719-3

{{expand section|date=August 2013}}

{{main|Typhus}}

Rickettsial organisms are obligate intracellular parasites and invade vascular endothelial cells in target organs, damaging them and producing increased vascular permeability with consequent oedema, hypotension, and hypoalbuminaemia.{{cite web |url= https://reference.medscape.com/article/968385-overview#showall|title= Rickettsial infection: Overview| vauthors = Rathore MH |date= 14 June 2016|website= Medscape|access-date= 16 November 2017}}

Certain segments of rickettsial genomes resemble those of mitochondria.{{cite journal | vauthors = Emelyanov VV | title = Mitochondrial connection to the origin of the eukaryotic cell | journal = European Journal of Biochemistry | volume = 270 | issue = 8 | pages = 1599–1618 | date = April 2003 | pmid = 12694174 | doi = 10.1046/j.1432-1033.2003.03499.x | doi-access = free }} The deciphered genome of R. prowazekii is 1,111,523 bp long and contains 834 genes.{{cite journal | vauthors = Andersson SG, Zomorodipour A, Andersson JO, Sicheritz-Pontén T, Alsmark UC, Podowski RM, Näslund AK, Eriksson AS, Winkler HH, Kurland CG | display-authors = 6 | title = The genome sequence of Rickettsia prowazekii and the origin of mitochondria | journal = Nature | volume = 396 | issue = 6707 | pages = 133–140 | date = November 1998 | pmid = 9823893 | doi = 10.1038/24094 | doi-access = free | bibcode = 1998Natur.396..133A | author1-link = Siv G. E. Andersson }} Unlike free-living bacteria, it contains no genes for anaerobic glycolysis or genes involved in the biosynthesis and regulation of amino acids and nucleosides. In this regard, it is similar to mitochondrial genomes; in both cases, nuclear (host) resources are used.

ATP production in Rickettsia is the same as that in mitochondria. In fact, of all the microbes known, the Rickettsia is probably the closest relative (in a phylogenetic sense) to the mitochondria. Unlike the latter, the genome of R. prowazekii, however, contains a complete set of genes encoding for the tricarboxylic acid cycle and the respiratory chain complex. Still, the genomes of the Rickettsia, as well as the mitochondria, are frequently said to be "small, highly derived products of several types of reductive evolution".

The recent discovery of another parallel between Rickettsia and viruses may become a basis for fighting HIV infection.{{cite journal | vauthors = Kannangara S, DeSimone JA, Pomerantz RJ | title = Attenuation of HIV-1 infection by other microbial agents | journal = The Journal of Infectious Diseases | volume = 192 | issue = 6 | pages = 1003–1009 | date = September 2005 | pmid = 16107952 | doi = 10.1086/432767 | doi-access = free }} Human immune response to the scrub typhus pathogen, Orientia tsutsugamushi, appears to provide a beneficial effect against HIV infection progress, negatively influencing the virus replication process. A probable reason for this actively studied phenomenon is a certain degree of homology between the rickettsiae and the virus, namely, common epitope(s) due to common genome fragment(s) in both pathogens. Surprisingly, the other infection reported to be likely to provide the same effect (decrease in viral load) is the virus-caused illness dengue fever.

Comparative analysis of genomic sequences have also identified five conserved signature indels in important proteins, which are uniquely found in members of the genus Rickettsia. These indels consist of a four-amino-acid insertion in transcription repair coupling factor Mfd, a 10-amino-acid insertion in ribosomal protein L19, a one-amino-acid insertion in FtsZ, a one-amino-acid insertion in major sigma factor 70, and a one-amino-acid deletion in exonuclease VII. These indels are all characteristic of the genus and serve as molecular markers for Rickettsia.{{cite journal | vauthors = Gupta RS | title = Protein signatures distinctive of alpha proteobacteria and its subgroups and a model for alpha-proteobacterial evolution | journal = Critical Reviews in Microbiology | volume = 31 | issue = 2 | pages = 101–135 | date = January 2005 | pmid = 15986834 | doi = 10.1080/10408410590922393 | s2cid = 30170035 }}

Bacterial small RNAs play critical roles in virulence and stress/adaptation responses. Although their specific functions have not been discovered in Rickettsia, few studies showed the expression of novel sRNA in human microvascular endothelial cells (HMEC) infected with Rickettsia.{{cite journal | vauthors = Schroeder CL, Narra HP, Rojas M, Sahni A, Patel J, Khanipov K, Wood TG, Fofanov Y, Sahni SK | display-authors = 6 | title = Bacterial small RNAs in the Genus Rickettsia | journal = BMC Genomics | volume = 16 | pages = 1075 | date = December 2015 | pmid = 26679185 | pmc = 4683814 | doi = 10.1186/s12864-015-2293-7 | doi-access = free }}{{cite journal | vauthors = Schroeder CL, Narra HP, Sahni A, Rojas M, Khanipov K, Patel J, Shah R, Fofanov Y, Sahni SK | display-authors = 6 | title = Identification and Characterization of Novel Small RNAs in Rickettsia prowazekii | journal = Frontiers in Microbiology | volume = 7 | pages = 859 | date = 2016 | pmid = 27375581 | pmc = 4896933 | doi = 10.3389/fmicb.2016.00859 | doi-access = free }}

Genomes of intracellular or parasitic bacteria undergo massive reduction compared to their free-living relatives. Examples include Rickettsia for alpha proteobacteria, T. whipplei for Actinobacteria, Mycoplasma for Firmicutes (the low G+C content Gram-positive), and Wigglesworthia and Buchnera for gamma proteobacteria.{{cite journal | vauthors = Raoult D, Ogata H, Audic S, Robert C, Suhre K, Drancourt M, Claverie JM | title = Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome | journal = Genome Research | volume = 13 | issue = 8 | pages = 1800–1809 | date = August 2003 | pmid = 12902375 | pmc = 403771 | doi = 10.1101/gr.1474603 }}

The genus Rickettsia is named after Howard Taylor Ricketts (1871–1910), who studied Rocky Mountain spotted fever in the Bitterroot Valley of Montana, and eventually died of typhus after studying that disease in Mexico City.

In his early part of career, he undertook research at Northwestern University on blastomycosis. He later worked on Rocky Mountain spotted fever at the University of Chicago and Bitterroot Valley of Montana. He was so devoted to his research that on several occasions, he injected himself with pathogens to study their effects. On account of the apparent similarity between Rocky Mountain fever and typhus fever, he became occupied in investigating the latter in Chicago where the disease was epidemic, and became a victim of the epidemic in 1910. His investigations and discoveries added materially to the sum of medical knowledge.

{{Reflist}}

• [https://patricbrc.org/view/Taxonomy/780#view_tab=overview Rickettsia] genomes and related information at [http://patricbrc.org/ PATRIC], a Bioinformatics Resource Center funded by [http://www.niaid.nih.gov/ NIAID]
• [https://www.cdc.gov/ncidod/EID/vol12no09/05-1540.htm African Tick Bite Fever] from the [https://www.cdc.gov/ncidod/eid/ Centers for Disease Control and Prevention]

{{Taxonbar|from=Q627992}}

{{Authority control}}

Category:Rickettsiaceae

Category:Bacteria genera

Category:Pathogenic bacteria