SCP2

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.{{cite web | title = Entrez Gene: SCP2 sterol carrier protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6342}}

This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis.

SCP2 has been shown to interact with Caveolin 1{{cite journal | vauthors = Zhou M, Parr RD, Petrescu AD, Payne HR, Atshaves BP, Kier AB, Ball JM, Schroeder F | title = Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo | journal = Biochemistry | volume = 43 | issue = 23 | pages = 7288–306 | date = June 2004 | pmid = 15182174 | doi = 10.1021/bi035914n | url = https://scholarworks.sfasu.edu/biology/44 | url-access = subscription }} and peroxisomal receptor PEX5.{{cite journal | vauthors = Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M | title = Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p | journal = Mol. Cell | volume = 24 | issue = 5 | pages = 653–63 | date = December 2006 | pmid = 17157249 | pmc = 5030714 | doi = 10.1016/j.molcel.2006.10.024}}

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• {{cite journal |vauthors=Seedorf U, Ellinghaus P, Roch Nofer J |title=Sterol carrier protein-2 |journal=Biochim. Biophys. Acta |volume=1486 |issue= 1 |pages= 45–54 |year= 2000 |pmid= 10856712 |doi= 10.1016/s1388-1981(00)00047-0}}
• {{cite journal |vauthors=Gallegos AM, Atshaves BP, Storey SM, etal |title=Gene structure, intracellular localization, and functional roles of sterol carrier protein-2 |journal=Prog. Lipid Res. |volume=40 |issue= 6 |pages= 498–563 |year= 2001 |pmid= 11591437 |doi=10.1016/S0163-7827(01)00015-7 }}
• {{cite journal | author=Yamamoto R |title=[Localization of human sterol carrier protein 2 gene and cDNA expression in COS-7 cell] |journal=Hokkaido Igaku Zasshi |volume=67 |issue= 6 |pages= 839–48 |year= 1993 |pmid= 1483685 }}
• {{cite journal |vauthors=Baker ME, Billheimer JT, Strauss JF |title=Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx |journal=DNA Cell Biol. |volume=10 |issue= 9 |pages= 695–8 |year= 1992 |pmid= 1755959 |doi=10.1089/dna.1991.10.695 }}
• {{cite journal |vauthors=Schroeder F, Butko P, Nemecz G, Scallen TJ |title=Interaction of fluorescent delta 5,7,9(11),22-ergostatetraen-3 beta-ol with sterol carrier protein-2 |journal=J. Biol. Chem. |volume=265 |issue= 1 |pages= 151–7 |year= 1990 |doi=10.1016/S0021-9258(19)40208-1 |pmid= 2294101 |doi-access=free }}
• {{cite journal |vauthors=Ohba T, Holt JA, Billheimer JT, Strauss JF |title=Human sterol carrier protein x/sterol carrier protein 2 gene has two promoters |journal=Biochemistry |volume=34 |issue= 33 |pages= 10660–8 |year= 1995 |pmid= 7654720 |doi=10.1021/bi00033a042 }}
• {{cite journal |vauthors=Ohba T, Rennert H, Pfeifer SM, etal |title=The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2) |journal=Genomics |volume=24 |issue= 2 |pages= 370–4 |year= 1995 |pmid= 7698762 |doi= 10.1006/geno.1994.1630 |doi-access= free }}
• {{cite journal |vauthors=Woodford JK, Colles SM, Myers-Payne S, etal |title=Sterol carrier protein-2 stimulates intermembrane sterol transfer by direct membrane interaction |journal=Chem. Phys. Lipids |volume=76 |issue= 1 |pages= 73–84 |year= 1995 |pmid= 7788802 |doi=10.1016/0009-3084(95)02436-M }}
• {{cite journal |vauthors=Vesa J, Hellsten E, Barnoski BL, etal |title=Assignment of sterol carrier protein X/sterol carrier protein 2 to 1p32 and its exclusion as the causative gene for infantile neuronal ceroid lipofuscinosis |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 341–6 |year= 1994 |pmid= 8004106 |doi=10.1093/hmg/3.2.341 }}
• {{cite journal |vauthors=Seedorf U, Brysch P, Engel T, etal |title=Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity |journal=J. Biol. Chem. |volume=269 |issue= 33 |pages= 21277–83 |year= 1994 |doi=10.1016/S0021-9258(17)31960-9 |pmid= 8063752 |doi-access=free }}
• {{cite journal |vauthors=Szyperski T, Scheek S, Johansson J, etal |title=NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2 |journal=FEBS Lett. |volume=335 |issue= 1 |pages= 18–26 |year= 1993 |pmid= 8243660 |doi=10.1016/0014-5793(93)80431-S |s2cid=9969358 |doi-access=free }}
• {{cite journal |vauthors=Seedorf U, Scheek S, Engel T, etal |title=Structure-activity studies of human sterol carrier protein 2 |journal=J. Biol. Chem. |volume=269 |issue= 4 |pages= 2613–8 |year= 1994 |doi=10.1016/S0021-9258(17)41988-0 |pmid= 8300590 |doi-access=free }}
• {{cite journal |vauthors=Yanase T, Hara T, Sakai Y, etal |title=Expression of sterol carrier protein 2 (SCP2) in human adrenocortical tissue |journal=Eur. J. Endocrinol. |volume=134 |issue= 4 |pages= 501–7 |year= 1996 |pmid= 8640304 |doi=10.1530/eje.0.1340501 }}
• {{cite journal |vauthors=Stolowich NJ, Frolov A, Atshaves B, etal |title=The sterol carrier protein-2 fatty acid binding site: an NMR, circular dichroic, and fluorescence spectroscopic determination |journal=Biochemistry |volume=36 |issue= 7 |pages= 1719–29 |year= 1997 |pmid= 9048555 |doi= 10.1021/bi962317a }}
• {{cite journal |vauthors=Schalk JA, Offenberg HH, Peters E, etal |title=Isolation and characterization of the human SCP2 cDNA and chromosomal localization of the gene |journal=Mamm. Genome |volume=10 |issue= 6 |pages= 642–4 |year= 1999 |pmid= 10341103 |doi=10.1007/s003359901062 |s2cid=9107396 }}
• {{cite journal |vauthors=Jatzke C, Hinz HJ, Seedorf U, Assmann G |title=Stability and binding properties of wild-type and c17s mutated human sterol carrier protein 2 |journal=Biochim. Biophys. Acta |volume=1432 |issue= 2 |pages= 265–74 |year= 1999 |pmid= 10407148 |doi=10.1016/S0167-4838(99)00114-4 }}
• {{cite journal |vauthors=Kimura H, Fujii H, Suzuki S, etal |title=Lipid-binding proteins in rat and human kidney |journal=Kidney Int. Suppl. |volume=71 |pages= S159–62 |year= 1999 |pmid= 10412765 |doi=10.1046/j.1523-1755.1999.07141.x |doi-access=free }}
• {{cite journal |vauthors=Huang H, Ball JM, Billheimer JT, Schroeder F |title=The sterol carrier protein-2 amino terminus: a membrane interaction domain |journal=Biochemistry |volume=38 |issue= 40 |pages= 13231–43 |year= 1999 |pmid= 10529196 |doi=10.1021/bi990870x }}

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Category:EC 2.3.1

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