Login
Login

SF3A3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.{{cite journal |author1=Kramer A |author2=Legrain P |author3=Mulhauser F |author4=Groning K |author5=Brosi R |author6=Bilbe G | title = Splicing factor SF3a60 is the mammalian homologue of PRP9 of S.cerevisiae: the conserved zinc finger-like motif is functionally exchangeable in vivo | journal = Nucleic Acids Res | volume = 22 | issue = 24 | pages = 5223–8 |date=February 1995 | pmid = 7816610 | pmc = 332064 | doi =10.1093/nar/22.24.5223 }}{{cite journal |author1=Chiara MD |author2=Champion-Arnaud P |author3=Buvoli M |author4=Nadal-Ginard B |author5=Reed R | title = Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114 | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 14 | pages = 6403–7 |date=August 1994 | pmid = 8022796 | pmc = 44210 | doi =10.1073/pnas.91.14.6403 |bibcode=1994PNAS...91.6403C |doi-access=free }}{{cite web | title = Entrez Gene: SF3A3 splicing factor 3a, subunit 3, 60kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10946}}

This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.

Interactions

SF3A3 has been shown to interact with SF3A1.{{cite journal |last=Nesic |first=D |author2=Krämer A |date=October 2001 |title=Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation |journal=Mol. Cell. Biol. |volume=21 |issue=19 |pages=6406–17 |location = United States| issn = 0270-7306| pmid = 11533230 |doi=10.1128/MCB.21.19.6406-6417.2001 |pmc=99788 }}

References

{{Reflist}}

Further reading

{{Refbegin | 2}}

  • {{cite journal |author1=Maruyama K |author2=Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal |author1=Bonaldo MF |author2=Lennon G |author3=Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal |vauthors=Neubauer G, King A, Rappsilber J, etal |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 |s2cid=585778 |url=http://nbn-resolving.de/urn:nbn:de:bvb:12-bsb00084516-7 }}
  • {{cite journal |author1=Das R |author2=Zhou Z |author3=Reed R |title=Functional association of U2 snRNP with the ATP-independent spliceosomal complex E |journal=Mol. Cell |volume=5 |issue= 5 |pages= 779–87 |year= 2000 |pmid= 10882114 |doi=10.1016/S1097-2765(00)80318-4 |doi-access=free }}
  • {{cite journal |vauthors=Will CL, Schneider C, MacMillan AM, etal |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536–46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536 | pmc=125580 }}
  • {{cite journal |author1=Nesic D |author2=Krämer A |title=Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation |journal=Mol. Cell. Biol. |volume=21 |issue= 19 |pages= 6406–17 |year= 2001 |pmid= 11533230 |doi=10.1128/MCB.21.19.6406-6417.2001 | pmc=99788 }}
  • {{cite journal |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088 | pmc=1370266 }}
  • {{cite journal |vauthors=Will CL, Urlaub H, Achsel T, etal |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein |journal=EMBO J. |volume=21 |issue= 18 |pages= 4978–88 |year= 2002 |pmid= 12234937 |doi=10.1093/emboj/cdf480 | pmc=126279 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |author1=Dubois T |author2=Zemlickova E |author3=Howell S |author4=Aitken A |title=Centaurin-alpha 1 associates in vitro and in vivo with nucleolin |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 502–8 |year= 2003 |pmid= 12565890 |doi=10.1016/S0006-291X(02)03010-3 }}
  • {{cite journal |vauthors=Li J, Hawkins IC, Harvey CD, etal |title=Regulation of alternative splicing by SRrp86 and its interacting proteins |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=10.1128/MCB.23.21.7437-7447.2003 | pmc=207616 }}
  • {{cite journal |author1=Nesic D |author2=Tanackovic G |author3=Krämer A |title=A role for Cajal bodies in the final steps of U2 snRNP biogenesis |journal=J. Cell Sci. |volume=117 |issue= Pt 19 |pages= 4423–33 |year= 2005 |pmid= 15316075 |doi= 10.1242/jcs.01308 |doi-access=free }}
  • {{cite journal |author1=Lin KT |author2=Lu RM |author3=Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004 | pmc=517884 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |s2cid=7200157 }}
  • {{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |bibcode=2005Natur.433...77A |s2cid=4344740 }}
  • {{cite journal |author1=Tanackovic G |author2=Krämer A |title=Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo |journal=Mol. Biol. Cell |volume=16 |issue= 3 |pages= 1366–77 |year= 2005 |pmid= 15647371 |doi= 10.1091/mbc.E04-11-1034 | pmc=551499 }}

{{Refend}}

{{PDB Gallery|geneid=10946}}

{{Gene-1-stub}}