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SH3BGRL3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

SH3 domain-binding glutamic acid-rich-like protein 3 is a protein that in humans is encoded by the SH3BGRL3 gene.{{cite web | title = Entrez Gene: SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83442}}

The 10.5kDa protein SH3 binding glutamic acid-rich protein-like 3 has an isoelectric point of 5.0. SH3 binding glutamic acid-rich (SH3BGR) gene is located to human chromosome 21. Two homologous genes, SH3BGRL and SH3BGRL3 are located to chromosome Xq13.3 and 1p34.3-35, respectively and code for small proteins similar to the N-terminal region of the SH3BGR protein.{{cite journal | vauthors = Egeo A, Mazzocco M, Arrigo P, Vidal-Taboada JM, Oliva R, Pirola B, Giglio S, Rasore-Quartino A, Scartezzini P | title = Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene | journal = Biochem. Biophys. Res. Commun. | volume = 247 | issue = 2 | pages = 302–6 |date=June 1998 | pmid = 9642120 | doi = 10.1006/bbrc.1998.8763 }} SH3BGRL3 protein shows a significant similarity to glutaredoxin 1 of E. coli, and all the three proteins are predicted to belong to thioredoxin-like protein family. Glutaredoxins (GRXs) are ubiquitous oxidoreductases, which catalyze the reduction of many intra-cellular protein disulfides and play an important role in many redox pathways. However, the SH3BGRL3 protein lacks the enzymatic function of glutaredoxins and may have a role as a regulator of redox activity.{{cite journal | vauthors = Mazzocco M, Maffei M, Egeo A, Vergano A, Arrigo P, Di Lisi R, Ghiotto F, Scartezzini P | title = The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily | journal = Gene | volume = 291 | issue = 1–2 | pages = 233–9 |date=May 2002 | pmid = 12095696 | doi = 10.1016/S0378-1119(02)00602-9}}

Role in cancer

Proteins such as glutaredoxin and thioredoxin are reported as up-regulated in many cancers such as lung and pancreatic; they have been implicated in increased resistance of cancer cells to free-radicals. There is little current evidence which directly links SH3GRPL3 with survival in cancer cells, however the protein has recently been identified as up-regulated in glioblastoma multiforme compared to normal cerebral tissue on proteomic analysis.{{cite journal | vauthors = Khalil AA, James P | title = Biomarker discovery: a proteomic approach for brain cancer profiling | journal = Cancer Sci. | volume = 98 | issue = 2 | pages = 201–13 |date=February 2007 | pmid = 17233837 | doi = 10.1111/j.1349-7006.2007.00374.x | doi-access = free | pmc = 11158801 }} Studies of acute promyelocytic leukemia cell line NB4 have also reported up-regulation of the protein. Conversely, the related protein SH3BGRL is reported to be downregulated in fibroblasts, lymphoid cells, and splenic tumor cells transformed by the viral oncogene v-Rel.{{cite journal | vauthors = Majid SM, Liss AS, You M, Bose HR | title = The suppression of SH3BGRL is important for v-Rel-mediated transformation | journal = Oncogene | volume = 25 | issue = 5 | pages = 756–68 |date=February 2006 | pmid = 16186799 | doi = 10.1038/sj.onc.1209107 | doi-access = free }} Co-expression of SH3BGRL with v-Rel in primary splenic lymphocytes reduced the number of colonies formed by 76%. Xu et al. reported SH3BGRPL3 protein as a post-translational modification of the 27kDa tumor necrosis factor alpha (TNF-α) inhibitory protein, TIP-B1. This protein is potentially involved in resistance of cells to the apoptosis-inducing effect of TNF-α.{{cite journal | vauthors = Xu C, Zheng P, Shen S, Xu Y, Wei L, Gao H, Wang S, Zhu C, Tang Y, Wu J, Zhang Q, Shi Y | title = NMR structure and regulated expression in APL cell of human SH3BGRL3 | journal = FEBS Lett. | volume = 579 | issue = 13 | pages = 2788–94 |date=May 2005 | pmid = 15907482 | doi = 10.1016/j.febslet.2005.04.011 | doi-access = free }}

References

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Further reading

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  • {{cite journal |vauthors=Xu C, Zheng P, Shen S, etal |title=NMR structure and regulated expression in APL cell of human SH3BGRL3. |journal=FEBS Lett. |volume=579 |issue= 13 |pages= 2788–94 |year= 2005 |pmid= 15907482 |doi= 10.1016/j.febslet.2005.04.011 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Mazzocco M, Arrigo P, Egeo A, etal |title=A novel human homologue of the SH3BGR gene encodes a small protein similar to Glutaredoxin 1 of Escherichia coli. |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 2 |pages= 540–5 |year= 2001 |pmid= 11444877 |doi= 10.1006/bbrc.2001.5169 }}
  • {{cite journal | vauthors=Henn AD, Berleth ES, Mihich E, Ehrke MJ |title=Changes in cytosolic and membrane TNF inhibitory protein-B1 (TIP-B1) levels associated with protection from TNF-induced cytotoxicity. |journal=FASEB J. |volume=15 |issue= 7 |pages= 1315–7 |year= 2001 |pmid= 11344125 |doi= 10.1096/fj.00-0543fje|s2cid=11425834 |doi-access=free }}
  • {{cite journal | vauthors=Seo J, Kim M, Kim J |title=Identification of novel genes differentially expressed in PMA-induced HL-60 cells using cDNA microarrays. |journal=Mol. Cells |volume=10 |issue= 6 |pages= 733–9 |year= 2001 |pmid= 11211881 |doi=10.1007/s10059-000-0733-x |s2cid=10539699 }}
  • {{cite journal |vauthors=Berleth ES, Henn AD, Gurtoo HL, etal |title=A novel tumor necrosis factor-alpha inhibitory protein, TIP-B1. |journal=Int. J. Immunopharmacol. |volume=22 |issue= 12 |pages= 1137–42 |year= 2001 |pmid= 11137621 |doi=10.1016/S0192-0561(00)00071-0 }}
  • {{cite journal |vauthors=Berleth ES, Nadadur S, Henn AD, etal |title=Identification, characterization, and cloning of TIP-B1, a novel protein inhibitor of tumor necrosis factor-induced lysis. |journal=Cancer Res. |volume=59 |issue= 21 |pages= 5497–506 |year= 1999 |pmid= 10554026 }}

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