SIRPG
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.{{cite journal | vauthors = Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M | title = Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family | journal = J Hum Genet | volume = 45 | issue = 6 | pages = 378–82 |date=Jan 2001 | pmid = 11185750 | doi = 10.1007/s100380070013 | doi-access = free }}{{cite journal | vauthors = van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN | title = A nomenclature for signal regulatory protein family members | journal = J Immunol | volume = 175 | issue = 12 | pages = 7788–9 |date=Dec 2005 | pmid = 16339511 | doi = 10.4049/jimmunol.175.12.7788| doi-access = free }}{{cite web | title = Entrez Gene: SIRPG signal-regulatory protein gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55423}} SIRPG has also recently been designated CD172G (cluster of differentiation 172G).
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.
References
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Further reading
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- {{cite journal |vauthors=Kharitonenkov A, Chen Z, Sures I, etal |title=A family of proteins that inhibit signalling through tyrosine kinase receptors |journal=Nature |volume=386 |issue= 6621 |pages= 181–6 |year= 1997 |pmid= 9062191 |doi= 10.1038/386181a0 |bibcode=1997Natur.386..181K |s2cid=4259314 }}
- {{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Brooke G, Holbrook JD, Brown MH, Barclay AN |title=Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family |journal=J. Immunol. |volume=173 |issue= 4 |pages= 2562–70 |year= 2004 |pmid= 15294972 |doi= 10.4049/jimmunol.173.4.2562|doi-access=free }}
- {{cite journal |vauthors=Piccio L, Vermi W, Boles KS, etal |title=Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation |journal=Blood |volume=105 |issue= 6 |pages= 2421–7 |year= 2006 |pmid= 15383453 |doi= 10.1182/blood-2004-07-2823 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
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External links
- [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q9P1W8 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma (SIRPG)
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{{Clusters of differentiation}}
Category:Clusters of differentiation
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