signal-regulatory protein

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| Symbol = SRP

| Name = Signal-regulatory protein

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A Signal-regulatory protein (SIRP) is one of a family of transmembrane glycoproteins involved in immunological signalling, expressed mainly by myeloid cells.{{cite journal | vauthors = van Beek EM, Cochrane F, Barclay AN, van den Berg TK | title = Signal regulatory proteins in the immune system | journal = Journal of Immunology | volume = 175 | issue = 12 | pages = 7781–7 | date = December 2005 | pmid = 16339510 | doi = 10.4049/jimmunol.175.12.7781 | doi-access = free }}{{cite journal | vauthors = Barclay AN, Brown MH | title = The SIRP family of receptors and immune regulation | journal = Nature Reviews. Immunology | volume = 6 | issue = 6 | pages = 457–64 | date = June 2006 | pmid = 16691243 | doi = 10.1038/nri1859 | s2cid = 7915923 }}

Members include :

• Signal-regulatory protein alpha, ligand=CD47
• SIRPB1
• SIRPB2{{cite journal | vauthors = Visser N, Nelemans LC, He Y, Lourens HJ, Corrales MG, Huls G, Wiersma VR, Schuringa JJ, Bremer E | title = Signal regulatory protein beta 2 is a novel positive regulator of innate anticancer immunity | journal = Frontiers in Immunology | volume = 14 | pages = 1287256 | date = December 2023 | pmid = 38116002 | doi = 10.3389/fimmu.2023.1287256 | doi-access = free }}
• SIRPD
• SIRPG, ligand=CD47