SMIM11
{{infobox gene}}
Small integral membrane protein 11 is a protein which in humans is encoded by the SMIM11 gene.{{Cite web |url=https://www.uniprot.org/uniprot/P58511 |title=P58511 · SIM11_HUMAN|website=www.uniprot.org |publisher=UniProt|access-date=2022-12-23}}{{cite web |url= https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&list_uids=54065 |title=SMIM11 small integral membrane protein 11 [ Homo sapiens (human) ] |publisher=National Center for Biotechnology Information, U.S. National Library of Medicine |website= ncbi.nlm.nih.gov|access-date=2022-12-23}}
Gene
=[[Locus (genetics)|Locus]]=
SMIM11 is located on the plus strand of chromosome 21 and has 4 exons.
= Expression =
[[Messenger RNA|mRNA]]
There are no known transcript variants or isoforms of SMIM11.{{cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=SMIM11A#snp|title=SMIM11A Protein Coding|website=genecards.org}}
Protein
The SMIM11 protein is 58 amino acids long. The theoretical molecular weight of this protein is 6kDa and the theoretical pI is 9.{{cite web |url=https://web.expasy.org/compute_pi/ |title= Compute pI/Mw Tool Expasy |website=expasy.org}} The protein is localized in the cytoplasm and mitochondria, as well as focal adhesion points between the cells.{{cite web |url=https://psort.hgc.jp/form2.html |title=PSORT II Server|website=psort.hgc.jp}}{{cite web|url=https://www.proteinatlas.org/ENSG00000205670-SMIM11A/antibody |title= Immunohistochemistry of SMIM11A: The Human Protein Atlas|website=proteinatlas.org}}
= Domains, Motifs, and [[Post-translational modification|Post-translational Modifications]]=
SMIM11 contains a transmembrane domain.{{cite web|url= https://www.ncbi.nlm.nih.gov/nuccore/NM_058182.4?report=genbank|title=Homo sapiens small integral membrane protein 11A (SMIM11A), mRNA |publisher=NCBI (National Center for Biotechnology Information) |website= ncbi.nlm.nih.gov}} The protein also holds a dileucine motif. Post-translational modifications include ubiquitylation site, as well as two phosphorylated sites, one on a threonine and one on a serine{{cite web|url= https://research.bioinformatics.udel.edu/iptmnet/entry/P58511/|title=iPTMnet Report for P58511 (SMIM11A)|website=research.bioinformatics.udel.edu}}{{cite web |url=http://www.cbs.dtu.dk/services/NetPhos/ |title=NetPhos 3.1 Server|website=cbs.dtu.dk}}
=[[Protein secondary structure|Secondary Structure]] and [[Protein tertiary structure|Tertiary Structure]]=
The protein is composed mostly of alpha-helices.{{cite web|url=http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/b05a738fd4deeae0/summary.html|title=Phyre2 Results|website=sbg.bio.ic.ac.uk}} The N-terminus of SMIM11 sticks out into the extracellular matrix, while the C-terminal end is located within the cytoplasm of the cell.{{cite web|url=http://www.cbs.dtu.dk/services/TMHMM-2.0/|title=TMHHM Server |website=cbs.dtu.dk}}
=[[Protein quaternary structure|Quaternary Structure]] and Protein Interactions =
Experimentally-determined protein interactions for SMIM11 have not yet been identified.{{cite web|url=https://string-db.org/cgi/network.pl?taskId=yBcjFuOJy5Y0|title=STRING FAM165B|website=string-db.org}}
Homology and Evolution
= Paralogs =
No paralogs or paralogous domains exist for SMIM11
= Orthologs =
SMIM11 has a large number of orthologs. These orthologs range from other mammals to birds, reptiles, amphibians, and bony fish.{{cite web|url=https://blast.ncbi.nlm.nih.gov/Blast.cgi|title=NCBI Protein Blast |website=blast.ncbi.nlm.nih.gov}}
References
{{reflist}}