SNW1

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.

SNW1 has been shown to interact with:

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• CIR,
• Calcitriol receptor,
• Histone deacetylase 2,{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD | title = A role for SKIP in EBNA2 activation of CBF1-repressed promoters | journal = Journal of Virology | volume = 74 | issue = 4 | pages = 1939–47 | date = Feb 2000 | pmid = 10644367 | pmc = 111672 | doi = 10.1128/jvi.74.4.1939-1947.2000}}
• Mothers against decapentaplegic homolog 2,
• Mothers against decapentaplegic homolog 3,
• NOTCH1{{cite journal | vauthors = Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U | title = The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity | journal = Mechanisms of Development | volume = 104 | issue = 1–2 | pages = 3–20 | date = Jun 2001 | pmid = 11404076 | doi = 10.1016/s0925-4773(01)00373-2| doi-access = free }}
• Nuclear receptor co-repressor 2,
• Nuclear receptor coactivator 1,{{cite journal | vauthors = Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN | title = Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription | journal = The Journal of Biological Chemistry | volume = 276 | issue = 44 | pages = 40614–20 | date = Nov 2001 | pmid = 11514567 | doi = 10.1074/jbc.M106263200 | doi-access = free }}
• PABPN1,{{cite journal | vauthors = Kim YJ, Noguchi S, Hayashi YK, Tsukahara T, Shimizu T, Arahata K | title = The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression | journal = Human Molecular Genetics | volume = 10 | issue = 11 | pages = 1129–39 | date = May 2001 | pmid = 11371506 | doi = 10.1093/hmg/10.11.1129| doi-access = free }}
• RBPJ,{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD | title = SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2400–10 | date = Apr 2000 | pmid = 10713164 | pmc = 85419 | doi = 10.1128/mcb.20.7.2400-2410.2000}}
• Retinoblastoma protein,{{cite journal | vauthors = Prathapam T, Kühne C, Banks L | title = Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity | journal = Nucleic Acids Research | volume = 30 | issue = 23 | pages = 5261–8 | date = Dec 2002 | pmid = 12466551 | pmc = 137971 | doi = 10.1093/nar/gkf658}} and
• SKI protein.{{cite journal | vauthors = Prathapam T, Kühne C, Hayman M, Banks L | title = Ski interacts with the evolutionarily conserved SNW domain of Skip | journal = Nucleic Acids Research | volume = 29 | issue = 17 | pages = 3469–76 | date = Sep 2001 | pmid = 11522815 | pmc = 55893 | doi = 10.1093/nar/29.17.3469}}{{cite journal | vauthors = Dahl R, Wani B, Hayman MJ | title = The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42 | journal = Oncogene | volume = 16 | issue = 12 | pages = 1579–86 | date = Mar 1998 | pmid = 9569025 | doi = 10.1038/sj.onc.1201687 | doi-access = free }}{{cite journal | vauthors = Leong GM, Subramaniam N, Figueroa J, Flanagan JL, Hayman MJ, Eisman JA, Kouzmenko AP | title = Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 18243–8 | date = May 2001 | pmid = 11278756 | doi = 10.1074/jbc.M010815200 | doi-access = free }}

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{{Reflist}}

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• {{cite journal | vauthors = Dahl R, Wani B, Hayman MJ | title = The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42 | journal = Oncogene | volume = 16 | issue = 12 | pages = 1579–86 | date = Mar 1998 | pmid = 9569025 | doi = 10.1038/sj.onc.1201687 | doi-access = free }}
• {{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD | title = A role for SKIP in EBNA2 activation of CBF1-repressed promoters | journal = Journal of Virology | volume = 74 | issue = 4 | pages = 1939–47 | date = Feb 2000 | pmid = 10644367 | pmc = 111672 | doi = 10.1128/JVI.74.4.1939-1947.2000 }}
• {{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD | title = SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2400–10 | date = Apr 2000 | pmid = 10713164 | pmc = 85419 | doi = 10.1128/MCB.20.7.2400-2410.2000 }}
• {{cite journal | vauthors = Leong GM, Subramaniam N, Figueroa J, Flanagan JL, Hayman MJ, Eisman JA, Kouzmenko AP | title = Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 18243–8 | date = May 2001 | pmid = 11278756 | doi = 10.1074/jbc.M010815200 | doi-access = free }}
• {{cite journal | vauthors = Kim YJ, Noguchi S, Hayashi YK, Tsukahara T, Shimizu T, Arahata K | title = The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression | journal = Human Molecular Genetics | volume = 10 | issue = 11 | pages = 1129–39 | date = May 2001 | pmid = 11371506 | doi = 10.1093/hmg/10.11.1129 | doi-access = free }}
• {{cite journal | vauthors = Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U | title = The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity | journal = Mechanisms of Development | volume = 104 | issue = 1–2 | pages = 3–20 | date = Jun 2001 | pmid = 11404076 | doi = 10.1016/S0925-4773(01)00373-2 | doi-access = free }}
• {{cite journal | vauthors = Zhou S, Hayward SD | title = Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex | journal = Molecular and Cellular Biology | volume = 21 | issue = 18 | pages = 6222–32 | date = Sep 2001 | pmid = 11509665 | pmc = 87339 | doi = 10.1128/MCB.21.18.6222-6232.2001 }}
• {{cite journal | vauthors = Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN | title = Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription | journal = The Journal of Biological Chemistry | volume = 276 | issue = 44 | pages = 40614–20 | date = Nov 2001 | pmid = 11514567 | doi = 10.1074/jbc.M106263200 | doi-access = free }}
• {{cite journal | vauthors = Prathapam T, Kühne C, Hayman M, Banks L | title = Ski interacts with the evolutionarily conserved SNW domain of Skip | journal = Nucleic Acids Research | volume = 29 | issue = 17 | pages = 3469–76 | date = Sep 2001 | pmid = 11522815 | pmc = 55893 | doi = 10.1093/nar/29.17.3469 }}
• {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | date = Apr 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
• {{cite journal | vauthors = Wardell SE, Boonyaratanakornkit V, Adelman JS, Aronheim A, Edwards DP | title = Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator | journal = Molecular and Cellular Biology | volume = 22 | issue = 15 | pages = 5451–66 | date = Aug 2002 | pmid = 12101239 | pmc = 133955 | doi = 10.1128/MCB.22.15.5451-5466.2002 }}
• {{cite journal | vauthors = Prathapam T, Kühne C, Banks L | title = Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity | journal = Nucleic Acids Research | volume = 30 | issue = 23 | pages = 5261–8 | date = Dec 2002 | pmid = 12466551 | pmc = 137971 | doi = 10.1093/nar/gkf658 }}
• {{cite journal | vauthors = Petersen HH, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek AJ, Willnow TE | title = Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule | journal = Journal of Cell Science | volume = 116 | issue = Pt 3 | pages = 453–61 | date = Feb 2003 | pmid = 12508107 | doi = 10.1242/jcs.00243 | doi-access = free }}
• {{cite journal | vauthors = Barry JB, Leong GM, Church WB, Issa LL, Eisman JA, Gardiner EM | title = Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues | journal = The Journal of Biological Chemistry | volume = 278 | issue = 10 | pages = 8224–8 | date = Mar 2003 | pmid = 12529369 | doi = 10.1074/jbc.C200712200 | doi-access = free }}
• {{cite journal | vauthors = Zhang C, Dowd DR, Staal A, Gu C, Lian JB, van Wijnen AJ, Stein GS, MacDonald PN | title = Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing | journal = The Journal of Biological Chemistry | volume = 278 | issue = 37 | pages = 35325–36 | date = Sep 2003 | pmid = 12840015 | doi = 10.1074/jbc.M305191200 | doi-access = free }}
• {{cite journal | vauthors = Leong GM, Subramaniam N, Issa LL, Barry JB, Kino T, Driggers PH, Hayman MJ, Eisman JA, Gardiner EM | title = Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300 | journal = Biochemical and Biophysical Research Communications | volume = 315 | issue = 4 | pages = 1070–6 | date = Mar 2004 | pmid = 14985122 | doi = 10.1016/j.bbrc.2004.02.004 }}

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