Nuclear receptor co-repressor 2

NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains. NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.{{cite journal | vauthors = Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM | title = Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase | journal = Cell | volume = 89 | issue = 3 | pages = 373–80 | date = May 1997 | pmid = 9150137 | doi = 10.1016/S0092-8674(00)80218-4 | s2cid = 14686941 | doi-access = free }}

It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 1.UniProt [https://www.uniprot.org/uniprot/?query=family:%22N-CoR+nuclear+receptor+corepressors+family%22 Nuclear receptor corepressors family] Page accessed June 26, 2016

SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies. In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.

Nuclear receptor co-repressor 2 has been shown to interact with:

{{div col|colwidth=20em}}

• AR,{{cite journal | vauthors = Liao G, Chen LY, Zhang A, Godavarthy A, Xia F, Ghosh JC, Li H, Chen JD | title = Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT | journal = The Journal of Biological Chemistry | volume = 278 | issue = 7 | pages = 5052–61 | date = February 2003 | pmid = 12441355 | doi = 10.1074/jbc.M206374200 | doi-access = free }}{{cite journal | vauthors = Song LN, Coghlan M, Gelmann EP | title = Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor | journal = Molecular Endocrinology | volume = 18 | issue = 1 | pages = 70–85 | date = January 2004 | pmid = 14593076 | doi = 10.1210/me.2003-0189 | doi-access = free }}{{cite journal | vauthors = Dotzlaw H, Moehren U, Mink S, Cato AC, Iñiguez Lluhí JA, Baniahmad A | title = The amino terminus of the human AR is target for corepressor action and antihormone agonism | journal = Molecular Endocrinology | volume = 16 | issue = 4 | pages = 661–73 | date = April 2002 | pmid = 11923464 | doi = 10.1210/me.16.4.661 | doi-access = free }}
• BCL6,{{cite journal | vauthors = Huynh KD, Fischle W, Verdin E, Bardwell VJ | title = BCoR, a novel corepressor involved in BCL-6 repression | journal = Genes & Development | volume = 14 | issue = 14 | pages = 1810–23 | date = July 2000 | pmid = 10898795 | pmc = 316791 | doi = 10.1101/gad.14.14.1810 }}{{cite journal | vauthors = Deltour S, Guerardel C, Leprince D | title = Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 26 | pages = 14831–6 | date = December 1999 | pmid = 10611298 | pmc = 24733 | doi = 10.1073/pnas.96.26.14831 | bibcode = 1999PNAS...9614831D | doi-access = free }}
• C-Fos,{{cite journal | vauthors = Lee SK, Kim JH, Lee YC, Cheong J, Lee JW | title = Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor | journal = The Journal of Biological Chemistry | volume = 275 | issue = 17 | pages = 12470–4 | date = April 2000 | pmid = 10777532 | doi = 10.1074/jbc.275.17.12470 | doi-access = free }}
• C-jun,
• HDAC1,{{cite journal | vauthors = Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, Cohen D | title = Isolation and characterization of a novel class II histone deacetylase, HDAC10 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6656–66 | date = February 2002 | pmid = 11739383 | doi = 10.1074/jbc.M108055200 | doi-access = free }}{{cite journal | vauthors = Underhill C, Qutob MS, Yee SP, Torchia J | title = A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 51 | pages = 40463–70 | date = December 2000 | pmid = 11013263 | doi = 10.1074/jbc.M007864200 | doi-access = free }}
• HDAC3,{{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Molecular Cell | volume = 12 | issue = 3 | pages = 723–34 | date = September 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008 | doi-access = free }}
• HDAC4,{{cite journal | vauthors = Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E | title = Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR | journal = Molecular Cell | volume = 9 | issue = 1 | pages = 45–57 | date = January 2002 | pmid = 11804585 | doi = 10.1016/S1097-2765(01)00429-4 | hdl = 11858/00-001M-0000-002C-9FF9-9 | hdl-access = free }}
• HDAC5,
• HDAC10,
• MeCP2,{{cite journal | vauthors = Lyst MJ, Ekiert R, Ebert DH, Merusi C, Nowak J, Selfridge J, Guy J, Kastan NR, Robinson ND, de Lima Alves F, Rappsilber J, Greenberg ME, Bird A | title = Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor | journal = Nature Neuroscience | volume = 16 | issue = 7 | pages = 898–902 | date = July 2013 | pmid = 23770565 | doi = 10.1038/nn.3434 | pmc=3786392}}
• NR4A1,{{cite journal | vauthors = Sohn YC, Kwak E, Na Y, Lee JW, Lee SK | title = Silencing mediator of retinoid and thyroid hormone receptors and activating signal cointegrator-2 as transcriptional coregulators of the orphan nuclear receptor Nur77 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 47 | pages = 43734–9 | date = November 2001 | pmid = 11559707 | doi = 10.1074/jbc.M107208200 | doi-access = free }}
• POU2F1,{{cite journal | vauthors = Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J, Kumagai M, Yamashita K, Hashizume K | title = Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor | journal = The Journal of Biological Chemistry | volume = 276 | issue = 13 | pages = 9720–5 | date = March 2001 | pmid = 11134019 | doi = 10.1074/jbc.M008531200 | doi-access = free }}
• PPARD,{{cite journal | vauthors = Shi Y, Hon M, Evans RM | title = The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 5 | pages = 2613–8 | date = March 2002 | pmid = 11867749 | pmc = 122396 | doi = 10.1073/pnas.052707099 | bibcode = 2002PNAS...99.2613S | doi-access = free }}
• PGR,{{cite journal | vauthors = Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP | title = The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding | journal = Molecular and Cellular Biology | volume = 20 | issue = 9 | pages = 3102–15 | date = May 2000 | pmid = 10757795 | pmc = 85605 | doi = 10.1128/MCB.20.9.3102-3115.2000 }}
• PML{{cite journal | vauthors = Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S | title = Role of PML and PML-RARalpha in Mad-mediated transcriptional repression | journal = Molecular Cell | volume = 7 | issue = 6 | pages = 1233–43 | date = June 2001 | pmid = 11430826 | doi = 10.1016/S1097-2765(01)00257-X | doi-access = free }}{{cite journal | vauthors = Hong SH, Yang Z, Privalsky ML | title = Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7172–82 | date = November 2001 | pmid = 11585900 | pmc = 99892 | doi = 10.1128/MCB.21.21.7172-7182.2001 }}
• RBPJ,{{cite journal | vauthors = Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U | title = The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity | journal = Mechanisms of Development | volume = 104 | issue = 1–2 | pages = 3–20 | date = June 2001 | pmid = 11404076 | doi = 10.1016/S0925-4773(01)00373-2 | s2cid = 9526831 | doi-access = free }}{{cite journal | vauthors = Zhou S, Hayward SD | title = Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex | journal = Molecular and Cellular Biology | volume = 21 | issue = 18 | pages = 6222–32 | date = September 2001 | pmid = 11509665 | pmc = 87339 | doi = 10.1128/MCB.21.18.6222-6232.2001 }}
• RELA,{{cite journal | vauthors = Espinosa L, Inglés-Esteve J, Robert-Moreno A, Bigas A | title = IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFkappaB pathways | journal = Molecular Biology of the Cell | volume = 14 | issue = 2 | pages = 491–502 | date = February 2003 | pmid = 12589049 | pmc = 149987 | doi = 10.1091/mbc.E02-07-0404 }}
• RUNX1T1,{{cite journal | vauthors = Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA | title = Oligomerization of ETO is obligatory for corepressor interaction | journal = Molecular and Cellular Biology | volume = 21 | issue = 1 | pages = 156–63 | date = January 2001 | pmid = 11113190 | pmc = 88789 | doi = 10.1128/MCB.21.1.156-163.2001 }}
• RARA,{{cite journal | vauthors = Dong S, Tweardy DJ | title = Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways | journal = Blood | volume = 99 | issue = 8 | pages = 2637–46 | date = April 2002 | pmid = 11929748 | doi = 10.1182/blood.V99.8.2637 | doi-access = free }}{{cite journal | vauthors = Hong SH, David G, Wong CW, Dejean A, Privalsky ML | title = SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 17 | pages = 9028–33 | date = August 1997 | pmid = 9256429 | pmc = 23013 | doi = 10.1073/pnas.94.17.9028 | bibcode = 1997PNAS...94.9028H | doi-access = free }}
• SIN3A,{{cite journal | vauthors = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | journal = The EMBO Journal | volume = 19 | issue = 16 | pages = 4342–50 | date = August 2000 | pmid = 10944117 | pmc = 302030 | doi = 10.1093/emboj/19.16.4342 }}{{cite journal | vauthors = Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA | title = Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway | journal = Genes & Development | volume = 14 | issue = 1 | pages = 45–54 | date = January 2000 | doi = 10.1101/gad.14.1.45 | pmid = 10640275 | pmc = 316335 }}
• SNW1,{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD | title = A role for SKIP in EBNA2 activation of CBF1-repressed promoters | journal = Journal of Virology | volume = 74 | issue = 4 | pages = 1939–47 | date = February 2000 | pmid = 10644367 | pmc = 111672 | doi = 10.1128/JVI.74.4.1939-1947.2000 }}{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD | title = SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2400–10 | date = April 2000 | pmid = 10713164 | pmc = 85419 | doi = 10.1128/MCB.20.7.2400-2410.2000 }}
• SPEN,{{cite journal | vauthors = Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM | title = Sharp, an inducible cofactor that integrates nuclear receptor repression and activation | journal = Genes & Development | volume = 15 | issue = 9 | pages = 1140–51 | date = May 2001 | pmid = 11331609 | pmc = 312688 | doi = 10.1101/gad.871201 }}
• SRF,
• TBL1X,{{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = The EMBO Journal | volume = 22 | issue = 6 | pages = 1336–46 | date = March 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }}{{cite journal | vauthors = Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA | title = Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex | journal = Genes & Development | volume = 16 | issue = 24 | pages = 3130–5 | date = December 2002 | pmid = 12502735 | pmc = 187500 | doi = 10.1101/gad.1037502 }}{{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | journal = Genes & Development | volume = 14 | issue = 9 | pages = 1048–57 | date = May 2000 | pmid = 10809664 | pmc = 316569 | doi = 10.1101/gad.14.9.1048 }}
• THRB,{{cite journal | vauthors = Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM | title = Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors | journal = Endocrinology | volume = 139 | issue = 10 | pages = 4197–204 | date = October 1998 | pmid = 9751500 | doi = 10.1210/endo.139.10.6218 | doi-access = free }}{{cite journal | vauthors = Tagami T, Lutz WH, Kumar R, Jameson JL | title = The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators | journal = Biochemical and Biophysical Research Communications | volume = 253 | issue = 2 | pages = 358–63 | date = December 1998 | pmid = 9878542 | doi = 10.1006/bbrc.1998.9799 }}{{cite journal | vauthors = Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, Zhang MQ, Oldfield EH, Yen PM | title = Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance | journal = Molecular Endocrinology | volume = 15 | issue = 9 | pages = 1529–38 | date = September 2001 | pmid = 11518802 | doi = 10.1210/mend.15.9.0687 | doi-access = free }}
• VDR,{{cite journal | vauthors = Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M | title = AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor | journal = Cancer Research | volume = 62 | issue = 23 | pages = 7050–8 | date = December 2002 | pmid = 12460926 }} and
• ZBTB16.{{cite journal | vauthors = Wong CW, Privalsky ML | title = Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27695–702 | date = October 1998 | pmid = 9765306 | doi = 10.1074/jbc.273.42.27695 | doi-access = free }}{{cite journal | vauthors = Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD | title = The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT | journal = Blood | volume = 103 | issue = 12 | pages = 4650–8 | date = June 2004 | pmid = 14982881 | doi = 10.1182/blood-2003-08-2759 | doi-access = free }}

{{Div col end}}

{{Reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK | title = Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor | journal = Nature | volume = 377 | issue = 6548 | pages = 397–404 | date = October 1995 | pmid = 7566114 | doi = 10.1038/377397a0 | bibcode = 1995Natur.377..397H | s2cid = 4230850 }}
• {{cite journal | vauthors = Chen JD, Evans RM | title = A transcriptional co-repressor that interacts with nuclear hormone receptors | journal = Nature | volume = 377 | issue = 6548 | pages = 454–7 | date = October 1995 | pmid = 7566127 | doi = 10.1038/377454a0 | bibcode = 1995Natur.377..454C | s2cid = 4361329 }}
• {{cite journal | vauthors = Sande S, Privalsky ML | title = Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors | journal = Molecular Endocrinology | volume = 10 | issue = 7 | pages = 813–25 | date = July 1996 | doi = 10.1210/mend.10.7.8813722 | pmid = 8813722 | doi-access = free }}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
• {{cite journal | vauthors = Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA | title = cDNAs with long CAG trinucleotide repeats from human brain | journal = Human Genetics | volume = 100 | issue = 1 | pages = 114–22 | date = July 1997 | pmid = 9225980 | doi = 10.1007/s004390050476 | s2cid = 25999127 }}
• {{cite journal | vauthors = Hong SH, David G, Wong CW, Dejean A, Privalsky ML | title = SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 17 | pages = 9028–33 | date = August 1997 | pmid = 9256429 | pmc = 23013 | doi = 10.1073/pnas.94.17.9028 | bibcode = 1997PNAS...94.9028H | doi-access = free }}
• {{cite journal | vauthors = Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM | title = Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300 | journal = Cell | volume = 90 | issue = 3 | pages = 569–80 | date = August 1997 | pmid = 9267036 | doi = 10.1016/S0092-8674(00)80516-4 | s2cid = 15284825 | doi-access = free }}
• {{cite journal | vauthors = Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM | title = Role of the histone deacetylase complex in acute promyelocytic leukaemia | journal = Nature | volume = 391 | issue = 6669 | pages = 811–4 | date = February 1998 | pmid = 9486654 | doi = 10.1038/35895 | bibcode = 1998Natur.391..811L | s2cid = 4383951 | doi-access = free }}
• {{cite journal | vauthors = Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN | title = SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors | journal = Molecular Cell | volume = 2 | issue = 1 | pages = 33–42 | date = July 1998 | pmid = 9702189 | doi = 10.1016/S1097-2765(00)80111-2 | doi-access = free }}
• {{cite journal | vauthors = Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM | title = Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors | journal = Endocrinology | volume = 139 | issue = 10 | pages = 4197–204 | date = October 1998 | pmid = 9751500 | doi = 10.1210/endo.139.10.6218 | doi-access = free }}
• {{cite journal | vauthors = Wong CW, Privalsky ML | title = Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27695–702 | date = October 1998 | pmid = 9765306 | doi = 10.1074/jbc.273.42.27695 | doi-access = free }}
• {{cite journal | vauthors = Ordentlich P, Downes M, Xie W, Genin A, Spinner NB, Evans RM | title = Unique forms of human and mouse nuclear receptor corepressor SMRT | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 6 | pages = 2639–44 | date = March 1999 | pmid = 10077563 | pmc = 15821 | doi = 10.1073/pnas.96.6.2639 | bibcode = 1999PNAS...96.2639O | doi-access = free }}
• {{cite journal | vauthors = Park EJ, Schroen DJ, Yang M, Li H, Li L, Chen JD | title = SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 7 | pages = 3519–24 | date = March 1999 | pmid = 10097068 | pmc = 22325 | doi = 10.1073/pnas.96.7.3519 | bibcode = 1999PNAS...96.3519P | doi-access = free }}
• {{cite journal | vauthors = Nguyen TA, Hoivik D, Lee JE, Safe S | title = Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex | journal = Archives of Biochemistry and Biophysics | volume = 367 | issue = 2 | pages = 250–7 | date = July 1999 | pmid = 10395741 | doi = 10.1006/abbi.1999.1282 }}
• {{cite journal | vauthors = Bailey P, Downes M, Lau P, Harris J, Chen SL, Hamamori Y, Sartorelli V, Muscat GE | title = The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD | journal = Molecular Endocrinology | volume = 13 | issue = 7 | pages = 1155–68 | date = July 1999 | pmid = 10406466 | doi = 10.1210/mend.13.7.0305 | doi-access = free }}
• {{cite journal | vauthors = Kao HY, Downes M, Ordentlich P, Evans RM | title = Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression | journal = Genes & Development | volume = 14 | issue = 1 | pages = 55–66 | date = January 2000 | pmid = 10640276 | pmc = 316336 | doi = 10.1101/gad.14.1.55 }}
• {{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD | title = SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2400–10 | date = April 2000 | pmid = 10713164 | pmc = 85419 | doi = 10.1128/MCB.20.7.2400-2410.2000 }}
• {{cite journal | vauthors = Lee SK, Kim JH, Lee YC, Cheong J, Lee JW | title = Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor | journal = The Journal of Biological Chemistry | volume = 275 | issue = 17 | pages = 12470–4 | date = April 2000 | pmid = 10777532 | doi = 10.1074/jbc.275.17.12470 | doi-access = free }}
• {{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | journal = Genes & Development | volume = 14 | issue = 9 | pages = 1048–57 | date = May 2000 | pmid = 10809664 | pmc = 316569 | doi = 10.1101/gad.14.9.1048 }}
• {{cite journal | vauthors = Grozinger CM, Schreiber SL | title = Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 14 | pages = 7835–40 | date = July 2000 | pmid = 10869435 | pmc = 16631 | doi = 10.1073/pnas.140199597 | bibcode = 2000PNAS...97.7835G | doi-access = free }}

{{refend}}

{{PDB Gallery|geneid=9612}}

{{Transcription coregulators}}

• {{MeshName|nuclear+receptor+corepressor+2|3=nuclear receptor corepressor 2}}
• {{NURSA|C98}}

Category:Transcription coregulators