STK33

{{Short description|Human DNA protein}}

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Serine/threonine kinase 33 is a protein that in humans is encoded by the STK33 gene.

STK33 was identified as a synthetic lethal gene in KRAS-dependent cell lines.{{cite book | vauthors = Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, Silkworth W, Dandapani S, Munoz B, Palmer M, Scherer C, Schreiber SL | chapter = Screen for Inhibitors of STK33 Kinase Activity | title = Probe Reports from the NIH Molecular Libraries Program [Internet]. | location = Bethesda (MD) | publisher = National Center for Biotechnology Information (US) | volume = | pages = | date = 2010| pmid = 23658944 | doi = | chapter-url = https://www.ncbi.nlm.nih.gov/books/NBK133418}}

STK33 has been considered as a target for reversible male contraceptives and the inhibitor CDD-2807 has been tested successfully in mice.{{cite web | url=https://www.nih.gov/news-events/nih-research-matters/drug-causes-reversible-male-contraception-mice | title=Drug causes reversible male contraception in mice | date=10 June 2024 }}