Sarah Teichmann

Teichmann was educated at the European School, Karlsruhe in Germany from 1981 to 1993 where she completed the European Baccalaureate in 1993.{{cite web |url=http://www.febs2015.org/Sarah-Teichmann.996.0.html |title=Sarah Teichmann: 40th FEBS Congress - The Biochemical Basis of Life - Berlin, Germany |publisher=Federation of European Biochemical Societies |year=2015|archive-date=2015-02-20|author=Anon

|archive-url=https://web.archive.org/web/20150220171117/http://www.febs2015.org/Sarah-Teichmann.996.0.html}} Teichmann went on to study the Natural Sciences Tripos at Trinity College, Cambridge and was awarded a first class Bachelor of Arts degree in 1996. In 1999, she completed her PhD supervised by Cyrus Chothia{{Cite journal | pmid = 12805536| year = 2003| last1 = Chothia| first1 = C| author-link1 = Cyrus Chothia| title = Evolution of the protein repertoire| journal = Science| volume = 300| issue = 5626| pages = 1701–3| last2 = Gough| first2 = J| author-link2 = Julian Gough (scientist)| last3 = Vogel| first3 = C| last4 = Teichmann| first4 = S. A.| author-link4 = Sarah Teichmann| doi = 10.1126/science.1085371| bibcode = 2003Sci...300.1701C| s2cid = 27681885}} at the Laboratory of Molecular Biology (LMB) on genome evolution.{{cite thesis |degree=PhD |first=Sarah Amalia|last=Teichmann |title=Genome evolution : analysing proteomes with new methods|publisher=University of Cambridge |date=1999 |oclc=894602472|url=http://ulmss-newton.lib.cam.ac.uk/vwebv/holdingsInfo?bibId=21461|id={{EThOS|uk.bl.ethos.624585}}}}

Following her PhD, Teichmann did postdoctoral research supervised by Janet Thornton at University College London and funded by the Beit Memorial Fellowships for Medical Research. From 2001-2012, she was a Medical Research Council (MRC) Programme Leader, studying patterns in protein interactions and transcriptional regulatory networks.{{Cite journal

| pmid = 15193307

| year = 2004

| last1 = Babu

| first1 = M. M.

| title = Structure and evolution of transcriptional regulatory networks

| journal = Current Opinion in Structural Biology

| volume = 14

| issue = 3

| pages = 283–91

| last2 = Luscombe

| first2 = N. M.

| last3 = Aravind

| first3 = L

| last4 = Gerstein

| first4 = M

| author-link4 = Mark Bender Gerstein

| last5 = Teichmann

| first5 = S. A.

| author-link5 = Sarah Teichmann

| doi = 10.1016/j.sbi.2004.05.004

| citeseerx = 10.1.1.471.9692

}}{{Cite journal

| pmid = 15372033

| year = 2004

| last1 = Luscombe

| first1 = N. M.

| title = Genomic analysis of regulatory network dynamics reveals large topological changes

| journal = Nature

| volume = 431

| issue = 7006

| pages = 308–12

| last2 = Babu

| first2 = M. M.

| last3 = Yu

| first3 = H

| last4 = Snyder

| first4 = M

| last5 = Teichmann

| first5 = S. A.

| author-link5 =Sarah Teichmann

| last6 = Gerstein

| first6 = M

| author-link6 = Mark Bender Gerstein

| doi = 10.1038/nature02782

| bibcode = 2004Natur.431..308L

| s2cid = 4391278

}}

In 2013 Teichmann was appointed a joint position at the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EMBL-EBI). From 2005 to 2015 she served as a teaching fellow and director of studies at Trinity College, Cambridge. Since 2016 Teichmann has served as the head of Cellular Genetics at the Wellcome Trust Sanger Institute and a visiting research group leader at the EBI.

Teichmann's research{{ACM Portal |name=Sarah A. Teichmann}}{{DBLP}}{{Scopus id}}{{EuropePMC |name=Sarah Teichmann}} investigates gene expression{{Cite journal

| pmid = 16141072

| year = 2005

| last1 = Carninci

| first1 = P

| title = The transcriptional landscape of the mammalian genome

| journal = Science

| volume = 309

| issue = 5740

| pages = 1559–63

| last2 = Kasukawa

| first2 = T

| last3 = Katayama

| first3 = S

| last4 = Gough

| first4 = J

| author-link4 = Julian Gough (scientist)

| last5 = Frith

| first5 = M. C.

| last6 = Maeda

| first6 = N

| last7 = Oyama

| first7 = R

| last8 = Ravasi

| first8 = T

| last9 = Lenhard

| first9 = B

| last10 = Wells

| first10 = C

| last11 = Kodzius

| first11 = R

| last12 = Shimokawa

| first12 = K

| last13 = Bajic

| first13 = V. B.

| last14 = Brenner | first14 = S. E. | author-link14 = Steven E. Brenner

| last15 = Batalov

| first15 = S

| last16 = Forrest

| first16 = A. R.

| last17 = Zavolan

| first17 = M

| last18 = Davis

| first18 = M. J.

| last19 = Wilming

| first19 = L. G.

| last20 = Aidinis

| first20 = V

| last21 = Allen

| first21 = J. E.

| last22 = Ambesi-Impiombato

| first22 = A

| last23 = Apweiler

| first23 = R

| author-link23 = Rolf Apweiler

| last24 = Aturaliya

| first24 = R. N.

| last25 = Bailey

| first25 = T. L.

| last26 = Bansal

| first26 = M

| last27 = Baxter

| first27 = L

| last28 = Beisel

| first28 = K. W.

| last29 = Bersano

| first29 = T

| last30 = Bono

| first30 = H

| display-authors = 29

| doi = 10.1126/science.1112014

| bibcode = 2005Sci...309.1559F

| s2cid = 8712839

}}{{Cite journal

| pmid = 17994087

| year = 2007

| author1 = ((Drosophila 12 Genomes Consortium))

| title = Evolution of genes and genomes on the Drosophila phylogeny

| journal = Nature

| volume = 450

| issue = 7167

| pages = 203–18

| last2 = Clark

| first2 = A. G.

| last3 = Eisen

| first3 = M. B.

| author-link3 = Michael Eisen

| last4 = Smith

| first4 = D. R.

| last5 = Bergman

| first5 = C. M.

| last6 = Oliver

| first6 = B

| last7 = Markow

| first7 = T. A.

| last8 = Kaufman

| first8 = T. C.

| last9 = Kellis

| first9 = M

| last10 = Gelbart

| first10 = W

| last11 = Iyer

| first11 = V. N.

| last12 = Pollard

| first12 = D. A.

| last13 = Sackton

| first13 = T. B.

| last14 = Larracuente

| first14 = A. M.

| last15 = Singh

| first15 = N. D.

| last16 = Abad

| first16 = J. P.

| last17 = Abt

| first17 = D. N.

| last18 = Adryan

| first18 = B

| last19 = Aguade

| first19 = M

| last20 = Akashi

| first20 = H

| last21 = Anderson

| first21 = W. W.

| last22 = Aquadro

| first22 = C. F.

| last23 = Ardell

| first23 = D. H.

| last24 = Arguello

| first24 = R

| last25 = Artieri

| first25 = C. G.

| last26 = Barbash

| first26 = D. A.

| last27 = Barker

| first27 = D

| last28 = Barsanti

| first28 = P

| last29 = Batterham

| first29 = P

| last30 = Batzoglou

| first30 = S

| display-authors = 29

| doi = 10.1038/nature06341

| bibcode = 2007Natur.450..203C

| doi-access = free

}}{{Cite journal

| pmid = 18073188

| pmc = 2238844

| year = 2008

| last1 = Wilson

| first1 = D

| title = DBD--taxonomically broad transcription factor predictions: New content and functionality

| journal = Nucleic Acids Research

| volume = 36

| issue = Database issue

| pages = D88–92

| last2 = Charoensawan

| first2 = V

| last3 = Kummerfeld

| first3 = S. K.

| last4 = Teichmann

| first4 = S. A.

| doi = 10.1093/nar/gkm964

}} and protein complex assembly{{Cite book

| pmid = 23663964

| year = 2013

| last1 = Levy

| first1 = E. D.

| title = Oligomerization in Health and Disease

| volume = 117

| pages = 25–51

| last2 = Teichmann

| first2 = S

| doi = 10.1016/B978-0-12-386931-9.00002-7

| chapter = Structural, Evolutionary, and Assembly Principles of Protein Oligomerization

| series = Progress in Molecular Biology and Translational Science

| isbn = 9780123869319

}} using both wet laboratory and computational biology techniques.{{Cite journal | pmid = 25525255| pmc = 4337988| year = 2014| last1 = Perica| first1 = T| title = Evolution of oligomeric state through allosteric pathways that mimic ligand binding| journal = Science| volume = 346| issue = 6216| pages = 1254346| last2 = Kondo| first2 = Y| last3 = Tiwari| first3 = S. P.| last4 = McLaughlin| first4 = S. H.| last5 = Kemplen| first5 = K. R.| last6 = Zhang| first6 = X| last7 = Steward| first7 = A| last8 = Reuter| first8 = N| last9 = Clarke| first9 = J| author-link9 = Jane Clarke (scientist)| last10 = Teichmann| first10 = S. A. | author-link10 = Sarah Teichmann| doi = 10.1126/science.1254346}} In particular her research group:

{{centered pull quote|...seeks to elucidate the principles of protein structure evolution, higher order protein structure and protein folding, and the principles underlying protein complex formation and organization. We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.{{cite web|url=https://www.ebi.ac.uk/research/teichmann|archive-url=https://web.archive.org/web/20130402163004/http://www.ebi.ac.uk/research/teichmann|date=2013|publisher=European Bioinformatics Institute|archive-date=2013-04-02|title=Teichmann group Research EMBL-EBI}}}}

Teichmann's research has been funded by the European Research Council (ERC), the Medical Research Council (MRC), the Biotechnology and Biological Sciences Research Council (BBSRC),{{cite web|url=http://gtr.rcuk.ac.uk/person/E7D7D43E-7A50-4275-A7D7-CBCA7E9D5E16|title= UK Government research grants awarded to Sarah Teichmann|author=Anon|publisher= Research Councils UK|archive-url=https://web.archive.org/web/20150303105747/http://gtr.rcuk.ac.uk/person/E7D7D43E-7A50-4275-A7D7-CBCA7E9D5E16|year=2015|archive-date=2015-03-03}} the Wellcome Trust, the European Molecular Biology Organization (EMBO), the Framework Programmes for Research and Technological Development and the European Cooperation in Science and Technology (COST).

{{As of|2015}} Teichmann has supervised several PhD students to completion{{cite web |url=https://www.ebi.ac.uk/~saraht/people.html |title=Alumni from Sarah Teichmann's Group |last1=Teichmann |first1=Sarah |date=2015 |publisher=European Bioinformatics Institute |archive-date=2024-05-27 |archive-url=https://archive.today/20240527054958/https://www.webcitation.org/6WUCOq6D4?url=https://www.ebi.ac.uk/~saraht/people.html |url-status=dead }} including Madan Babu, Varodom Charoensawan{{cite thesis |degree=PhD |first= Varodom|last=Charoensawan |title=Evolution and dynamics of transcription factors and gene expression patterns |publisher=University of Cambridge |date=2011 |url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609169|oclc= 890150091|website=ethos.bl.uk}} Subhajyoti De{{cite thesis |degree=PhD |first= Subhajyoti|last=De |title=Human genome evolution : investigating protein divergence, polymorphisms and genomic neighbourhood |publisher=University of Cambridge |date=2008|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612500|oclc= 890154864 |website=ethos.bl.uk}} Jay Han,{{cite thesis |degree=PhD |first=Jay|last=Han |title=Structure, function and evolution of protein-protein interactions|publisher=University of Cambridge |date=2007 |url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603640}} Sarah Kay Kummerfeld{{cite thesis |degree=PhD |first= Sarah Kay|last=Kummerfeld |title=Towards understanding the protein universe : genome-scale studies of evolution and gene regulation|publisher=University of Cambridge |date=2006|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613658|website=ethos.bl.uk}}{{cite thesis |degree=PhD|first=Emmanuel Doram|last=Levy|title=Classification, evolution, and assembly of protein complexes|publisher=University of Cambridge|date=2008|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611940|website=ethos.bl.uk}} Tina Perica,{{cite thesis |degree=PhD|first=Tina|last=Perica|title=Evolutionary and structural dynamics of protein complexes |publisher=University of Cambridge|date=2013|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607933|oclc= 890148231}} and Jing Su,{{cite thesis |degree=PhD|first= Jing|last=Su|title=Computational prediction of regulatory elements|publisher=University of Cambridge|date=2012|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610362}} and several postdoctoral researchers who have gone on to become Principal investigators (PIs).{{Cite journal | pmid = 20384991| pmc = 2884543| year = 2010| last1 = Adryan| first1 = B| title = The developmental expression dynamics of Drosophila melanogaster transcription factors| journal = Genome Biology| volume = 11| issue = 4| pages = R40| last2 = Teichmann| first2 = S. A.| doi = 10.1186/gb-2010-11-4-r40| doi-access = free}}{{Cite journal | pmid = 19039133| year = 2008| last1 = Gsponer| first1 = J| title = Tight regulation of unstructured proteins: From transcript synthesis to protein degradation| journal = Science| volume = 322| issue = 5906| pages = 1365–8| last2 = Futschik| first2 = M. E.| last3 = Teichmann| first3 = S. A.| last4 = Babu| first4 = M. M.| doi = 10.1126/science.1163581| pmc = 2803065| bibcode = 2008Sci...322.1365G}}{{Cite journal | pmid = 21131282| pmc = 3061070| year = 2011| last1 = Hebenstreit| first1 = D| title = EpiChIP: Gene-by-gene quantification of epigenetic modification levels| journal = Nucleic Acids Research| volume = 39| issue = 5| pages = e27| last2 = Gu| first2 = M| last3 = Haider| first3 = S| last4 = Turner| first4 = D. J.| last5 = Liò| first5 = P| last6 = Teichmann| first6 = S. A.| doi = 10.1093/nar/gkq1226}}

Teichmann has won a number of awards. In 2010, she was awarded the Colworth Medal from the Biochemical Society.{{cite web |author=Anon |year=2012 |title=Honour and heirloom for Sarah Teichmann |url=http://www2.mrc-lmb.cam.ac.uk/honour-and-heirloom-for-sarah-teichmann/ |archive-url=https://web.archive.org/web/20150303105307/http://www2.mrc-lmb.cam.ac.uk/honour-and-heirloom-for-sarah-teichmann/ |archive-date=2015-03-03 |publisher=Laboratory of Molecular Biology}}{{cite web|url=http://www.cam.ac.uk/women-at-cambridge/profiles/sarah-a-teichmann|title=Women at Cambridge: Sarah Amalia Teichmann|author=Anon|year=2015|publisher=University of Cambridge|archive-url=https://web.archive.org/web/20150220162433/http://www.cam.ac.uk/women-at-cambridge/profiles/sarah-a-teichmann|archive-date=2015-02-20}} In 2012, Teichman was awarded the Francis Crick Medal and Lecture, membership of the European Molecular Biology Organization (EMBO) and the Lister Prize from the Lister Institute of Preventive Medicine. She won the Suffrage Science award in 2012. In 2015 she was awarded the Michael and Kate Bárány Award for young investigators by the Biophysical Society{{cite web|url=http://www.biophysics.org/Portals/1/PDFs/Press%20Room/2014/2015%20Award%20Recipients%20press%20release.pdf|publisher=Biophysical Society|title=Biophysical Society Names 2015 Award Recipients|access-date=8 March 2015|archive-date=4 October 2014|archive-url=https://web.archive.org/web/20141004183808/http://www.biophysics.org/Portals/1/PDFs/Press%20Room/2014/2015%20Award%20Recipients%20press%20release.pdf|url-status=dead}} and the EMBO Gold Medal. Teichmann was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2015. Her citation on election reads: {{centred pull quote|Sarah Teichmann is Research Group Leader at EMBL-European Bioinformatics Institute and has made major contributions to biology over the past 15 years. A fundamental discovery was her work to define key biophysical mechanisms in protein complex assembly, showing that protein complexes assemble via distinct, ordered pathways. She showed that these assembly pathways are conserved in evolution and how they may be predicted from 3D structure. Her databases and computational analysis methods have had a broad and deep impact on the community. She represents a new breed of scientists at the interface between computational and experimental molecular biology.{{cite web|author=Anon|year=2015|archive-url=https://web.archive.org/web/20150706123113/http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/dr-sarah-teichmann/|archive-date=2015-07-06|website=acmedsci.ac.uk|url=http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/dr-sarah-teichmann/|title=Dr Sarah Teichmann FMedSci|publisher=Academy of Medical Sciences|location=London}}}}

Teichmann has also been an activist for women's careers in science through enabling scientists in families to advance their careers while working part-time.{{cite web|last1=Gaskell & Kostic|title=The Unstoppable Sarah Teichmann on Programing, Motherhood, and Protein Complex Assembly:The Female Scientist|url=http://www.cell.com/crosstalk/sarah-teichmann-on-programming-motherhood-and-complex-assembly|website=Cell|year=2015|access-date=2015-11-25|archive-url=https://web.archive.org/web/20160402112200/http://crosstalk.cell.com/blog/sarah-teichmann-on-programming-motherhood-and-complex-assembly|archive-date=2016-04-02|url-status=dead}} She chaired a Sex in Science debate at the Wellcome Trust on balancing family life with working in research.{{citation needed|date=April 2016}} Teichmann was elected an ISCB Fellow in 2016 by the International Society for Computational Biology.{{cite web|archive-url=https://web.archive.org/web/20170320114530/https://www.iscb.org/iscb-fellows|archive-date=2017-03-20|url=https://www.iscb.org/iscb-fellows|website=iscb.org|title=ISCB Fellows|publisher=International Society for Computational Biology|author=Anon|year=2017}}

In 2020, Teichmann was recognised on The Times 'Science Power List' for her work on the Human Cell Atlas{{Cite news|last=Franklin-Wallis|first=Oliver|date=23 May 2020|title=From pandemics to cancer: the science power list|language=en|work=The Times|url=https://www.thetimes.com/uk/healthcare/article/from-pandemics-to-cancer-the-science-power-list-d23bb9b2k|access-date=2020-05-26|issn=0140-0460}} and elected a Fellow of the Royal Society.{{cite web|url=https://royalsociety.org/people/sarah-teichmann-25293/|title=Sarah Teichmann|publisher=Royal Society|access-date= 20 September 2020}}

In 2023 Teichmann was the winner of the Federation of European Biochemical Societies (FEBS) EMBO Women in Science Award.{{Cite web |date=2022-08-26 |title=FEBS {{!}} EMBO Women in Science Award - FEBS |url=https://www.febs.org/other-activities/prizes/febs-embo-women-in-science-award/ |access-date=2024-01-04 |language=en-GB}}

Teichmann has two daughters.{{cite journal|last1=Pain|first1=Elisabeth|title=Harnessing computer power to understand biology|journal=Science|year=2015|doi=10.1126/science.caredit.a1500172}} Teichmann is the co-author of the children's language education novel Teenage Detectives,{{Cite book|title = Cornelsen English Library - Fiction: 8. Schuljahr, Stufe 1 - Teenage Detectives: Textheft. Mit Aufgaben und Activities|last1 = Teichmann|first1 = Sarah|publisher = Cornelsen Verlag|year = 1991|isbn = 978-3464053362|location = Germany|last2 = Teichmann|first2 = Virginia}} which she wrote as a teenager together with her mother Dr. Virginia Teichmann, an English-language university lecturer in Karlsruhe.{{Cite web|url = http://www.expat-karlsruhe.com/uploads/media/Honeycomb-Issue1.pdf|title = The Honeycomb: Dr. Virginia Teichmann: Word Lover|access-date = 2015-12-07|website =expat-karlsruhe.com |author=Anon }} In 2022, Teichmann collaborated in the production of an experimental film Constellations, which was produced by her sister, artist Esther Teichmann, and visual artist Christopher Stewart as an exploration of the Human Cell Atlas. The film was funded by the Wellcome Trust as part of the One Cell at a Time public engagement grant.{{Cite web |title=Constellations – One Cell at a Time |url=https://www.onecellatatime.org/exhibits/constellations/ |access-date=2025-03-28 |website=www.onecellatatime.org}}{{Cite web |title=Tank Magazine |url=https://magazine.tank.tv/tank/2022/07/constellations |access-date=2025-03-28 |website=Tank Magazine |language=en-gb}}

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Category:1975 births

Category:Living people

Category:German bioinformaticians

Category:Wellcome Trust

Category:Fellows of Churchill College, Cambridge

Category:Fellows of Trinity College, Cambridge

Category:Alumni of University College London

Category:Members of the European Molecular Biology Organization

Category:Fellows of the Academy of Medical Sciences (United Kingdom)

Category:Fellows of the International Society for Computational Biology

Category:Alumni of the European Schools

Category:German women scientists

Category:Female fellows of the Royal Society