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Sialidase-2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.{{cite journal |vauthors=Monti E, Preti A, Rossi E, Ballabio A, Borsani G | title = Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases | journal = Genomics | volume = 57 | issue = 1 | pages = 137–143 |date=Jun 1999 | pmid = 10191093 | doi = 10.1006/geno.1999.5749 }}{{cite journal |vauthors=Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E | title = Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules | journal = J Biol Chem | volume = 279 | issue = 5 | pages = 3169–3179 |date=Jan 2004 | pmid = 14613940 | doi = 10.1074/jbc.M308381200 | doi-access = free }}{{cite web | title = Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4759}}

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS-7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.

References

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Further reading

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  • {{cite journal | author=Li CY |title=A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir |journal=Cell Res. |volume=17 |issue= 4 |pages= 357–362 |year= 2007 |pmid= 17426694 |doi= 10.1038/cr.2007.27 | author2=Yu Q | author3=Ye ZQ | last4=Sun | first4=Ying | last5=He | first5=Quanyuan | last6=Li | first6=Xiao-Mo | last7=Zhang | first7=Wuxue | last8=Luo | first8=Jingchu | last9=Gu | first9=Xiaocheng | doi-access=free }}
  • {{cite journal | author=Chavas LM |title=Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition |journal=J. Biol. Chem. |volume=280 |issue= 1 |pages= 469–75 |year= 2005 |pmid= 15501818 |doi= 10.1074/jbc.M411506200 | author2=Tringali C | author3=Fusi P | last4=Venerando | first4=B | last5=Tettamanti | first5=G | last6=Kato | first6=R | last7=Monti | first7=E | last8=Wakatsuki | first8=S | doi-access= free}}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Hart ML |title=High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1 |journal=AIDS Res. Hum. Retroviruses |volume=18 |issue= 17 |pages= 1311–1317 |year= 2003 |pmid= 12487819 |doi= 10.1089/088922202320886352 | author2=Saifuddin M | author3=Uemura K | last4=Bremer | first4=Eric G. | last5=Hooker | first5=Brad | last6=Kawasaki | first6=Toshisuke | last7=Spear | first7=Gregory T. }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Bassi MT |title=SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family |journal=Genomics |volume=62 |issue= 2 |pages= 297–303 |year= 2000 |pmid= 10610726 |doi= 10.1006/geno.1999.5978 | author2=Sperandeo MP | author3=Incerti B | last4=Bulfone | first4=A | last5=Pepe | first5=A | last6=Surace | first6=EM | last7=Gattuso | first7=C | last8=De Grandi | first8=A | last9=Buoninconti | first9=A }}
  • {{cite journal | author=Monti E |title=Expression of a novel human sialidase encoded by the NEU2 gene |journal=Glycobiology |volume=9 |issue= 12 |pages= 1313–1321 |year= 2000 |pmid= 10561456 |doi=10.1093/glycob/9.12.1313 | author2=Preti A | author3=Nesti C | last4=Ballabio | first4=A | last5=Borsani | first5=G |doi-access=free}}
  • {{cite journal | author=Hu H |title=Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface |journal=J. Virol. |volume=70 |issue= 11 |pages= 7462–70 |year= 1996 |pmid= 8892864 |doi= 10.1128/JVI.70.11.7462-7470.1996| pmc=190813 | author2=Shioda T | author3=Moriya C | last4=Xin | first4=X | last5=Hasan | first5=MK | last6=Miyake | first6=K | last7=Shimada | first7=T | last8=Nagai | first8=Y }}
  • {{cite journal | author=Miyagi T |title=Molecular cloning and expression of cDNA encoding rat skeletal muscle cytosolic sialidase |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26435–40 |year= 1994 |pmid= 8253770 | author2=Konno K | author3=Emori Y | last4=Kawasaki | first4=H | last5=Suzuki | first5=K | last6=Yasui | first6=A | last7=Tsuik | first7=S |doi=10.1016/S0021-9258(19)74333-6 |doi-access=free }}

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External links

  • [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q9Y3R4 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Sialidase-2

{{PDB Gallery|geneid=4759}}

{{Sugar hydrolases}}

Category:Human proteins

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