Small nucleolar RNA SNORD24

{{Infobox rfam

| Name = Small nucleolar RNA SNORD24

| image = RF00069.jpg

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| caption = Predicted secondary structure and sequence conservation of SNORD24

| Symbol = SNORD24

| AltSymbols = U24

| Rfam = RF00069

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| RNA_type = Gene; snRNA; snoRNA; C/D-box

| Tax_domain = Eukaryota

| GO = {{GO|0006396}} {{GO|0005730}}

| SO = {{SO|0000593}}

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In molecular biology, U24 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs.{{cite journal | vauthors = Qu LH, Henry Y, Nicoloso M, Michot B, Azum MC, Renalier MH, Caizergues-Ferrer M, Bachellerie JP | title = U24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementarities to 28S rRNA | journal = Nucleic Acids Research | volume = 23 | issue = 14 | pages = 2669–76 | date = July 1995 | pmid = 7651828 | pmc = 307091 | doi = 10.1093/nar/23.14.2669 }} C/D box snoRNAs have been shown to act as methylation guides for a number of RNA targets.{{cite journal | vauthors = Nicoloso M, Qu LH, Michot B, Bachellerie JP | title = Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs | journal = Journal of Molecular Biology | volume = 260 | issue = 2 | pages = 178–95 | date = July 1996 | pmid = 8764399 | doi = 10.1006/jmbi.1996.0391 }}{{cite journal | vauthors = Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T | title = Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs | journal = Cell | volume = 85 | issue = 7 | pages = 1077–88 | date = June 1996 | pmid = 8674114 | doi = 10.1016/S0092-8674(00)81308-2 | s2cid = 10418885 | doi-access = free }} U24 is encoded within an intron of the gene for ribosomal protein L7a in mammals, chicken and Fugu.{{cite journal | vauthors = Gilley J, Fried M | title = Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants | journal = DNA and Cell Biology | volume = 17 | issue = 7 | pages = 591–602 | date = July 1998 | pmid = 9703018 | doi = 10.1089/dna.1998.17.591 }} The U76/SNORD76 snoRNA is found in an intron of the uRNA host gene (UHG) growth arrest specific 5 (GAS5) transcript gene.{{cite journal | vauthors = Hirose T, Steitz JA | title = Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 23 | pages = 12914–9 | date = November 2001 | pmid = 11606788 | pmc = 60799 | doi = 10.1073/pnas.231490998 | jstor = 3057015 | bibcode = 2001PNAS...9812914H | doi-access = free }} snoRNAs Z20 and U76 snoRNAs show clear similarity to U24.

An experiment that looked at 22 different non-small-cell lung cancer tissues found that SNORD33, SNORD66 and SNORD76 were over-expressed relative to matched noncancerous lung tissues.{{cite journal | vauthors = Liao J, Yu L, Mei Y, Guarnera M, Shen J, Li R, Liu Z, Jiang F | title = Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer | journal = Molecular Cancer | volume = 9 | pages = 198 | date = July 2010 | pmid = 20663213 | pmc = 2919450 | doi = 10.1186/1476-4598-9-198 | doi-access = free }}