TAS2R4

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. The geographic distribution of TAS2R4 and TAS2R5 missense allele variants which prevent expression of the receptors is aligned with the distributions of tannin sorghum and the destructive agricultural bird pest in Africa, indicating the role of human taste in developing agroecosystems fitting local environments.{{cite journal | vauthors = Wu Y, Guo T, Mu Q, Wang J, Li X, Wu Y, Tian B, Wang ML, Bai G, Perumal R, Trick HN, Bean SR, Dweikat IM, Tuinstra MR, Morris G, Tesso TT, Yu J, Li X | display-authors = 6 | title = Allelochemicals targeted to balance competing selections in African agroecosystems | journal = Nature Plants | volume = 5 | issue = 12 | pages = 1229–1236 | date = December 2019 | pmid = 31792396 | doi = 10.1038/s41477-019-0563-0 | s2cid = 208539527 | url = http://www.nature.com/articles/s41477-019-0563-0 | url-access = subscription }}

Ligands listed in BitterDB include quinine, parthenolide, denatonium, some non-sugar sweeteners including sucralose and stevioside, and several oligopeptides.{{BitterDB receptor|id=4|title=hTAS2R4 - Taste receptor type 2 member 4}}

• Taste receptor

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• {{cite journal | vauthors = Kinnamon SC | title = A plethora of taste receptors | journal = Neuron | volume = 25 | issue = 3 | pages = 507–10 | date = March 2000 | pmid = 10774719 | doi = 10.1016/S0896-6273(00)81054-5 | doi-access = free }}
• {{cite journal | vauthors = Margolskee RF | title = Molecular mechanisms of bitter and sweet taste transduction | journal = The Journal of Biological Chemistry | volume = 277 | issue = 1 | pages = 1–4 | date = January 2002 | pmid = 11696554 | doi = 10.1074/jbc.R100054200 | doi-access = free }}
• {{cite journal | vauthors = Montmayeur JP, Matsunami H | title = Receptors for bitter and sweet taste | journal = Current Opinion in Neurobiology | volume = 12 | issue = 4 | pages = 366–71 | date = August 2002 | pmid = 12139982 | doi = 10.1016/S0959-4388(02)00345-8 | s2cid = 37807140 }}
• {{cite journal | vauthors = Firestein S | title = The good taste of genomics | journal = Nature | volume = 404 | issue = 6778 | pages = 552–3 | date = April 2000 | pmid = 10766221 | doi = 10.1038/35007167 | s2cid = 35741332 | doi-access = free }}
• {{cite journal | vauthors = Matsunami H, Montmayeur JP, Buck LB | title = A family of candidate taste receptors in human and mouse | journal = Nature | volume = 404 | issue = 6778 | pages = 601–4 | date = April 2000 | pmid = 10766242 | doi = 10.1038/35007072 | bibcode = 2000Natur.404..601M | s2cid = 4336913 }}
• {{cite journal | vauthors = Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S | title = Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting | journal = Biochemical and Biophysical Research Communications | volume = 285 | issue = 1 | pages = 147–51 | date = July 2001 | pmid = 11437385 | doi = 10.1006/bbrc.2001.5136 }}
• {{cite journal | vauthors = Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ | display-authors = 6 | title = Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways | journal = Cell | volume = 112 | issue = 3 | pages = 293–301 | date = February 2003 | pmid = 12581520 | doi = 10.1016/S0092-8674(03)00071-0 | s2cid = 718601 | doi-access = free }}
• {{cite journal | vauthors = Fischer A, Gilad Y, Man O, Pääbo S | title = Evolution of bitter taste receptors in humans and apes | journal = Molecular Biology and Evolution | volume = 22 | issue = 3 | pages = 432–6 | date = March 2005 | pmid = 15496549 | doi = 10.1093/molbev/msi027 | doi-access = free }}
• {{cite journal | vauthors = Go Y, Satta Y, Takenaka O, Takahata N | title = Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates | journal = Genetics | volume = 170 | issue = 1 | pages = 313–26 | date = May 2005 | pmid = 15744053 | pmc = 1449719 | doi = 10.1534/genetics.104.037523 }}

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{{G protein-coupled receptors|g3}}

Category:Human taste receptors

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