TFB1M
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial enzyme that is encoded by the TFB1M gene.{{cite journal |vauthors=Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Res | volume = 10 | issue = 5 | pages = 703–13 |date=Aug 2000 | pmid = 10810093 | pmc = 310876 | doi =10.1101/gr.10.5.703 }}{{cite journal |vauthors=McCulloch V, Seidel-Rogol BL, Shadel GS | title = A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine | journal = Mol Cell Biol | volume = 22 | issue = 4 | pages = 1116–25 |date=Jan 2002 | pmid = 11809803 | pmc = 134642 | doi =10.1128/MCB.22.4.1116-1125.2002 }}{{cite web | title = Entrez Gene: TFB1M transcription factor B1, mitochondrial| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51106| accessdate = }}
TFB1M is a mitochondrial methyltransferase, which uses S-adenosyl methionine to dimethylate two highly conserved adenosine residues at the 3'-end of the mitochondrial 12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.{{cite journal |authorlink1=Maria Falkenberg |vauthors=Falkenberg M, Gaspari M, Rantanen A, etal |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 |s2cid=11164308 }}{{cite journal |author1=Metodiev MD |author2=Lesko N |author3=Park CB |author4=Camara Y. |author5=Shi Y. |author6=Wibom R. |author7=Hultenby K. |author8=Gustafsson CM |author9=Larsson NG. | title = Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome | journal = Cell Metab. | volume = 9 | issue = 4 | pages = 386–97 |date=Apr 2009 | pmid = 19356719 | doi =10.1016/j.cmet.2009.03.001|doi-access=free }}
Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an in vitro system containing recombinant mitochondrial RNA polymerase and TFAM.{{cite journal |vauthors=Falkenberg M, Gaspari M, Rantanen A, etal |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 |s2cid=11164308 }} There are no experimental data demonstrating that this function occurs in vivo; the paralogous TFB2M is more specific for this role.{{cite journal |last1=Hillen |first1=HS |last2=Morozov |first2=YI |last3=Sarfallah |first3=A |last4=Temiakov |first4=D |last5=Cramer |first5=P |title=Structural Basis of Mitochondrial Transcription Initiation. |journal=Cell |date=16 November 2017 |volume=171 |issue=5 |pages=1072–1081.e10 |doi=10.1016/j.cell.2017.10.036 |pmid=29149603|pmc=6590061 }}
Interactions
TFB1M has been shown to interact with TFAM.{{cite journal |doi=10.1128/MCB.23.16.5816-5824.2003 |last=McCulloch |first=Vicki |author2=Shadel Gerald S |date=Aug 2003 |title=Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity |journal=Mol. Cell. Biol. |volume=23 |issue=16 |pages=5816–24 | issn = 0270-7306| pmid = 12897151 |pmc=166325 }}
References
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Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Falkenberg M, Gaspari M, Rantanen A, etal |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 |s2cid=11164308 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Seidel-Rogol BL, McCulloch V, Shadel GS |title=Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. |journal=Nat. Genet. |volume=33 |issue= 1 |pages= 23–4 |year= 2003 |pmid= 12496758 |doi= 10.1038/ng1064 |s2cid=169443 }}
- {{cite journal |vauthors=Rantanen A, Gaspari M, Falkenberg M, etal |title=Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. |journal=Mamm. Genome |volume=14 |issue= 1 |pages= 1–6 |year= 2003 |pmid= 12532263 |doi= 10.1007/s00335-002-2218-z |s2cid=25379746 }}
- {{cite journal |vauthors=McCulloch V, Shadel GS |title=Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. |journal=Mol. Cell. Biol. |volume=23 |issue= 16 |pages= 5816–24 |year= 2003 |pmid= 12897151 |doi=10.1128/MCB.23.16.5816-5824.2003 | pmc=166325 }}
- {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |doi-access= free |bibcode= 2003Natur.425..805M }}
- {{cite journal |vauthors=Bykhovskaya Y, Mengesha E, Wang D, etal |title=Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation. |journal=Mol. Genet. Metab. |volume=82 |issue= 1 |pages= 27–32 |year= 2004 |pmid= 15110318 |doi= 10.1016/j.ymgme.2004.01.020 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Gleyzer N, Vercauteren K, Scarpulla RC |title=Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. |journal=Mol. Cell. Biol. |volume=25 |issue= 4 |pages= 1354–66 |year= 2005 |pmid= 15684387 |doi= 10.1128/MCB.25.4.1354-1366.2005 | pmc=548005 }}
- {{cite journal |vauthors=Cotney J, Wang Z, Shadel GS |title=Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression. |journal=Nucleic Acids Res. |volume=35 |issue= 12 |pages= 4042–54 |year= 2007 |pmid= 17557812 |doi= 10.1093/nar/gkm424 | pmc=1919481 }}
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