TGF-beta receptor family#Type I

TGFβ family receptors are grouped into three types, type I, type II, and type III. There are seven type I receptors, termed the activin-like receptors (ALK1–7), five type II receptors, and one type III receptor, for a total of 13 TGFβ superfamily receptors.{{cite book | first1 = Steven J. | last1 = Fliesler | first2 = Oleg G. | last2 = Kisselev | name-list-style = vanc | title = Signal Transduction in the Retina|url=https://books.google.com/books?id=frEQu0Hc6scC&pg=PA273|date=26 December 2007|publisher=CRC Press|isbn=978-1-4200-0716-9|pages=273–}}{{cite book | first = Marc | last = Thiriet | name-list-style = vanc | title = Signaling at the Cell Surface in the Circulatory and Ventilatory Systems|url=https://books.google.com/books?id=MF_kmIWZRrMC&pg=PA666|date=14 December 2011|publisher=Springer Science & Business Media|isbn=978-1-4614-1991-4|pages=666–}} In the transduction pathway, ligand-bound type II receptors activate type I receptors by phosphorylation, which then autophosphorylate and bind SMAD.{{cite journal

|vauthors=Wrana JL, Attisano L, Cárcamo J, etal |title=TGF beta signals through a heteromeric protein kinase receptor complex |journal=Cell |volume=71 |issue=6 |pages=1003–14 |date=December 1992 |pmid=1333888 |doi= 10.1016/0092-8674(92)90395-S|s2cid=54397586 }} The Type I receptors have a glycine-serine (GS, or TTSGSGSG) repeat motif of around 30 AA, a target of type II activity. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.{{cite journal |last1=Huse |first1=M |last2=Muir |first2=TW |last3=Xu |first3=L |last4=Chen |first4=YG |last5=Kuriyan |first5=J |last6=Massagué |first6=J |title=The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. |journal=Molecular Cell |date=September 2001 |volume=8 |issue=3 |pages=671–82 |pmid=11583628|doi=10.1016/S1097-2765(01)00332-X |doi-access=free }}

{{Infobox protein family

|Pfam=PF08515

|Name=Transforming growth factor beta type I GS-motif

|Symbol= TGF_beta_GS

|InterPro=IPR003605

}}

• ALK1 (ACVRL1)
• ALK2 (ACVR1A)
• ALK3 (BMPR1A)
• ALK4 (ACVR1B)
• ALK5 (TGFβR1)
• ALK6 (BMPR1B)
• ALK7 (ACVR1C)

• TGFβR2
• BMPR2
• ACVR2A
• ACVR2B
• AMHR2 (AMHR)

Unlike the Type I and II receptors which are kinases, TGFBR3 has a Zona pellucida-like domain. Its core domain binds TGF-beta family ligands and its heparan sulfate chains bind bFGF. It acts as a reservoir of ligand for TGF-beta receptors.{{cite journal |vauthors=Andres JL, Stanley K, etal | title= Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta | journal= J. Cell Biol. | year=1989 | volume=109 | issue=6 (Pt 1) | pages= 3137–3145 | pmid = 2592419 | doi= 10.1083/jcb.109.6.3137 | pmc= 2115961}}{{cite journal |vauthors=Andres JL, DeFalcis D, etal | title= Binding of two growth factor families to separate domains of the proteoglycan betaglycan | journal= J. Biol. Chem. | year=1992 | volume=267 | issue=9 | pages=5927–5930 | doi= 10.1016/S0021-9258(18)42643-9 | pmid =1556106 | doi-access= free }}

• TGFβR3 (β-glycan)

{{Reflist|2}}

{{TGF beta signaling}}

{{Growth factor receptors}}

{{Cytokine receptors}}

{{Enzyme-linked receptors}}

{{Serine/threonine-specific protein kinases}}

{{TGFβ receptor superfamily modulators}}

{{Portal bar|Biology|border=no}}

{{DEFAULTSORT:TGFss superfamily receptor}}

Category:TGF beta receptors

Category:Transmembrane receptors

Category:Protein families

{{receptor-stub}}