TGS1
{{cs1 config|name-list-style=vanc}}
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.{{cite journal | vauthors = Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK | title = Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 18 | pages = 10380–5 | date = Aug 2001 | pmid = 11517327 | pmc = 56969 | doi = 10.1073/pnas.181347498 | bibcode = 2001PNAS...9810380Z | doi-access = free }}{{cite journal | vauthors = Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonné R | title = Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus | journal = Mol Cell | volume = 9 | issue = 4 | pages = 891–901 | date = May 2002 | pmid = 11983179 | doi = 10.1016/S1097-2765(02)00484-7 | doi-access = free }}{{cite web | title = Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=96764}}
Interactions
TGS1 has been shown to interact with:
- CREB-binding protein, and
- EED,{{cite journal | vauthors = Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I | title = Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus | journal = Biochem. Biophys. Res. Commun. | volume = 309 | issue = 1 | pages = 44–51 | date = Sep 2003 | pmid = 12943661 | doi = 10.1016/s0006-291x(03)01514-6}}
- EP300,
- MED1, and
- NCOA6.{{cite journal | vauthors = Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK | title = Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 20011–9 | date = May 2002 | pmid = 11912212 | doi = 10.1074/jbc.M201739200 | doi-access = free}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK | title = Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 20011–9 | year = 2002 | pmid = 11912212 | doi = 10.1074/jbc.M201739200 | doi-access = free}}
- {{cite journal | vauthors = Verheggen C, Lafontaine DL, Samarsky D, Mouaikel J, Blanchard JM, Bordonné R, Bertrand E | title = Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments | journal = EMBO J. | volume = 21 | issue = 11 | pages = 2736–45 | year = 2002 | pmid = 12032086 | pmc = 126019 | doi = 10.1093/emboj/21.11.2736 }}
- {{cite journal | vauthors = Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF | title = Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies | journal = J. Immunol. | volume = 169 | issue = 2 | pages = 1102–9 | year = 2002 | pmid = 12097419 | doi = 10.4049/jimmunol.169.2.1102 | doi-access = free }}
- {{cite journal | vauthors = Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, Reddy JK | title = Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 18 | pages = 11836–41 | year = 2002 | pmid = 12189208 | pmc = 129355 | doi = 10.1073/pnas.182426699 | bibcode = 2002PNAS...9911836S | doi-access = free }}
- {{cite journal | vauthors = Krackhardt AM, Witzens M, Harig S, Hodi FS, Zauls AJ, Chessia M, Barrett P, Gribben JG | title = Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX | journal = Blood | volume = 100 | issue = 6 | pages = 2123–31 | year = 2002 | pmid = 12200376 | doi = 10.1182/blood-2002-02-0513 | doi-access = free }}
- {{cite journal | vauthors = Mouaikel J, Narayanan U, Verheggen C, Matera AG, Bertrand E, Tazi J, Bordonné R | title = Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron | journal = EMBO Rep. | volume = 4 | issue = 6 | pages = 616–22 | year = 2004 | pmid = 12776181 | pmc = 1319203 | doi = 10.1038/sj.embor.embor863 }}
- {{cite journal | vauthors = Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I | title = Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus | journal = Biochem. Biophys. Res. Commun. | volume = 309 | issue = 1 | pages = 44–51 | year = 2003 | pmid = 12943661 | doi = 10.1016/S0006-291X(03)01514-6 }}
- {{cite journal | vauthors = Watkins NJ, Lemm I, Ingelfinger D, Schneider C, Hossbach M, Urlaub H, Lührmann R | title = Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex | journal = Mol. Cell | volume = 16 | issue = 5 | pages = 789–98 | year = 2005 | pmid = 15574333 | doi = 10.1016/j.molcel.2004.11.012 | hdl = 11858/00-001M-0000-0012-EB89-8 | hdl-access = free }}
- {{cite journal | vauthors = Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mamm. Genome | volume = 16 | issue = 12 | pages = 942–54 | year = 2006 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 | s2cid = 69278 }}
{{refend}}
{{gene-8-stub}}