NCOA6

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D₃, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.

NCOA6 has been shown to interact with:

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• ASCL2 and
• Activating transcription factor 2,{{cite journal | vauthors = Hong S, Choi HM, Park MJ, Kim YH, Choi YH, Kim HH, Choi YH, Cheong J | title = Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid | journal = J. Biol. Chem. | volume = 279 | issue = 17 | pages = 16996–7003 | date = April 2004 | pmid = 14734562 | doi = 10.1074/jbc.M311752200 | doi-access = free }}
• Androgen receptor,
• CREB-binding protein,{{cite journal | vauthors = Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW | title = A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo | journal = J. Biol. Chem. | volume = 274 | issue = 48 | pages = 34283–93 | date = November 1999 | pmid = 10567404 | doi = 10.1074/jbc.274.48.34283 | doi-access = free }}{{cite journal | vauthors = Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW | title = Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2 | journal = Mol. Endocrinol. | volume = 15 | issue = 2 | pages = 241–54 | date = February 2001 | pmid = 11158331 | doi = 10.1210/mend.15.2.0595 | doi-access = free }}
• DNA-PKcs,
• E2F1,{{cite journal | vauthors = Kong HJ, Yu HJ, Hong S, Park MJ, Choi YH, An WG, Lee JW, Cheong J | title = Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation | journal = Mol. Cancer Res. | volume = 1 | issue = 13 | pages = 948–58 | date = November 2003 | pmid = 14638867 }}
• EP300,
• Estrogen receptor alpha,
• Estrogen receptor beta,
• HBXIP,{{cite journal | vauthors = Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J | title = Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2 | journal = Hepatology | volume = 38 | issue = 5 | pages = 1258–66 | date = November 2003 | pmid = 14578865 | doi = 10.1053/jhep.2003.50451 | s2cid = 29349615 | doi-access = free }}
• HIST2H3C,
• HSF1,{{cite journal | vauthors = Hong S, Kim SH, Heo MA, Choi YH, Park MJ, Yoo MA, Kim HD, Kang HS, Cheong J | title = Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock | journal = FEBS Lett. | volume = 559 | issue = 1–3 | pages = 165–70 | date = February 2004 | pmid = 14960326 | doi = 10.1016/S0014-5793(04)00028-6 | s2cid = 22383479 | doi-access = free | bibcode = 2004FEBSL.559..165H }}
• Ku70,{{cite journal | vauthors = Ko L, Cardona GR, Chin WW | title = Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 11 | pages = 6212–7 | date = May 2000 | pmid = 10823961 | pmc = 18584 | doi = 10.1073/pnas.97.11.6212 | bibcode = 2000PNAS...97.6212K | doi-access = free }}{{cite journal | vauthors = Ko L, Chin WW | title = Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase | journal = J. Biol. Chem. | volume = 278 | issue = 13 | pages = 11471–9 | date = March 2003 | pmid = 12519782 | doi = 10.1074/jbc.M209723200 | doi-access = free }}
• Ku80,
• Liver X receptor beta,
• MLL3,
• RBBP5,{{cite journal | vauthors = Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW | title = Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins | journal = Mol. Cell. Biol. | volume = 23 | issue = 1 | pages = 140–9 | date = January 2003 | pmid = 12482968 | pmc = 140670 | doi = 10.1128/mcb.23.1.140-149.2003 }}
• Retinoblastoma protein,{{cite journal | vauthors = Goo YH, Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW | title = Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation | journal = J. Biol. Chem. | volume = 279 | issue = 8 | pages = 7131–5 | date = February 2004 | pmid = 14645241 | doi = 10.1074/jbc.M312563200 | doi-access = free }}
• Retinoic acid receptor alpha,
• Retinoid X receptor alpha,
• Src,{{cite journal | vauthors = Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW | title = Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2 | journal = Mol. Endocrinol. | volume = 14 | issue = 6 | pages = 915–25 | date = June 2000 | pmid = 10847592 | doi = 10.1210/mend.14.6.0471 | doi-access = free }}
• TGS1,{{cite journal | vauthors = Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK | title = Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 20011–9 | date = May 2002 | pmid = 11912212 | doi = 10.1074/jbc.M201739200 | doi-access = free}}{{cite journal | vauthors = Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK | title = Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 18 | pages = 10380–5 | date = August 2001 | pmid = 11517327 | pmc = 56969 | doi = 10.1073/pnas.181347498 | bibcode = 2001PNAS...9810380Z | doi-access = free }}
• TUBA4A,
• TUBB,
• Thyroid hormone receptor alpha, and
• Thyroid hormone receptor beta.{{cite journal | vauthors = Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW | title = Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs | journal = Mol. Endocrinol. | volume = 16 | issue = 1 | pages = 128–40 | date = January 2002 | pmid = 11773444 | doi = 10.1210/mend.16.1.0755 | doi-access = free }}

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• Transcription coregulator

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{{reflist|35em}}

{{refbegin|35em}}

• {{cite journal | vauthors = Mahajan MA, Samuels HH | title = A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein | journal = Mol. Cell. Biol. | volume = 20 | issue = 14 | pages = 5048–63 | date = July 2000 | pmid = 10866662 | pmc = 85955 | doi = 10.1128/MCB.20.14.5048-5063.2000 }}
• {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2003 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 | doi-access = free }}
• {{cite journal | vauthors = Carney JP, McKnight C, VanEpps S, Kelley MR | title = Random rapid amplification of cDNA ends (RRACE) allows for cloning of multiple novel human cDNA fragments containing (CAG)n repeats | journal = Gene | volume = 155 | issue = 2 | pages = 289–92 | year = 1995 | pmid = 7536696 | doi = 10.1016/0378-1119(94)00758-K }}
• {{cite journal | vauthors = Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS | title = Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer | journal = Cancer Res. | volume = 56 | issue = 15 | pages = 3446–50 | year = 1996 | pmid = 8758910 }}
• {{cite journal | vauthors = Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW | title = A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo | journal = J. Biol. Chem. | volume = 274 | issue = 48 | pages = 34283–93 | year = 1999 | pmid = 10567404 | doi = 10.1074/jbc.274.48.34283 | doi-access = free }}
• {{cite journal | vauthors = Caira F, Antonson P, Pelto-Huikko M, Treuter E, Gustafsson JA | title = Cloning and characterization of RAP250, a novel nuclear receptor coactivator | journal = J. Biol. Chem. | volume = 275 | issue = 8 | pages = 5308–17 | year = 2000 | pmid = 10681503 | doi = 10.1074/jbc.275.8.5308 | doi-access = free }}
• {{cite journal | vauthors = Zhu Y, Kan L, Qi C, Kanwar YS, Yeldandi AV, Rao MS, Reddy JK | title = Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR | journal = J. Biol. Chem. | volume = 275 | issue = 18 | pages = 13510–6 | year = 2000 | pmid = 10788465 | doi = 10.1074/jbc.275.18.13510 | doi-access = free }}
• {{cite journal | vauthors = Ko L, Cardona GR, Chin WW | title = Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 11 | pages = 6212–7 | year = 2000 | pmid = 10823961 | pmc = 18584 | doi = 10.1073/pnas.97.11.6212 | bibcode = 2000PNAS...97.6212K | doi-access = free }}
• {{cite journal | vauthors = Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW | title = Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2 | journal = Mol. Endocrinol. | volume = 14 | issue = 6 | pages = 915–25 | year = 2000 | pmid = 10847592 | doi = 10.1210/mend.14.6.0471 | doi-access = free }}
• {{cite journal | vauthors = Mahajan MA, Samuels HH | title = A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein | journal = Mol. Cell. Biol. | volume = 20 | issue = 14 | pages = 5048–63 | year = 2000 | pmid = 10866662 | pmc = 85955 | doi = 10.1128/MCB.20.14.5048-5063.2000 }}
• {{cite journal | vauthors = Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW | title = Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2 | journal = Mol. Endocrinol. | volume = 15 | issue = 2 | pages = 241–54 | year = 2001 | pmid = 11158331 | doi = 10.1210/mend.15.2.0595 | doi-access = free }}
• {{cite journal | vauthors = Hong S, Lee MY, Cheong J | title = Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell | journal = Biochem. Biophys. Res. Commun. | volume = 282 | issue = 5 | pages = 1257–62 | year = 2001 | pmid = 11302752 | doi = 10.1006/bbrc.2001.4727 }}
• {{cite journal | vauthors = Iwasaki T, Chin WW, Ko L | title = Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM) | journal = J. Biol. Chem. | volume = 276 | issue = 36 | pages = 33375–83 | year = 2001 | pmid = 11443112 | doi = 10.1074/jbc.M101517200 | doi-access = free }}
• {{cite journal | vauthors = Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK | title = Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 18 | pages = 10380–5 | year = 2001 | pmid = 11517327 | pmc = 56969 | doi = 10.1073/pnas.181347498 | bibcode = 2001PNAS...9810380Z | doi-access = free }}
• {{cite journal | vauthors = Jung DJ, Na SY, Na DS, Lee JW | title = Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors | journal = J. Biol. Chem. | volume = 277 | issue = 2 | pages = 1229–34 | year = 2002 | pmid = 11704680 | doi = 10.1074/jbc.M110417200 | doi-access = free }}
• {{cite journal | vauthors = Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW | title = Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs | journal = Mol. Endocrinol. | volume = 16 | issue = 1 | pages = 128–40 | year = 2002 | pmid = 11773444 | doi = 10.1210/mend.16.1.0755 | doi-access = free }}
• {{cite journal | vauthors = Qi C, Chang J, Zhu Y, Yeldandi AV, Rao SM, Zhu YJ | title = Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha | journal = J. Biol. Chem. | volume = 277 | issue = 32 | pages = 28624–30 | year = 2002 | pmid = 12039952 | doi = 10.1074/jbc.M201053200 | doi-access = free }}
• {{cite journal | vauthors = Espejo F, Green M, Preece NE, Assa-Munt N | title = NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation | journal = J. Biomol. NMR | volume = 23 | issue = 2 | pages = 151–2 | year = 2003 | pmid = 12153040 | doi = 10.1023/A:1016398403157 | s2cid = 40822239 }}

{{refend}}

• {{MeshName|NCOA6+protein,+human|3=NCOA6 protein, human}}
• {{NURSA|C94}}

{{NLM content}}

{{Transcription coregulators}}

{{DEFAULTSORT:Ncoa6}}

Category:Gene expression

Category:Transcription coregulators

Category:Human proteins