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TIMP3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.{{cite journal | vauthors = Apte SS, Mattei MG, Olsen BR | title = Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22 | journal = Genomics | volume = 19 | issue = 1 | pages = 86–90 |date=Jun 1994 | pmid = 8188246 | doi = 10.1006/geno.1994.1016 }}{{cite journal | vauthors = Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B | title = A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2 | journal = Nat Med | volume = 9 | issue = 4 | pages = 407–15 |date=Apr 2003 | pmid = 12652295 | doi = 10.1038/nm846 | s2cid = 12563403 }}

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.{{cite web | title = Entrez Gene: TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7078}}

See also

References

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Further reading

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  • {{cite journal | vauthors=Li Z, Clarke MP, Barker MD, McKie N |title=TIMP3 mutation in Sorsby's fundus dystrophy: molecular insights. |journal=Expert Reviews in Molecular Medicine |volume=7 |issue= 24 |pages= 1–15 |year= 2007 |pmid= 16259644 |doi= 10.1017/S1462399405010045 |s2cid=20685857 }}
  • {{cite journal |vauthors=Docherty AJ, Lyons A, Smith BJ, etal |title=Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity |journal=Nature |volume=318 |issue= 6041 |pages= 66–9 |year= 1985 |pmid= 3903517 |doi=10.1038/318066a0 |bibcode=1985Natur.318...66D |s2cid=4325067 }}
  • {{cite journal | vauthors=Forsius HR, Eriksson AW, Suvanto EA, Alanko HI |title=Pseudoinflammatory fundus dystrophy with autosomal recessive inheritance. |journal=Am. J. Ophthalmol. |volume=94 |issue= 5 |pages= 634–49 |year= 1983 |pmid= 7148944 |doi= 10.1016/0002-9394(82)90009-5 }}
  • {{cite journal |vauthors=Wick M, Härönen R, Mumberg D, etal |title=Structure of the human TIMP-3 gene and its cell cycle-regulated promoter. | series=311 |journal=Biochem. J. |volume=( Pt 2) |issue= 2|pages= 549–54 |year= 1995 |pmid= 7487894 |doi= 10.1042/bj3110549| pmc=1136034 }}
  • {{cite journal |vauthors=Jacobson SG, Cideciyan AV, Regunath G, etal |title=Night blindness in Sorsby's fundus dystrophy reversed by vitamin A. |journal=Nat. Genet. |volume=11 |issue= 1 |pages= 27–32 |year= 1995 |pmid= 7550309 |doi= 10.1038/ng0995-27 |s2cid=7779127 }}
  • {{cite journal |vauthors=Higuchi T, Kanzaki H, Nakayama H, etal |title=Induction of tissue inhibitor of metalloproteinase 3 gene expression during in vitro decidualization of human endometrial stromal cells. |journal=Endocrinology |volume=136 |issue= 11 |pages= 4973–81 |year= 1995 |pmid= 7588231 |doi=10.1210/endo.136.11.7588231 }}
  • {{cite journal |vauthors=Wilde CG, Hawkins PR, Coleman RT, etal |title=Cloning and characterization of human tissue inhibitor of metalloproteinases-3. |journal=DNA Cell Biol. |volume=13 |issue= 7 |pages= 711–8 |year= 1995 |pmid= 7772252 |doi=10.1089/dna.1994.13.711 }}
  • {{cite journal | vauthors=Apte SS, Olsen BR, Murphy G |title=The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14313–8 |year= 1995 |pmid= 7782289 |doi=10.1074/jbc.270.24.14313 |doi-access=free }}
  • {{cite journal |vauthors=Kishnani NS, Staskus PW, Yang TT, etal |title=Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix. |journal=Matrix Biol. |volume=14 |issue= 6 |pages= 479–88 |year= 1995 |pmid= 7795886 |doi=10.1016/0945-053X(95)90005-5 }}
  • {{cite journal |vauthors=Weber BH, Vogt G, Pruett RC, etal |title=Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy. |journal=Nat. Genet. |volume=8 |issue= 4 |pages= 352–6 |year= 1995 |pmid= 7894485 |doi= 10.1038/ng1294-352 |s2cid=19386047 }}
  • {{cite journal |vauthors=Weber BH, Vogt G, Wolz W, etal |title=Sorsby's fundus dystrophy is genetically linked to chromosome 22q13-qter. |journal=Nat. Genet. |volume=7 |issue= 2 |pages= 158–61 |year= 1994 |pmid= 7920634 |doi= 10.1038/ng0694-158 |s2cid=22060034 }}
  • {{cite journal | vauthors=Jones SE, Jomary C, Neal MJ |title=Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa. |journal=FEBS Lett. |volume=352 |issue= 2 |pages= 171–4 |year= 1994 |pmid= 7925969 |doi=10.1016/0014-5793(94)00951-1 |s2cid=33038960 }}
  • {{cite journal |vauthors=Wick M, Bürger C, Brüsselbach S, etal |title=A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence. |journal=J. Biol. Chem. |volume=269 |issue= 29 |pages= 18953–60 |year= 1994 |doi=10.1016/S0021-9258(17)32259-7 |pmid= 8034652 |doi-access=free }}
  • {{cite journal | vauthors=Silbiger SM, Jacobsen VL, Cupples RL, Koski RA |title=Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family. |journal=Gene |volume=141 |issue= 2 |pages= 293–7 |year= 1994 |pmid= 8163205 |doi=10.1016/0378-1119(94)90588-6 }}
  • {{cite journal |vauthors=Uría JA, Ferrando AA, Velasco G, etal |title=Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family. |journal=Cancer Res. |volume=54 |issue= 8 |pages= 2091–4 |year= 1994 |pmid= 8174111 }}
  • {{cite journal |vauthors=Byrne JA, Tomasetto C, Rouyer N, etal |title=The tissue inhibitor of metalloproteinases-3 gene in breast carcinoma: identification of multiple polyadenylation sites and a stromal pattern of expression. |journal=Mol. Med. |volume=1 |issue= 4 |pages= 418–27 |year= 1996 |pmid= 8521299 |doi= 10.1007/BF03401579| pmc=2229996 }}
  • {{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
  • {{cite journal |vauthors=Felbor U, Stöhr H, Amann T, etal |title=A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features. |journal=Hum. Mol. Genet. |volume=4 |issue= 12 |pages= 2415–6 |year= 1996 |pmid= 8634721 |doi=10.1093/hmg/4.12.2415 }}
  • {{cite journal |vauthors=Carrero-Valenzuela RD, Klein ML, Weleber RG, etal |title=Sorsby fundus dystrophy. A family with the Ser181Cys mutation of the tissue inhibitor of metalloproteinases 3. |journal=Arch. Ophthalmol. |volume=114 |issue= 6 |pages= 737–8 |year= 1996 |pmid= 8639088 |doi= 10.1001/archopht.1996.01100130729016}}

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External links

  • The MEROPS online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I35.003 I35.003]

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