Login
Login

TMPRSS11D

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Technical|date=June 2024}}

{{Infobox_gene}}

Transmembrane protease, serine 11D is an enzyme that in humans is encoded by the TMPRSS11D gene.{{cite journal |vauthors=Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S | title = Cloning and characterization of the cDNA for human airway trypsin-like protease | journal = J Biol Chem | volume = 273 | issue = 19 | pages = 11895–901 |date=Jun 1998 | pmid = 9565616 | doi =10.1074/jbc.273.19.11895 | doi-access = free }}{{cite journal |vauthors=Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T | title = Purification, characterization, and localization of a novel trypsin-like protease found in the human airway | journal = Am J Respir Cell Mol Biol | volume = 16 | issue = 3 | pages = 300–8 |date=Apr 1997 | pmid = 9070615 | doi = 10.1165/ajrcmb.16.3.9070615}}{{cite web| title = Entrez Gene: TMPRSS11D transmembrane protease, serine 11D| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9407| access-date = 2017-09-15| archive-date = 2024-04-30| archive-url = https://web.archive.org/web/20240430165342/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9407| url-status = live}}

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | author=Takahashi M |title=Localization of human airway trypsin-like protease in the airway: an immunohistochemical study |journal=Histochem. Cell Biol. |volume=115 |issue= 3 |pages= 181–7 |year= 2001 |pmid= 11326745 |doi= 10.1007/s004180000243 |name-list-style=vanc| author2=Sano T | author3=Yamaoka K | display-authors=3 | last4=Kamimura | first4=T | last5=Umemoto | first5=N | last6=Nishitani | first6=H | last7=Yasuoka | first7=S |s2cid=25025224 }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Miki M |title=Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells |journal=J. Med. Invest. |volume=50 |issue= 1–2 |pages= 95–107 |year= 2003 |pmid= 12630574 |name-list-style=vanc| author2=Nakamura Y | author3=Takahashi A | display-authors=3 | last4=Nakaya | first4=Y | last5=Eguchi | first5=H | last6=Masegi | first6=T | last7=Yoneda | first7=K | last8=Yasuoka | first8=S | last9=Sone | first9=S }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal | author=Iwakiri K |title=Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris |journal=J. Invest. Dermatol. |volume=122 |issue= 4 |pages= 937–44 |year= 2004 |pmid= 15102084 |doi= 10.1111/j.0022-202X.2004.22415.x |name-list-style=vanc| author2=Ghazizadeh M | author3=Jin E | display-authors=3 | last4=Fujiwara | first4=Masakazu | last5=Takemura | first5=Tamiko | last6=Takezaki | first6=Shin-Ichiro | last7=Kawana | first7=Seiji | last8=Yasuoka | first8=Susumu | last9=Kawanami | first9=Oichi | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Matsushima R |title=Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=290 |issue= 2 |pages= L385–95 |year= 2006 |pmid= 16199437 |doi= 10.1152/ajplung.00098.2005 |name-list-style=vanc| author2=Takahashi A | author3=Nakaya Y | display-authors=3 | last4=Maezawa | first4=H | last5=Miki | first5=M | last6=Nakamura | first6=Y | last7=Ohgushi | first7=F | last8=Yasuoka | first8=S }}
  • {{cite journal | author=Chokki M |title=Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells |journal=FEBS J. |volume=272 |issue= 24 |pages= 6387–99 |year= 2006 |pmid= 16336275 |doi= 10.1111/j.1742-4658.2005.05035.x |name-list-style=vanc| author2=Eguchi H | author3=Hamamura I | display-authors=3 | last4=Mitsuhashi | first4=Hiroaki | last5=Kamimura | first5=Takashi |s2cid=34294232 |doi-access=free }}
  • {{cite journal | author=Böttcher E |title=Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium |journal=J. Virol. |volume=80 |issue= 19 |pages= 9896–8 |year= 2006 |pmid= 16973594 |doi= 10.1128/JVI.01118-06 | pmc=1617224 |name-list-style=vanc| author2=Matrosovich T | author3=Beyerle M | display-authors=3 | last4=Klenk | first4=H.-D. | last5=Garten | first5=W. | last6=Matrosovich | first6=M. }}

{{refend}}

External links

  • {{PDBe-KB2|Q8VHK8|Mouse Transmembrane protease serine 11D}}

{{gene-4-stub}}