TNFRSF19
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.{{cite web | title = Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55504}}
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TNF receptor associated factor (TRAF) family members, and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
See also
- Mitogen-activated protein kinase for JNK signaling pathway description
References
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Further reading
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- {{cite journal |vauthors=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, etal |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
- {{cite journal |vauthors=Kojima T, Morikawa Y, Copeland NG, etal |title=TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20742–7 |year= 2000 |pmid= 10764796 |doi= 10.1074/jbc.M002691200 |doi-access= free }}
- {{cite journal |vauthors=Eby MT, Jasmin A, Kumar A, etal |title=TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15336–42 |year= 2000 |pmid= 10809768 |doi=10.1074/jbc.275.20.15336 |doi-access=free }}
- {{cite journal |vauthors=Naito A, Yoshida H, Nishioka E, etal |title=TRAF6-deficient mice display hypohidrotic ectodermal dysplasia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 13 |pages= 8766–71 |year= 2002 |pmid= 12060722 |doi= 10.1073/pnas.132636999 | pmc=124373 |doi-access=free |bibcode=2002PNAS...99.8766N }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
- {{cite journal | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Park JB, Yiu G, Kaneko S, etal |title=A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors |journal=Neuron |volume=45 |issue= 3 |pages= 345–51 |year= 2005 |pmid= 15694321 |doi= 10.1016/j.neuron.2004.12.040 |doi-access= free }}
- {{cite journal |vauthors=Shao Z, Browning JL, Lee X, etal |title=TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration |journal=Neuron |volume=45 |issue= 3 |pages= 353–9 |year= 2005 |pmid= 15694322 |doi= 10.1016/j.neuron.2004.12.050 |doi-access= free }}
- {{cite journal | vauthors=Spanjaard RA, Whren KM, Graves C, Bhawan J |title=Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target |journal=Int. J. Cancer |volume=120 |issue= 6 |pages= 1304–10 |year= 2007 |pmid= 17187358 |doi= 10.1002/ijc.22367 |doi-access= free }}
- {{cite journal |vauthors=Satoh J, Tabunoki H, Yamamura T, etal |title=TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions |journal=Neuropathol. Appl. Neurobiol. |volume=33 |issue= 1 |pages= 99–107 |year= 2007 |pmid= 17239012 |doi= 10.1111/j.1365-2990.2006.00787.x |s2cid=36762956 }}
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{{Tumor necrosis factor receptor superfamily}}
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