TRPC1

TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types.

{{cite journal | vauthors = Xu SZ, Beech DJ | title = TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells | journal = Circulation Research | volume = 88 | issue = 1 | pages = 84–87 | date = Jan 2001 | pmid = 11139478 | doi = 10.1161/01.res.88.1.84 | doi-access = free }}

It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the phospholipase C system. In HEK293 cells the unitary current-voltage relationship of endogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV.{{cite journal | vauthors = Skopin A, Shalygin A, Vigont V, Zimina O, Glushankova L, Mozhayeva GN, Kaznacheyeva E | title = TRPC1 protein forms only one type of native store-operated channels in HEK293 cells | journal = Biochimie | volume = 95 | issue = 2 | pages = 347–353 | date = Feb 2013 | pmid = 23079337 | doi = 10.1016/j.biochi.2012.10.004 }}

The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5.

{{cite journal | vauthors = Fowler MA, Sidiropoulou K, Ozkan ED, Phillips CW, Cooper DC | title = Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain | journal = PLOS ONE | volume = 2 | issue = 6 | pages = e573 | year = 2007 | pmid = 17593972 | pmc = 1892805 | doi = 10.1371/journal.pone.0000573 | bibcode = 2007PLoSO...2..573F | doi-access = free }}{{cite journal | vauthors = Cooper D, Fowler M, Varnell A, Dietrich A, Birnbaumer L, Cooper D | title = Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine | journal = Nature Precedings | year = 2012 | doi = 10.1038/npre.2012.7153 | doi-broken-date = 1 November 2024 | doi-access = free }} The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.

TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the TRP channel in Drosophila. Together with TRPC3 they became the founding members of the TRPC ion channel family.

TRPC1 has been shown to interact with:

• HOMER3,{{cite journal | vauthors = Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF | title = Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors | journal = Cell | volume = 114 | issue = 6 | pages = 777–789 | date = Sep 2003 | pmid = 14505576 | doi = 10.1016/s0092-8674(03)00716-5 | s2cid = 10552676 | doi-access = free }}
• Polycystic kidney disease 2,{{cite journal | vauthors = Tsiokas L, Arnould T, Zhu C, Kim E, Walz G, Sukhatme VP | title = Specific association of the gene product of PKD2 with the TRPC1 channel | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 7 | pages = 3934–3939 | date = Mar 1999 | pmid = 10097141 | pmc = 22398 | doi = 10.1073/pnas.96.7.3934 | jstor = 47742 | bibcode = 1999PNAS...96.3934T | doi-access = free }}
• RHOA{{cite journal | vauthors = Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB | title = RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability | journal = The Journal of Biological Chemistry | volume = 278 | issue = 35 | pages = 33492–33500 | date = Aug 2003 | pmid = 12766172 | doi = 10.1074/jbc.M302401200 | doi-access = free }}
• TRPC3,{{cite journal | vauthors = Xu XZ, Li HS, Guggino WB, Montell C | title = Coassembly of TRP and TRPL produces a distinct store-operated conductance | journal = Cell | volume = 89 | issue = 7 | pages = 1155–1164 | date = Jun 1997 | pmid = 9215637 | doi = 10.1016/s0092-8674(00)80302-5 | s2cid = 15275438 | doi-access = free }}
• TRPC4, and
• TRPC5.{{cite journal | vauthors = Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE | title = Formation of novel TRPC channels by complex subunit interactions in embryonic brain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 40 | pages = 39014–39019 | date = Oct 2003 | pmid = 12857742 | doi = 10.1074/jbc.M306705200 | doi-access = free }}{{cite journal | vauthors = Hofmann T, Schaefer M, Schultz G, Gudermann T | title = Subunit composition of mammalian transient receptor potential channels in living cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 11 | pages = 7461–7466 | date = May 2002 | pmid = 12032305 | pmc = 124253 | doi = 10.1073/pnas.102596199 | bibcode = 2002PNAS...99.7461H | doi-access = free }}

• TRPC

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• {{cite book | vauthors = Rychkov G, Barritt GJ | chapter = TRPC1 Ca2+-Permeable Channels in Animal Cells | title = TRPC1 Ca(2+)-permeable channels in animal cells | volume = 179 | issue = 179 | pages = 23–52 | year = 2007 | pmid = 17217049 | doi = 10.1007/978-3-540-34891-7_2 | isbn = 978-3-540-34889-4 | series = Handbook of Experimental Pharmacology }}
• {{cite journal | vauthors = Ambudkar IS | title = TRPC1: a core component of store-operated calcium channels | journal = Biochemical Society Transactions | volume = 35 | issue = Pt 1 | pages = 96–100 | date = Feb 2007 | pmid = 17233611 | doi = 10.1042/BST0350096 }}

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• {{MeshName|TRPC1+protein,+human}}
• {{cite web | title = TRIP Database | url = http://www.trpchannel.org | work = a manually curated database of protein-protein interactions for mammalian TRP channels }}

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{{Ion channels|g4}}

{{Transient receptor potential channel modulators}}

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Category:Ion channels

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