TRPC5

TrpC5 is one of the seven mammalian TRPC (transient receptor potential canonical) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na⁺–H⁺ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).{{cite web | title = Entrez Gene: transient receptor potential cation channel| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7224}}

TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity{{cite journal | vauthors = Xu SZ, Zeng B, Daskoulidou N, Chen GL, Atkin SL, Lukhele B | title = Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure | journal = Toxicological Sciences | volume = 125 | issue = 1 | pages = 56–68 | date = January 2012 | pmid = 21984481 | doi = 10.1093/toxsci/kfr268 | doi-access = free }} and neurological behavior.{{cite journal | vauthors = Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE | title = Essential role for TRPC5 in amygdala function and fear-related behavior | journal = Cell | volume = 137 | issue = 4 | pages = 761–772 | date = May 2009 | pmid = 19450521 | pmc = 2719954 | doi = 10.1016/j.cell.2009.03.039 }} It was established in 2021 that TRPC5 is a component of the dental cold sensing system.{{cite journal | vauthors = Bernal L, Sotelo-Hitschfeld P, König C, Sinica V, Wyatt A, Winter Z, Hein A, Touska F, Reinhardt S, Tragl A, Kusuda R, Wartenberg P, Sclaroff A, Pfeifer JD, Ectors F, Dahl A, Freichel M, Vlachova V, Brauchi S, Roza C, Boehm U, Clapham DE, Lennerz JK, Zimmermann K | title = Odontoblast TRPC5 channels signal cold pain in teeth | journal = Science Advances | volume = 7 | issue = 13 | pages = eabf5567 | date = March 2021 | pmid = 33771873 | pmc = 7997515 | doi = 10.1126/sciadv.abf5567 | bibcode = 2021SciA....7.5567B }}

Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin.{{cite journal | vauthors = Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ | title = TRPC channel activation by extracellular thioredoxin | journal = Nature | volume = 451 | issue = 7174 | pages = 69–72 | date = January 2008 | pmid = 18172497 | pmc = 2645077 | doi = 10.1038/nature06414 | bibcode = 2008Natur.451...69X }} This channel has also been found to be involved in the action of anaesthetics such as chloroform, halothane and propofol.{{cite journal | vauthors = Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, Bateson AN, Beech DJ | title = Modulation of TRPC5 cation channels by halothane, chloroform and propofol | journal = British Journal of Pharmacology | volume = 153 | issue = 7 | pages = 1505–1512 | date = April 2008 | pmid = 18204473 | pmc = 2437913 | doi = 10.1038/sj.bjp.0707689 }}

TRPC5 has been shown to interact with STMN3,{{cite journal | vauthors = Greka A, Navarro B, Oancea E, Duggan A, Clapham DE | title = TRPC5 is a regulator of hippocampal neurite length and growth cone morphology | journal = Nature Neuroscience | volume = 6 | issue = 8 | pages = 837–845 | date = August 2003 | pmid = 12858178 | doi = 10.1038/nn1092 | s2cid = 7523946 }} TRPC1,{{cite journal | vauthors = Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE | title = Formation of novel TRPC channels by complex subunit interactions in embryonic brain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 40 | pages = 39014–39019 | date = October 2003 | pmid = 12857742 | doi = 10.1074/jbc.M306705200 | doi-access = free }}{{cite journal | vauthors = Hofmann T, Schaefer M, Schultz G, Gudermann T | title = Subunit composition of mammalian transient receptor potential channels in living cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 11 | pages = 7461–7466 | date = May 2002 | pmid = 12032305 | pmc = 124253 | doi = 10.1073/pnas.102596199 | doi-access = free | bibcode = 2002PNAS...99.7461H }} and TRPC4.

• TRPC

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• {{Cite book | vauthors = Beech DJ | title = Transient Receptor Potential (TRP) Channels | chapter = Canonical transient receptor potential 5 | volume = 179 | issue = 179 | pages = 109–23 | year = 2007 | pmid = 17217053 | doi = 10.1007/978-3-540-34891-7_6 | isbn = 978-3-540-34889-4 | series = Handbook of Experimental Pharmacology }}
• {{cite journal | vauthors = Beech DJ | title = Bipolar phospholipid sensing by TRPC5 calcium channel | journal = Biochemical Society Transactions | volume = 35 | issue = Pt 1 | pages = 101–104 | date = February 2007 | pmid = 17233612 | doi = 10.1042/BST0350101 }}

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• {{MeshName|TRPC5+protein,+human}}

{{NLM content}}

{{Ion channels|g4}}

{{Transient receptor potential channel modulators}}

{{DEFAULTSORT:Trpc5}}

Category:Ion channels

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