TUBA1B
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.{{cite journal | author = Banerjee A | title = Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells | journal = Biochem Biophys Res Commun | volume = 293 | issue = 1 | pages = 598–601 |date=Jun 2002 | pmid = 12054644 | doi = 10.1016/S0006-291X(02)00269-3 }}{{cite journal |vauthors=Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW | title = Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions | journal = Mol Cell Biol | volume = 3 | issue = 10 | pages = 1738–45 |date=Jan 1984 | pmid = 6646120 | pmc = 370035 | doi = 10.1128/mcb.3.10.1738}}{{cite web | title = Entrez Gene: TUBA1B tubulin, alpha 1b| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10376}}
Interactions
TUBA1B has been shown to interact with PIK3R1.{{cite journal |doi=10.1074/jbc.270.43.25985 |last=Kapeller |first=R |author2=Toker A |author3=Cantley L C |author4=Carpenter C L |date=Oct 1995 |title=Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin |journal=J. Biol. Chem. |volume=270 |issue=43 |pages=25985–91 |location = UNITED STATES| issn = 0021-9258| pmid = 7592789 |doi-access=free }}
Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.{{Cite web|url=https://www.genetex.com/Product/Detail/alpha-Tubulin-antibody-GT114/GTX628802|title = Anti-alpha Tubulin antibody [GT114] (GTX628802) | GeneTex}}
References
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Further reading
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- {{cite journal | author=Venter JC |title=Identification of new human receptor and transporter genes by high throughput cDNA (EST) sequencing. | series=45 |journal=J. Pharm. Pharmacol. |volume=Suppl 1 |pages= 355–60 |year= 1993 |pmid= 8098743 }}
- {{cite journal |vauthors=Lopez-Fanarraga M, Avila J, Guasch A, etal |title=Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics. |journal=J. Struct. Biol. |volume=135 |issue= 2 |pages= 219–29 |year= 2002 |pmid= 11580271 |doi= 10.1006/jsbi.2001.4386 }}
- {{cite journal |vauthors=Kapeller R, Toker A, Cantley LC, Carpenter CL |title=Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25985–91 |year= 1995 |pmid= 7592789 |doi=10.1074/jbc.270.43.25985 |doi-access=free }}
- {{cite journal |vauthors=Alexandrova N, Niklinski J, Bliskovsky V, etal |title=The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5188–95 |year= 1995 |pmid= 7651436 |doi= 10.1128/mcb.15.9.5188| pmc=230766 }}
- {{cite journal |vauthors=Szasz J, Yaffe MB, Sternlicht H |title=Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region. |journal=Biophys. J. |volume=64 |issue= 3 |pages= 792–802 |year= 1993 |pmid= 8097117 |doi=10.1016/S0006-3495(93)81440-1 | pmc=1262393 |bibcode=1993BpJ....64..792S }}
- {{cite journal |vauthors=Baumann MH, Wisniewski T, Levy E, etal |title=C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. |journal=Biochem. Biophys. Res. Commun. |volume=219 |issue= 1 |pages= 238–42 |year= 1996 |pmid= 8619814 |doi= 10.1006/bbrc.1996.0211 |doi-access= free }}
- {{cite journal |vauthors=Gress TM, Müller-Pillasch F, Geng M, etal |title=A pancreatic cancer-specific expression profile. |journal=Oncogene |volume=13 |issue= 8 |pages= 1819–30 |year= 1996 |pmid= 8895530 }}
- {{cite journal |vauthors=Crépieux P, Kwon H, Leclerc N, etal |title=I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7375–85 |year= 1997 |pmid= 9372968 |doi= 10.1128/mcb.17.12.7375| pmc=232593 }}
- {{cite journal |vauthors=Herreros L, Rodríguez-Fernandez JL, Brown MC, etal |title=Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26436–40 |year= 2000 |pmid= 10840040 |doi= 10.1074/jbc.M003970200 |doi-access= free |hdl= 10261/135387 |hdl-access= free }}
- {{cite journal |vauthors=Watts NR, Sackett DL, Ward RD, etal |title=HIV-1 rev depolymerizes microtubules to form stable bilayered rings. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 349–60 |year= 2000 |pmid= 10908577 |doi=10.1083/jcb.150.2.349 | pmc=2180222 }}
- {{cite journal |vauthors=Takeoka A, Shimizu M, Horio T |title=Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction. | series=113 |journal=J. Cell Sci. |volume=Pt 24 |pages= 4557–62 |year= 2001 |issue=24 |doi=10.1242/jcs.113.24.4557 |pmid= 11082048 }}
- {{cite journal |vauthors=Germani A, Bruzzoni-Giovanelli H, Fellous A, etal |title=SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. |journal=Oncogene |volume=19 |issue= 52 |pages= 5997–6006 |year= 2001 |pmid= 11146551 |doi= 10.1038/sj.onc.1204002 |doi-access= free }}
- {{cite journal |vauthors=Yokota S, Yanagi H, Yura T, Kubota H |title=Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. |journal=Eur. J. Biochem. |volume=268 |issue= 17 |pages= 4664–73 |year= 2001 |pmid= 11532003 |doi=10.1046/j.1432-1327.2001.02393.x }}
- {{cite journal |vauthors=Rommelaere H, De Neve M, Neirynck K, etal |title=Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41023–8 |year= 2001 |pmid= 11535601 |doi= 10.1074/jbc.M106591200 |doi-access= free }}
- {{cite journal |vauthors=Klein C, Kramer EM, Cardine AM, etal |title=Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. |journal=J. Neurosci. |volume=22 |issue= 3 |pages= 698–707 |year= 2002 |pmid= 11826099 |pmc=6758498 |doi= 10.1523/JNEUROSCI.22-03-00698.2002}}
- {{cite journal |vauthors=Saugstad JA, Yang S, Pohl J, etal |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980–8 |year= 2002 |pmid= 11953448 | pmc=2925652 |doi=10.1046/j.0022-3042.2002.00778.x }}
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External links
- {{UCSC genome browser|TUBA1B}}
- {{UCSC gene details|TUBA1B}}
{{PDB Gallery|geneid=10376}}
{{gene-12-stub}}{{Cytoskeletal proteins}}