TYRO3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.{{cite journal | vauthors = Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C | title = Regional localization of human chromosome 15 loci | journal = Genomics | volume = 23 | issue = 3 | pages = 619–27 | date = March 1995 | pmid = 7851890 | doi = 10.1006/geno.1994.1550 }}{{cite web | title = Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7301}}
Interactions
TYRO3 has been shown to interact with:
- GAS6,{{cite journal | vauthors = Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ | title = Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl | journal = J. Biol. Chem. | volume = 271 | issue = 16 | pages = 9785–9 | date = April 1996 | pmid = 8621659 | doi = 10.1074/jbc.271.16.9785| doi-access = free }}{{cite journal | vauthors = Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K | title = Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases | journal = J. Biol. Chem. | volume = 271 | issue = 47 | pages = 30022–7 | date = November 1996 | pmid = 8939948 | doi = 10.1074/jbc.271.47.30022| doi-access = free }} and
- PIK3R1{{cite journal | vauthors = Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W | title = Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway | journal = Blood | volume = 95 | issue = 2 | pages = 633–8 | date = January 2000 | doi = 10.1182/blood.V95.2.633 | pmid = 10627473 }}
References
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Further reading
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- {{cite journal | vauthors = Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ | title = rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain | journal = J. Biol. Chem. | volume = 269 | issue = 14 | pages = 10720–8 | year = 1994 | doi = 10.1016/S0021-9258(17)34118-2 | pmid = 7511603 | doi-access = free }}
- {{cite journal | vauthors = Toshima J, Ohashi K, Iwashita S, Mizuno K | title = Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase | journal = Biochem. Biophys. Res. Commun. | volume = 209 | issue = 2 | pages = 656–63 | year = 1995 | pmid = 7537495 | doi = 10.1006/bbrc.1995.1549 }}
- {{cite journal | vauthors = Crosier KE, Hall LR, Lewis PM, Morris CM, Wood CR, Morris JC, Crosier PS | title = Isolation and characterization of the human DTK receptor tyrosine kinase | journal = Growth Factors | volume = 11 | issue = 2 | pages = 137–44 | year = 1995 | pmid = 7857658 | doi = 10.3109/08977199409001055 }}
- {{cite journal | vauthors = Ohashi K, Mizuno K, Kuma K, Miyata T, Nakamura T | title = Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain | journal = Oncogene | volume = 9 | issue = 3 | pages = 699–705 | year = 1994 | pmid = 8108112 }}
- {{cite journal | vauthors = Dai W, Pan H, Hassanain H, Gupta SL, Murphy MJ | title = Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis | journal = Oncogene | volume = 9 | issue = 3 | pages = 975–9 | year = 1994 | pmid = 8108143 }}
- {{cite journal | vauthors = Polvi A, Armstrong E, Lai C, Lemke G, Huebner K, Spritz RA, Guida LC, Nicholls RD, Alitalo K | title = The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25 | journal = Gene | volume = 134 | issue = 2 | pages = 289–93 | year = 1994 | pmid = 8262388 | doi = 10.1016/0378-1119(93)90109-G }}
- {{cite journal | vauthors = Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ | title = Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl | journal = J. Biol. Chem. | volume = 271 | issue = 16 | pages = 9785–9 | year = 1996 | pmid = 8621659 | doi = 10.1074/jbc.271.16.9785 | doi-access = free }}
- {{cite journal | vauthors = Crosier PS, Freeman SA, Orlic D, Bodine DM, Crosier KE | title = The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis | journal = Exp. Hematol. | volume = 24 | issue = 2 | pages = 318–23 | year = 1996 | pmid = 8641360 }}
- {{cite journal | vauthors = Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K | title = Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases | journal = J. Biol. Chem. | volume = 271 | issue = 47 | pages = 30022–7 | year = 1997 | pmid = 8939948 | doi = 10.1074/jbc.271.47.30022 | doi-access = free }}
- {{cite journal | vauthors = Kajii Y, Ninomiya D, Kato M, Mizuguchi M, Saji M, Katsumoto T, Ohno K, Takashima S, Onodera K | title = A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress | journal = Biol. Cell | volume = 88 | issue = 1–2 | pages = 45–54 | year = 1997 | pmid = 9175267 | doi = 10.1016/S0248-4900(97)86830-X | s2cid = 31494402 }}
- {{cite journal | vauthors = Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W | title = Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway | journal = Blood | volume = 95 | issue = 2 | pages = 633–8 | year = 2000 | doi = 10.1182/blood.V95.2.633 | pmid = 10627473 }}
- {{cite journal | vauthors = Yin JL, Hambly BD, Bao SS, Painter D, Bishop GA, Eris JM | title = Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts | journal = Transpl. Int. | volume = 16 | issue = 9 | pages = 681–8 | year = 2004 | pmid = 12768229 | doi = 10.1007/s00147-003-0593-3 | s2cid = 13419387 }}
- {{cite journal | vauthors = Heiring C, Dahlbäck B, Muller YA | title = Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family | journal = J. Biol. Chem. | volume = 279 | issue = 8 | pages = 6952–8 | year = 2004 | pmid = 14623883 | doi = 10.1074/jbc.M311750200 | doi-access = free }}
- {{cite journal | vauthors = Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA | title = Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses | journal = J. Thromb. Haemost. | volume = 3 | issue = 4 | pages = 733–41 | year = 2005 | pmid = 15733062 | doi = 10.1111/j.1538-7836.2005.01186.x | doi-access = free }}
- {{cite journal | vauthors = Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B | title = The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases | journal = Int. J. Biochem. Cell Biol. | volume = 37 | issue = 11 | pages = 2344–56 | year = 2005 | pmid = 15964779 | doi = 10.1016/j.biocel.2005.05.006 }}
- {{cite journal | vauthors = Shimojima M, Takada A, Ebihara H, Neumann G, Fujioka K, Irimura T, Jones S, Feldmann H, Kawaoka Y | title = Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses | journal = J. Virol. | volume = 80 | issue = 20 | pages = 10109–16 | year = 2006 | pmid = 17005688 | pmc = 1617303 | doi = 10.1128/JVI.01157-06 }}
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{{PDB Gallery|geneid=7301}}
{{Tyrosine kinases}}
{{gene-15-stub}}