Tixocortol pivalate
{{chembox
| Verifiedfields = changed
| verifiedrevid = 433985492
| ImageFile=Tixocortol pivalate.svg
| ImageSize=250px
| IUPACName=S-(11β,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl) 2,2-dimethylpropanethioate
| SystematicName=S-
| OtherNames=
|Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo=55560-96-8
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 6K28E35M3B
| PubChem=15052414
| SMILES=CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CSC(=O)C(C)(C)C)O)C)O
}}
|Section2={{Chembox Properties
| Formula=C26H38O5S
| MolarMass=462.64
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
}}
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}
}}
Tixocortol pivalate is a corticosteroid. It has anti-inflammatory properties similar to hydrocortisone.{{cite journal|url = http://www.nature.com/clpt/journal/v33/n3/abs/clpt198343a.html | title = Tixocortol pivalate, a corticosteroid with no systemic glucocorticoid effect after oral, intrarectal, and intranasal application | author = P Larochelle MD, PhD | author2 = P Du Souich MD, PhD | author3 = E Bolte MD | author4 = J Lelorier MD, PhD | author5 = R Goyer PhD | name-list-style = amp | journal = Clinical Pharmacology and Therapeutics | year = 1983 | issue = 3| pages = 343–350 | doi = 10.1038/clpt.1983.43|access-date = 2011-03-29 | volume=33 | pmid=6402333| s2cid = 29876079 | url-access = subscription }} It is marketed under the brand name Pivalone.{{cite web | url = https://www.drugs.com/international/tixocortol-pivalate.html | title = Tixocortol Pivalate | work = Drugs.com | access-date = 2011-03-29}}
It is sometimes used in patch testing in atopic dermatitis.{{cite journal |vauthors=Nedorost ST, Babineau D |title=Patch testing in atopic dermatitis |journal=Dermatitis |volume=21 |issue=5 |pages=251–4 |date=October 2010 |pmid=20920410 |doi= 10.2310/6620.2010.10036|s2cid=25026888 |url=http://www.bcdecker.com/pubMedLinkOut.aspx?pub=AJCDO&vol=21&iss=5&page=251|url-access=subscription }}
See also
References
{{Reflist|2}}
{{Glucocorticoids}}
{{Glucocorticoidics}}
Category:Corticosteroid esters
{{pharma-stub}}