Triclofos

{{Short description|Pharmaceutical drug}}

{{Drugbox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 470613712

| IUPAC_name = 2,2,2-trichloroethanol dihydrogen phosphate

| image = Triclofos-2D-skeletal.svg

| image_class = skin-invert-image

| image2 = Triclofos-3D-balls.png

| tradename =

| Drugs.com = {{drugs.com|international|triclofos}}

| pregnancy_AU =

| pregnancy_US =

| pregnancy_category =

| legal_AU =

| legal_BR = C1

| legal_BR_comment = {{Cite web |author=Anvisa |author-link=Brazilian Health Regulatory Agency |date=2023-03-31 |title=RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial |trans-title=Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control|url=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |url-status=live |archive-url=https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |archive-date=2023-08-03 |access-date=2023-08-16 |publisher=Diário Oficial da União |language=pt-BR |publication-date=2023-04-04}}

| legal_CA =

| legal_UK =

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| routes_of_administration =

| bioavailability =

| protein_bound =

| metabolism =

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| CAS_number_Ref = {{cascite|changed|??}}

| CAS_number = 306-52-5

| CAS_supplemental = 8060-81-9

| ATC_prefix = N05

| ATC_suffix = CM07

| PubChem = 5563

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank =

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 5362

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = J712EO9048

| KEGG = C07165

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 1201317

| C=2 | H=4 | Cl=3 | O=4 | P=1

| smiles = ClC(Cl)(Cl)COP(=O)(O)O

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C2H4Cl3O4P/c3-2(4,5)1-9-10(6,7)8/h1H2,(H2,6,7,8)

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = YYQRGCZGSFRBAM-UHFFFAOYSA-N

}}

Triclofos is a sedative drug used rarely for treating insomnia.{{cite book | vauthors = Erhorn S |title=xPharm: The Comprehensive Pharmacology Reference |date=2007 |publisher=Elsevier |isbn=978-0-08-055232-3 |pages=1–4 |chapter-url=https://www.sciencedirect.com/science/article/pii/B9780080552323627977 | doi = 10.1016/B978-008055232-3.62797-7 |access-date=29 February 2020 |language=en |chapter=Triclofos}}

Triclofos is a prodrug which is metabolised in the liver into the active drug trichloroethanol. The half-life of triclofos is fairly long and it may cause drowsiness the next day. Trichloroethanol may cause liver damage and triclofos should not be used for extended periods.

Triclofos is no longer available in the United States.{{cite web |title=Drugs@FDA: FDA-Approved Drugs |url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=016809 |archive-url=https://web.archive.org/web/20170501004006/https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=016809 |url-status=dead |archive-date=May 1, 2017 |website=www.accessdata.fda.gov |access-date=29 February 2020}}