U.S. Route 76 in South Carolina#Newberry business loop

{{Infobox road

|state=SC

|type=US

|route=76

|map={{maplink|frame=yes|plain=yes|frame-align=center|frame-width=290|frame-height=240|type=line|from=U.S. Route 76 in South Carolina.map}}

|map_custom=yes

|map_notes=Route of US 76 in South Carolina highlighted in red

|length_mi=297.9

|length_ref={{google maps |url = https://maps.google.com/maps?saddr=US-76+E&daddr=34.630535,-82.781938+to:34.5169311,-82.6590019+to:34.5099471,-82.4752829+to:34.4367444,-81.828178+to:34.2261695,-81.5465894+to:34.1369417,-81.2982717+to:34.1130279,-81.194216+to:34.0029486,-81.0279288+to:33.9861929,-80.9708815+to:33.9303731,-80.2931151+to:34.1970644,-79.7175014+to:US-76+W&hl=en&ll=33.564284,-80.952759&spn=3.945168,7.13562&sll=34.125448,-81.252651&sspn=0.122493,0.222988&geocode=Ff04EwIdetcI-w%3BFYdrEAIdDtkQ-ymxdlEQdGdYiDGjeX3tG4nncg%3BFcOvDgIdR7kS-ymnC8yIhW5YiDGhHPpPEjTg3Q%3BFXuUDgId7oYV-yl3VT81fRFYiDH95hDUftP7lA%3BFYh2DQIdrmYf-ymRKazb5sJXiDGjstkEb2PD2Q%3BFfk_CgIdo7Ij-yld0u1qZdVXiDFoC3gGNXG_yA%3BFW3jCAIdoXwn-ylbebhE9Jz4iDFZz1Gi5ODyow%3BFQOGCAIdGBMp-ylR4iZqMJ_4iDE5c0p0_NsPqA%3BFQTYBgIdqJwr-ynz28bW1Lr4iDGnaVceAfZ30g%3BFZCWBgIdf3ss-ymh5OOXELD4iDGMEjQvDtY6dA%3BFYW8BQIdBdM2-ymF8rb-62__iDGJHSemKlhEjQ%3BFUjOCQIdg5s_-ylbyWDjl11ViDELVnksV2LHIg%3BFV37CgId6exJ-w&mra=dpe&mrsp=7&sz=13&via=1,2,3,4,5,6,7,8,9,10,11&t=p&z=8 |title = Overview Map of US 76 in South Carolina |access-date = February 15, 2014}}

|established=1926

|direction_a=West

|terminus_a={{Jct|state=GA|US|76|SR|2}} at the Georgia state line near Clayton

|junction=

{{Jct|state=SC|I|85}} near Anderson
{{jct|state=SC|I|26|US|176}} in Irmo
{{jct|state=SC|I|20}} on the Seven Oaks–St. Andrews city line
{{jct|state=SC|I|26|I|126}} near West Columbia
{{jct|state=SC|US|1|US|378}} in Columbia
{{jct|state=SC|US|15|US|401|US|378|US|521}} in Sumter
{{jct|state=SC|I|95}} near Florence

|direction_b=East

|terminus_b={{jct|state=NC|US|76}} at the North Carolina state line near Fair Bluff, NC

|counties=Oconee, Pickens, Anderson, Greenville, Laurens, Newberry, Richland, Lexington, Sumter, Lee, Florence, Marion, Horry

|previous_type=SC

|previous_route=75

|next_type=I

|next_route=77

}}

U.S. Route 76 (US 76) is an east–west U.S. highway in the U.S. state of South Carolina. Being one of the longest and most important highways in the state, it connects the cities of Anderson, Columbia, Sumter and Florence.

Route description

{{Multiple issues|section=yes|

}}

US 76 enters South Carolina across the Chattooga River, then continues southeast toward Westminster. This segment is a moderately windy two-lane road.{{citation needed|date=May 2014}} In Westminster, it heads east toward Seneca and Clemson. From Clemson, the road heads southeast toward Anderson, intersecting Interstate 85 (I-85), then east toward the small towns of Belton and Honea Path. US 76 is a four-lane highway from Westminster to Anderson. In Anderson, the road widens to six lanes with a reversible turn lane. After a concurrency with US 178, the road narrows to five lanes, and, as it goes south towards downtown Anderson, it narrows againk to four. However, the sections around Seneca, Clemson, and Anderson are well developed with many traffic lights. It travels concurrent with US 123 from Westminster to Clemson, SC 28 from Seneca to Anderson, and US 178 from Anderson to Honea Path.

From Honea Path, the highway heads east to Laurens. This section is a rural two-lane road that is not frequently traveled.{{citation needed|date=May 2014}} From Laurens, US 76 roughly parallels I-385 and I-26 as it heads to Columbia. US 76 provides local access to the communities of Laurens, Clinton, Newberry, Prosperity, Chapin, and the other smaller towns in the area. In Irmo, US 76 travels concurrent with US 176, then continues on to I-26, with which it travels concurrent. After the interchange with I-20, US 76 splits off from I-26 and continues into downtown Columbia concurrent with I-126.

In Columbia, US 76 follows Elmwood Avenue, Bull Street, Gervais Street, Millwood Avenue, and Devine Street, before heading east toward Sumter. The segment from Columbia to Sumter is a four-lane highway and US 76 is concurrent with US 378 from the intersection of Bull and Gervais near the University of South Carolina in Columbia all the way to Sumter. From Sumter, US 76 heads northeast to Florence. US 76 is the major road through Florence. It then continues east out of Florence to the small towns of Marion and Mullins, then into North Carolina. The highway is concurrent with US 301 from Florence to across the Pee Dee River.

History

{{Multiple issues|section=yes|

}}

Formerly, US 76 followed a longer route from Westminster to Pendleton. From Westminster, the old route followed S-37-13 through the Richland community, then its current alignment to SC 59 into downtown Seneca, then SC 130 out of Seneca to S-37-1, then its current alignment to SC 93 toward Clemson University, then SC 28 Business through Pendleton.

Major intersections

{{SCint|exit

|county=Oconee

|cspan=8

|location=none

|mile=0.0

|road={{jct|state=GA|US|76|SR|2|dir1=west|dir2=west|city1=Clayton}}

|notes=Continuation from Georgia over the Chattooga River

}}

{{SCint|exit

|location=Westminster

|lspan=3

|type=concur

|mile=17.5

|road={{jct|state=SC|US|123|dir1=south|name1=Toccoa Highway|location1=Toccoa}}

|notes=South end of US 123 overlap}}

{{SCint|exit

|mile=17.7

|road={{jct|state=SC|SC|183|dir1=north|name1=Westminster Highway|city1=Walhalla}}}}

{{SCint|exit

|mile=18.8

|road={{jct|state=SC|SC|24|dir1=east|name1=Oak Highway|city1=Townville}}}}

{{SCint|exit

|location=none

|mile=21.7

|road={{jct|state=SC|SC|11|name1=Cherokee Foothills Scenic Highway|city1=Walhalla}}}}

{{SCint|exit

|location=Seneca

|lspan=2

|type=concur

|mile=25.8

|road={{jct|state=SC|SC|28|SC|59|dir1=west|dir2=south|name1=Blue Ridge Boulevard|name2=North 1st Street|city1=Walhalla|city2=Seneca}}

|notes=West end of SC 28 overlap}}

{{SCint|exit

|mile=28.3

|road={{jct|state=SC|SC|130|name1=North 1st Street|city1=Salem|city2=Seneca}}}}

{{SCint|exit

|location=none

|mile=32.7

|road={{jct|state=SC|SC|93|dir1=east|city1=Clemson}}

|notes=To Clemson University}}

{{SCint|exit

|county=Pickens

|cspan=4

|location=Clemson

|lspan=4

|mile=34.5

|road={{jct|state=SC|SC|133|dir1=north|name1=College Avenue|city1=Six Mile|city2=Clemson}}

|notes=To Clemson University and John C. Calhoun Home}}

{{SCint|exit

|type=concur

|mile=34.9

|road={{jct|state=SC|US|123|dir1=north|name1=Tiger Boulevard|city1=Easley|city2=Greenville}}

|notes=North end of US 123 overlap}}

{{SCint|exit

|mile=35.6

|road={{jct|state=SC|SC|93|name1=Old Greenville Highway|city1=Central|city2=Norris}}

|notes=To Clemson University}}

{{SCint|exit

|mile=36.1

|road={{jct|state=SC|SC-Bus|28|dab1=Pendleton|dir1=east|name1=Pendleton Road|city1=Pendleton}}}}

{{SCint|exit

|county=Anderson

|cspan=20

|location=Pendleton

|mile=36.1

|road={{jct|state=SC|SC-Bus|28|dab1=Pendleton|dir1=west|name1=Mechanic Street|city1=Pendleton}}}}

{{SCint|exit

|location=none

|mile=40.1

|road={{jct|state=SC|SC|187|dir1=south}}}}

{{SCint|exit

|location=none

|mile=46.0

|road={{jct|state=SC|I|85|location1=Atlanta|city2=Greenville}}}}

{{SCint|exit

|location=none

|type=concur

|mile=47.7

|road={{jct|state=SC|SC|28|dir1=east|city1=Starr|city2=Abbeville}}

|notes=East end of SC 28 and west end of SC 28 Business overlap}}

{{SCint|exit

|location=none

|type=concur

|mile=47.7

|road={{jct|state=SC|SC|28|dir1=east|name1=Pearman Dairy Road|city1=Starr|city2=Abbeville}}

|notes=East end of SC 28 and west end of SC 28 Business overlap}}

{{SCint|exit

|location=Anderson

|lspan=8

|type=concur

|mile=48.5

|road={{jct|state=SC|US|178|dir1=west|name1=Liberty Highway|city1=Liberty}}

|notes=West end of US 178 overlap}}

{{SCint|exit

|type=concur

|mile=49.8

|road={{jct|state=SC|SC-Bus|28|dab1=Anderson|dir1=east|name1=Main Street}}

|notes=East end of SC 28 Business overlap}}

{{SCint|exit

|type=concur

|mile=52.1

|road={{jct|state=SC|US-Bus|29|SC|81|dab1=Anderson|dir1=north|dir2=north|name2=Greenville Street}}

|notes=North end of US 29 Business and SC 81 overlap}}

{{SCint|exit

|mile=52.4

|road={{jct|state=SC|SC|24|name1=Whitner Street}}}}

{{SCint|exit

|type=concur

|mile=52.7

|road={{jct|state=SC|SC|81|dir1=south|name1=Murray Street|city1=Starr}}

|notes=South end of US 29 Business and SC 81 overlap}}

{{SCint|exit

|mile=52.7

|road={{jct|state=SC|SC-Bus|28|dab1=Anderson|name1=Main Street|city1=Abbeville|location2=Augusta}}}}

{{SCint|exit

|type=concur

|mile=54.0

|road={{jct|state=SC|US|29|dir1=south|name1=Shockley Ferry Road}}

|notes=South end of US 29 overlap}}

{{SCint|exit

|type=concur

|mile=54.6

|road={{jct|state=SC|US|29|dir1=north}}

|notes=North end of US 29 overlap}}

{{SCint|exit

|location=none

|mile=58.2

|road={{jct|state=SC|SC|252|dir1=east|city1=Honea Path}}}}

{{SCint|exit

|location=none

|mile=61.1

|road={{jct|state=SC|SC|413|city1=Iva}}}}

{{SCint|exit

|location=Belton

|lspan=2

|type=concur

|mile=63.6

|road={{jct|state=SC|SC|20|dir1=east|name1=Brown Avenue|city1=Due West}}

|notes=East end of SC 20 overlap}}

{{SCint|exit

|type=concur

|mile=63.7

|road={{jct|state=SC|SC|20|dir1=west|name1=Main Street|city1=Williamston}}

|notes=West end of SC 20 overlap}}

{{SCint|exit

|location=Honea Path

|lspan=3

|type=concur

|mile=71.7

|road={{jct|state=SC|SC|252|dir1=west|name1=Greer Street|city1=Anderson}}

|notes=West end of SC 252 overlap}}

{{SCint|exit

|type=concur

|mile=71.8

|road={{jct|state=SC|US|178|dir1=east|name1=Church Street|city1=Due West|city2=Greenwood}}

|notes=East end of US 178 overlap}}

{{SCint|exit

|type=concur

|mile=72.3

|road={{jct|state=SC|SC|252|dir1=east|name1=Greer Street|city1=Ware Shoals}}

|notes=East end of SC 252 overlap}}

{{SCint|exit

|county=Greenville

|cspan=2

|location=none

|type=concur

|mile=78.9

|road={{jct|state=SC|US|25|dir1=north|name1=Augusta Road|city1=Greenville}}

|notes=North end of US 25 overlap}}

{{SCint|exit

|location=Princeton

|type=concur

|mile=80.1

|road={{jct|state=SC|US|25|dir1=south|name1=Augusta Road|city1=Ware Shoals|city2=Greenwood}}

|notes=South end of US 25 overlap}}

{{SCint|exit

|county=Laurens

|cspan=10

|location=Hickory Tavern

|mile=86.2

|road={{jct|state=SC|SC|101|dir1=north|road|Neely Ferry Road|city1=Gray Court|city2=Waterloo}}}}

{{SCint|exit

|location=Laurens

|lspan=6

|mile=94.0

|road={{jct|state=SC|SC|252|dir1=west|city1=Ware Shoals}}}}

{{SCint|exit

|mile=95.4

|road={{jct|state=SC|US-Bus|76|dab1=Laurens|dir1=east|name1=Main Street}}}}

{{SCint|exit

|type=concur

|mile=96.7

|road={{jct|state=SC|SC|14|dir1=north|name1=Church Street|city1=Greenville}}

|notes=North end of SC 14 overlap}}

{{SCint|exit

|type=concur

|mile=96.9

|road={{jct|state=SC|SC|14|dir1=south|name1=Church Street|city1=Laurens|city2=Greenwood}}

|notes=South end of SC 14 overlap}}

{{SCint|exit

|mile=97.7

|road={{jct|state=SC|US|221|name1=Harper Street|city1=Woodruff|city2=Spartanburg|city3=Greenwood}}}}

{{SCint|exit

|mile=99.5

|road={{jct|state=SC|US-Bus|76|SC|127|dir1=west|dir2=south|dab1=Laurens|name1=Main Street|city1=Laurens|city2=Greenwood}}}}

{{SCint|exit

|location=Clinton

|lspan=2

|mile=105.9

|road={{jct|state=SC|SC-Bus|56|SC-Bus|72|dab1=Clinton|dab2=Clinton|name2=Broad Street|city1=Whitmire|city2=Spartanburg|city3=Greenwood|city4=Saluda}}}}

{{SCint|exit

|mile=107.7

|road={{jct|state=SC|SC|56|SC|72|name2=Springdale Drive|city1=Whitmire|city2=Spartanburg|city3=Greenwood|city4=Saluda}}}}

{{SCint|exit

|location=Joanna

|mile=111.8

|road={{jct|state=SC|SC|66|name1=Whitmire Highway|city1=Whitmire|city2=Chappells}}}}

{{SCint|exit

|county=Newberry

|cspan=8

|location=Kinards

|mile=114.9

|road={{jct|state=SC|SC|560|dir1=west|city1=Cross Hill}}}}

{{SCint|exit

|location=Newberry

|lspan=4

|mile=125.7

|road={{jct|state=SC|SC|121|name1=College Street|city1=Whitmire|city2=Newberry}}}}

{{SCint|exit

|type=concur

|mile=127.7

|road={{jct|state=SC|SC|34|dir1=east|name1=Winnsboro Road|city1=Winnsboro}}

|notes=East end of SC 34 overlap}}

{{SCint|exit

|mile=127.9

|road={{jct|state=SC|SC|219|dir1=east|name1=Main Street|city1=Pomaria}}}}

{{SCint|exit

|type=concur

|mile=128.6

|road={{jct|state=SC|SC|34|dir1=west|name1=Dixie Drive|city1=Greenwood}}

|notes=West end of SC 34 overlap}}

{{SCint|exit

|location=Prosperity

|mile=133.5

|road={{jct|state=SC|SC|391|dir1=south|name1=Main Street|city1=Batesburg-Leesville}}}}

{{SCint|exit

|location=none

|mile=137.2

|road={{jct|state=SC|SC|773|dir1=north|city1=Pomaria}}}}

{{SCint|exit

|location=Little Mountain

|mile=141.6

|road={{jct|state=SC|SC|202|dir1=east|city1=Pomaria}}}}

{{SCint|exit

|county=Richland

|cspan=5

|location=Ballentine

|mile=154.3

|road={{jct|state=SC|SC|6|dir1=east|name1=Dreher Shoals Road|city1=Lexington}}}}

{{SCint|exit

|location=Irmo

|lspan=4

|type=concur

|mile=155.5

|road={{jct|state=SC|US|176|dir1=west|name1=Broad River Road|city1=Pomaria}}

|notes=West end of US 176 overlap}}

{{SCint|exit

|type=concur

|mile=158.3

|exit=101

|road={{jct|state=SC|I|26|US|176|dir1=west|dir2=east|name2=Broad River Road|city1=Spartanburg|city2=Columbia}}

|notes=West end of I-26 and east end of US 176 overlap
Signed as exits 101A (west) and 101B (east)}}

{{SCint|exit

|mile=159.1

|exit=102

|road={{jct|state=SC|SC|60|name1=Lake Murray Boulevard|city1=Irmo}}

|notes=Signed as exits 102A (west) and 102B (east)}}

{{SCint|exit

|mile=160.3

|exit=103

|road=Harbison Boulevard}}

{{SCint|exit

|county=Lexington

|cspan=2

|location=none

|mile=161.2

|exit=104

|road=Piney Grove Road}}

{{SCint|exit

|location=none

|mile=163.3

|exit=106

|road=St. Andrews Road}}

{{SCint|exit

|county=Richland

|cspan=23

|location=Columbia

|lspan=19

|mile=164.0

|exit=107

|road={{Jct|state=SC|I|20|location1=Augusta|city2=Florence}}

|notes=Signed as exits 107A (west) and 107B (east)}}

{{SCint|exit

|mile=164.5

|exit=108A

|road=Bush River Road}}

{{SCint|exit

|mile=164.8

|exit=108B

|type=concur

|road={{jct|state=SC|I|26|dir1=east|city1=Charleston|location2=Airport}}

|notes=East end of I-26 and west end of I-126 overlap}}

{{SCint|exit

|mile=165.6

|type=incomplete

|road=Colonial Life Boulevard to Bush River Road

|notes=Westbound exit and eastbound entrance}}

{{SCint|exit

|mile=166.7

|road=Greystone Boulevard – Riverbanks Zoo}}

{{SCint|exit

|mile=168.2

|type=concur

|road={{Jct|state=SC|US|21|US|176|US|321|dir1=south|dir2=east|dir3=south|name3=Huger Street}}

|notes=East end of I-126/US 176 and south end of US 21/US 321 overlap}}

{{SCint|exit

|mile=168.8

|road={{Jct|state=SC|SC|48|dir1=east|name1=Assembly Street}}}}

{{SCint|exit

|mile=168.9

|type=concur

|road={{Jct|state=SC|US|21|US|176|US|321|dir1=north|dir2=west|dir3=north|name3=Main Street|city1=Chester|city2=Rock Hill}}

|notes=US 176 and North end of US 21/US 321 and west end of US 176 overlap}}

{{SCint|exit

|mile=169.2

|road={{Jct|state=SC|SC|277|I|20|I|77|dir1=north|to2=to|name1=Bull Street}}}}

{{SCint|exit

|mile=169.7

|road={{Jct|state=SC|SC|12|name1=Taylors Street|city1=Lexington}}

|notes=To Fort Jackson}}

{{SCint|exit

|type=concur

|mile=170.1

|road={{Jct|state=SC|US|1|US|378|dir1=south|dir2=west|name2=Gervais Street}}

|notes=South end of US 1 and west end of US 378 overlap}}

{{SCint|exit

|type=concur

|mile=171.0

|road={{Jct|state=SC|US|1|dir1=north|name1=Millwood Avenue|city1=Camden}}

|notes=North end of US 1 overlap}}

{{SCint|exit

|mile=172.4

|road={{jct|state=SC|road|Devine Street|dir1=west|name1=US 21 Conn. west / US 76 Conn. west|to2=y|US|21|US|321|road|Millwood Avenue ends}}

|notes=Eastern terminus of US 21 Conn. and western segment of US 76 Conn., which use Devine Street

}}

{{SCint|exit

|mile=173.3

|road={{Jct|state=SC|SC|16|name1=Beltline Boulevard}}}}

{{SCint|exit

|mile=173.5

|road={{jct|state=SC|SC|760|dir1=east|name1=Fort Jackson Boulevard|road|Cross Hill Road|dir2=north|name2=US 76 Conn. west|location1=Fort Jackson}}

|notes=Eastern terminus of central segment of US 76 Conn.; western terminus of SC 760

}}

{{SCint|exit

|mile=

|road={{jct|state=SC|road|Rosewood Drive|dir1=west|road|Wildcat Road|dir2=east|name2=US 76 Conn.|location1=Midlands Technical College Beltline Campus|location2=Jim Hamilton–L.B. Owens Airport|location3=Fort Jackson|extra=airport}}

|notes=Eastern segment of US 76 Conn.

}}

{{SCint|exit

|mile=175.1

|road={{Jct|state=SC|SC|262|dir1=east|name1=Leesburg Road|city1=Leesburg}}}}

{{SCint|exit

|mile=175.3

|road={{Jct|state=SC|I|77|city1=Charleston|location2=Charlotte}}}}

{{SCint|exit

|mile=177.5

|road={{Jct|state=SC|SC|768|dir1=west|name1=Pineview Road}}}}

{{SCint|exit

|location=Horrell Hill

|mile=182.6

|road={{Jct|state=SC|SC|769|dir1=east|name1=Congaree Road|city1=Congaree}}}}

{{SCint|exit

|location=none

|mile=187.0

|road={{Jct|state=SC|SC|764|dir1=east|name1=Old Eastover Road|city1=Eastover}}}}

{{SCint|exit

|location=none

|mile=191.9

|road={{Jct|state=SC|US|601|name1=McCords Ferry Road|city1=St. Matthews|city2=Camden}}}}

{{SCint|exit

|location=none

|mile=194.2

|road={{Jct|state=SC|SC|263|dir1=south|name1=Vanboklen Road|city1=Eastover}}}}

{{SCint|exit

|county=Sumter

|cspan=9

|location=Stateburg

|mile=201.4

|road={{Jct|state=SC|SC|261|city1=Wedgefield|city2=Horatio|city3=Camden|city4=Manning}}}}

{{SCint|exit

|location=Sumter

|lspan=7

|mile=203.0

|road={{Jct|state=SC|SC|441|name1=Patriot Parkway|city1=Bishopville}}}}

{{SCint|exit

|mile=203.4

|road=Shaw Drive

|notes=To Shaw Air Force Base}}

{{SCint|exit

|mile=209.7

|road={{Jct|state=SC|SC|120|dir1=west|name1=Alice Drive|city1=Pinewood}}}}

{{SCint|exit

|mile=210.2

|road={{Jct|state=SC|US|521|US-Bus|76|dir2=east|dab2=Sumter|name2=Broad Street|city1=Sumter|city2=Camden}}}}

{{SCint|exit

|mile=212.4

|road={{Jct|state=SC|US|15|name1=Main Street|city1=Bishopville}}

|notes=Exit ramps connect via frontage roads}}

{{SCint|exit

|mile=214.0

|road={{Jct|state=SC|US|401|name1=Oswego Road|city1=Darlington}}

|notes=Exit ramps connect via frontage roads}}

{{SCint|exit

|type=concur

|mile=215.0

|road={{Jct|state=SC|US|378|US-Bus|76|dir1=east|dir2=west|dab2=Sumter|name2=Liberty Street|city1=Conway|city2=Sumter}}

|notes=East end of US 378 overlap}}

{{SCint|exit

|location=Mayesville

|mile=222.3

|road={{Jct|state=SC|SC|154|dir1=north|name1=Lafayette Street|city1=St. Charles}}}}

{{SCint|exit

|county=Lee

|cspan=2

|location=none

|mile=225.0

|road={{Jct|state=SC|SC|527|name1=Elliott Highway|city1=Elliott|city2=Kingstree}}}}

{{SCint|exit

|location=Lynchburg

|mile=231.9

|road={{Jct|state=SC|SC|341|name1=Lynchburg Highway|city1=Bishopville|city2=Lake City}}}}

{{SCint|exit

|county=Florence

|cspan=10

|location=none

|type=concur

|mile=239.6

|road={{Jct|state=SC|SC|403|dir1=south|name1=Cale Yarborough Highway|city1=Sardis}}

|notes=South end of SC 403 overlap}}

{{SCint|exit

|location=Timmonsville

|type=concur

|mile=241.1

|road={{Jct|state=SC|SC|403|dir1=north|name1=Brockington Street|city1=Hartsville}}

|notes=North end of SC 403 overlap}}

{{SCint|exit

|location=Florence

|lspan=6

|mile=245.2

|road={{Jct|state=SC|I|95|location1=Savannah|location2=Fayetteville}}}}

{{SCint|exit

|mile=249.2

|road={{Jct|state=SC|SC|51|dir1=south|name1=2nd Loop Road|city1=Pamplico}}}}

{{SCint|exit

|mile=249.5

|road={{jct|state=SC|road|David H. McLeod Boulevard|dir1=west|name1=US 76 Conn. west|to2=y|BS|20|dab2=Florence|I|20|I|95|dir4=north|city1=Columbia}}

|notes=Eastern terminus of US 76 Conn.

}}

{{SCint|exit

|mile=

|type=concur

|road={{jct|state=SC|road|South Coit Street|name1=US 52 Conn. north}}

|notes=Western end of US 52 Conn. concurrency

}}

{{SCint|exit

|mile=251.9

|type=concur

|road={{jct|extra=rail}}{{Jct|state=SC|US|52|name1=South Irby Street|to2=y|I|95|city1=Charleston|city2=Darlington|location3=Downtown|location4=County complex|location5=Judicial center|location6=McLeod Medical Center|location7=Carolina Hospital|extra=hospital}}

|notes=Eastern end of US 52 Conn. concurrency; southern terminus of US 52 Conn.

}}

{{SCint|exit

|mile=

|road={{jct|state=SC|US-Truck|52|dab1=Florence|name1=South Church Street}}

}}

{{SCint|exit

|location=none

|type=concur

|mile=256.7

|road={{Jct|state=SC|US|301|SC|327|dir1=south|dir2=north|name1=Freedom Boulevard|name2=Williston Road|to3=y|I|20|I|95}}

|notes=South end of US 301 and north end of SC 327 overlap}}

{{SCint|exit

|location=Mars Bluff

|type=concur

|mile=258.4

|road={{Jct|state=SC|SC|327|name1=Francis Marion Road|city1=Pamplico}}

|notes=South end of SC 327 overlap}}

{{SCint|exit

|county=Marion

|cspan=7

|location=Pee Dee

|type=concur

|mile=265.6

|road={{Jct|state=SC|US|301|dir1=north|city1=Dillon}}

|notes=North end of US 301 overlap; eastbound left exit and westbound entrance}}

{{SCint|exit

|location=West Marion

|mile=272.1

|road={{Jct|state=SC|SC|576|US|501|dir1=South|to2=to|city1=Conway|city2=Myrtle Beach|city3=North Myrtle Beach}}}}

{{SCint|exit

|location=Marion

|lspan=2

|mile=273.6

|road={{Jct|state=SC|US-Bus|501|SC-Alt|41|dab1=Marion|dab2=Marion|name2=Main Street|city1=Conway|city2=Dillon}}}}

{{SCint|exit

|mile=277.0

|road={{Jct|state=SC|US|501|city1=Conway|city2=Dillon}}

|notes=Interchange}}

{{SCint|exit

|location=none

|type=unbuilt

|road={{Jct|state=SC|I|73}}

|notes=Proposed interchange{{cite web |author = South Carolina Department of Transportation |author-link = South Carolina Department of Transportation |url = http://www.i73insc.com/southern_status.shtml |title = Project Status: Southern Project |work = I-73 Environmental Impact Study |publisher = South Carolina Department of Transportation |access-date = February 14, 2013 }}{{cite map |author = South Carolina Department of Transportation |url = http://www.i73insc.com/download/southernpage/marion.pdf |format = PDF |title = I-73 Southern Map |publisher = South Carolina Department of Transportation |inset = Marion |access-date = February 14, 2013 }}{{full citation needed|date= January 2017}}}}

{{SCint|exit

|location=Mullins

|mile=282.5

|road={{Jct|state=SC|SC|41|SC|917|name2=Main Street|city1=Loris|city2=Dillon}}}}

{{SCint|exit

|location=Nichols

|type=concur

|mile=289.7

|road={{Jct|state=SC|SC|9|dir1=north|name1=Main Street|city1=Lake View|city2=Dillon}}

|notes=North end of SC 9 overlap}}

{{SCint|exit

|county=Horry